WordNet

being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate
of or relating to or characteristic of or appropriate for children or young people; "juvenile diabetes"; "juvenile fashions"
a young person, not fully developed (同)juvenile person
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood

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1. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
2. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
3. 慢性骨髄単球性白血病 chronic myelomonocytic leukemia
4. 健常者および患者における胎児性ヘモグロビン（ヘモグロビンF） fetal hemoglobin hemoglobin f in health and disease
5. 神経線維腫症I型（NF1）：病因、臨床的特徴、および診断 neurofibromatosis type 1 nf1 pathogenesis clinical features and diagnosis

Juvenile myelomonocytic leukemia due to a germline CBL Y371C mutation: 35-year follow-up of a large family.

Pathak A1, Pemov A, McMaster ML, Dewan R, Ravichandran S, Pak E, Dutra A, Lee HJ, Vogt A, Zhang X, Yeager M, Anderson S, Kirby M; NCI DCEG Cancer Genomics Research Laboratory; NCI DCEG Cancer Sequencing Working Group, Caporaso N, Greene MH, Goldin LR, Stewart DR.
Human genetics.Hum Genet.2015 Jul;134(7):775-87. doi: 10.1007/s00439-015-1550-9. Epub 2015 May 5.
Juvenile myelomonocytic leukemia (JMML) is a pediatric myeloproliferative neoplasm that arises from malignant transformation of the stem cell compartment and results in increased production of myeloid cells. Somatic and germline variants in CBL (Casitas B-lineage lymphoma proto-oncogene) have been a
PMID 25939664

Deficiency of beta common receptor moderately attenuates the progression of myeloproliferative neoplasm in Nras G12D/+ mice.

Zhang J1, Ranheim EA1, Du J1, Liu Y1, Wang J1, Kong G1, Zhang J2.
The Journal of biological chemistry.J Biol Chem.2015 Jun 16. pii: jbc.M115.653154. [Epub ahead of print]
Activating Ras signaling is a major driver in juvenile and the myeloproliferative variant of chronic myelomonocytic leukemia (JMML/MP-CMML). Numerous studies suggest that GM-CSF signaling plays a central role in establishing and maintaining JMML/MP-CMML phenotypes in human and mouse. However, it rem
PMID 26082490

Flow cytometry as a diagnostic support tool in juvenile myelomonocytic leukemia.

Maioli MC1, Fernandez TS, Campos MM, Diamond HR, Veranio-Silva GA, de Souza AM, da Costa ES, Ornellas MH, Thiago LS.
Leukemia & lymphoma.Leuk Lymphoma.2015 Jun 16:1-4. [Epub ahead of print]
PMID 25956043

立石八寿貴,安田秀美,宇加江進,小田孝憲
日本皮膚科学会雑誌 115(8), 1181-1187, 2005
症例は8カ月女児．18トリソミー，若年型慢性骨髄性白血病で経過観察中に頭部，顔面，頸部に爪甲大までの黄色丘疹，結節が多発し，徐々に数，大きさとも増加した．血清脂質は正常でカフェオレ斑を認めた．病理組織学的には真皮から皮下組織にかけてS100陰性，CD68陽性の泡沫細胞の浸潤を認め，若年性黄色肉芽腫と診断した．呼吸不全のため1歳5カ月で永眠した．剖検で肝臓にも泡沫状の細胞質を有する細胞を多数認めた． …
NAID 130004708390

増井紗矢香,黒田浩之,堀啓一郎
日本鼻科学会会誌 44(4), 297-301, 2005
… Histological examination led to a diagnosis of juvenile xanthogranuloma. … Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis. … It is not associated with metabolic abnormalities, hyperlipemia or diabetes but sometimes presents in association with neurofibromatosis and juvenile chronic myelogenous leukemia. …
NAID 130003873806