WordNet

a complex consisting of an organic base in association with hydrogen chloride

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 男性性機能不全の治療 treatment of male sexual dysfunction

English Journal

Effect of xylazine, isoxsuprine, and lidocaine on Doppler sonographic uterine and umbilical blood flow measurements in cows during the last month of pregnancy.

Waldvogel D1, Bleul U2.Author information 1Unit of Large Animal Reproduction, Clinic for Reproductive Medicine, University of Zurich, Zurich, Switzerland.2Unit of Large Animal Reproduction, Clinic for Reproductive Medicine, University of Zurich, Zurich, Switzerland. Electronic address: ubleul@vetclinics.uzh.ch.AbstractThe maternal portion of the bovine placenta receives blood mainly from the uterine arteries (AUT) and the fetal portion from the umbilical arteries (AUM). Placental perfusion is crucial for fetal development and undergoes adaptive changes during pregnancy according to the fetal requirements. One goal of this study was to investigate changes in Doppler sonographic measurements of blood vessels that supply blood to the placenta in cows during the last 4 weeks of pregnancy. Another goal was to examine how these measurements are affected by three drugs commonly used in cows at the time of parturition. Nine cows underwent Doppler sonographic examination of the AUT ipsilateral and contralateral to the pregnant horn and one AUM three times per week during the last 4 weeks of gestation. This was followed by the randomized administration of one of the three following experimental drugs per day: isoxsuprine (200 mg/cow, iv), xylazine (2 mg/100 kg, iv), and lidocaine for epidural anesthesia (100 mg/cow). Doppler sonographic examination was repeated 30 minutes after medication. Maternal pulse rate increased during the study period (P < 0.001), and the diameter of the contralateral AUT was smaller in the last week before birth than in the two preceding weeks. The resistance index (RI) of the ipsilateral AUT was smaller in the last week than in the first 2 weeks of the study period. Uterine blood flow volume increased after isoxsuprine by 5% and after epidural anesthesia by 6% (both P ≤ 0.05) and decreased after xylazine by 10% (P < 0.001). Isoxsuprine was the only drug that elevated the blood flow volume in the AUM (P ≤ 0.05). Xylazine increased the RI of both AUT (both P < 0.001) and significantly reduced maternal and fetal pulse frequencies, whereas isoxsuprine significantly reduced the RI of both AUT and the AUM and increased maternal and fetal pulse frequencies. The results reported that Doppler sonographic measurements of uterine and AUM change little in the last month of pregnancy in the cow. Isoxsuprine and epidural anesthesia with lidocaine have the potential to improve uterine perfusion.
Theriogenology.Theriogenology.2014 Apr 15;81(7):993-1003. doi: 10.1016/j.theriogenology.2014.01.031. Epub 2014 Jan 31.
The maternal portion of the bovine placenta receives blood mainly from the uterine arteries (AUT) and the fetal portion from the umbilical arteries (AUM). Placental perfusion is crucial for fetal development and undergoes adaptive changes during pregnancy according to the fetal requirements. One goa
PMID 24581585

Relaxant effect of proton pump inhibitors on in vitro myometrium from pregnant women.

Terranova C1, Petrella C2, Improta G3, Severini C4, Signore F5, Damiani P5, Plotti F1, Scarpignato C6, Angioli R1.Author information 1Department of Obstetrics and Gynaecology, "Campus Bio Medico" University, Rome, Italy.2Department of Physiology and Pharmacology "V. Erspamer", Sapienza University, Rome, Italy. Electronic address: carla.petrella@uniroma1.it.3Department of Physiology and Pharmacology "V. Erspamer", Sapienza University, Rome, Italy.4Institute of Cellular Biology and Neurobiology, CNR, Rome, Italy.5Department of Obstetrics and Gynaecology, San Camillo - Forlanini Hospital, Rome, Italy.6Division of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy.AbstractAIM: In this study we investigate in in vitro myometrial tissue samples of pregnant women: (a) the effects of proton pomp inhibitors (PPIs) (omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole) on spontaneous contractions; (b) the muscle-relaxant efficacy of the most active PPI considered (pantoprazole) in comparison with that of other known tocolytics (nifedipine, atosiban, MgSO4, isoxsuprine); (c) the effect of pantoprazole on contractions induced by calcium (Ca(++)), KCl, oxytocin and prostaglandin (PGE2); (d) the possible mediators of pantoprazole relaxant effect.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Feb 14;52:125-31. doi: 10.1016/j.ejps.2013.10.007. Epub 2013 Nov 9.
AIM: In this study we investigate in in vitro myometrial tissue samples of pregnant women: (a) the effects of proton pomp inhibitors (PPIs) (omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole) on spontaneous contractions; (b) the muscle-relaxant efficacy of the most active PPI cons
PMID 24215738

Vasodilator isoxsuprine alleviates symptoms of oral submucous fibrosis.

Bhadage CJ1, Umarji HR, Shah K, Välimaa H.Author information 1Department of Oral Medicine & Radiology, MGV's KBH Dental College & Hospital, Nashik, Maharashtra, India. drchetanb@yahoo.co.inAbstractOBJECTIVES: The aim of the study was to compare the effectiveness of vasodilator isoxsuprine to dexamethasone with hyaluronidase injections and physiotherapy in the treatment of oral submucous fibrosis.
Clinical oral investigations.Clin Oral Investig.2013 Jun;17(5):1375-82. doi: 10.1007/s00784-012-0824-z. Epub 2012 Aug 15.
OBJECTIVES: The aim of the study was to compare the effectiveness of vasodilator isoxsuprine to dexamethasone with hyaluronidase injections and physiotherapy in the treatment of oral submucous fibrosis.MATERIALS AND METHODS: Forty patients with oral submucous fibrosis were randomly assigned into thr
PMID 22893038