Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/18 04:22:31」(JST)

wiki en

Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator^[2] in humans (under the trade name Duvadilan) and equines. Isoxsuprine is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle via beta-2 receptors.^[3]

Use in equines[edit]

Reasons for use and controversy[edit]

Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis and navicular disease, as its effects as a vasodilator are thought to increase circulation within the hoof to help counteract the problems associated with these conditions.

There are many veterinarians—and horsemen—who do not believe isoxsuprine to be effective. Its use is therefore rather controversial within the veterinary field.

Precautions and side-effects[edit]

Isoxsuprine may increase the animal's heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs. Because it is a vasodilator, it should not be used in horses that are bleeding, or in mares following foaling.

Isoxsuprine is a prohibited class B drug in FEI-regulated competition, and is often prohibited by other equine associations. It may be detected in the urine for several weeks or months following administration. It is therefore important to check the drug-rules within an animal's given competitive organization, before administering the drug.

Administration[edit]

Isoxsuprine is given orally, and many horses find the pills quite palatable.

Use in humans[edit]

Isoxsuprine it is used in humans for treatment of premature labour, i.e. a tocolytic,^[4] and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions.^[5]

References[edit]

^ Isoxsuprine - Compound Summary, PubChem.
^ Gozo EG, Yebes RB (November 1984). "Hemodynamic effects of isoxsuprine in cardiac failure". Chest 86 (5): 736–40. doi:10.1378/chest.86.5.736. PMID 6488912. Cite uses deprecated parameters (help)
^ Falkay, G.; Kovács, L. (1986). "Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors". Journal of perinatal medicine 14 (2): 109–113. PMID 2874205. edit
^ Giorgino, F. L.; Egan, C. G. (2010). "Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: A systematic review of previous literature". Arzneimittel-Forschung 60 (7): 415–420. doi:10.1055/s-0031-1296305. PMID 20712130. edit
^ Drugs.com: Isoxsuprine

Forney, Barbara C, MS, VMD. Equine Medications, Revised Edition. Blood Horse Publications. Lexington, KY. Copyright 2007.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 男性性機能不全の治療 treatment of male sexual dysfunction

English Journal

Spectrofluorimetric determination of certain adrenergic agonist drugs in their pure forms and pharmaceutical formulations: Content uniformity test application.

Badr El-Din KM1, Attia TZ1.
Luminescence : the journal of biological and chemical luminescence.Luminescence.2016 Nov 29. doi: 10.1002/bio.3240. [Epub ahead of print]
A new, simple, sensitive and rapid spectrofluorimetric method has been developed for determination of certain adrenergic agonists such as isoxsuprine hydrochloride, ritodrine hydrochloride and etilefrine hydrochloride in their pure forms and pharmaceutical dosage forms. The method depends on micella
PMID 27900836

Bovine teeth as a novel matrix for the control of the food chain: liquid chromatography-tandem mass spectrometry detection of treatments with prednisolone, dexamethasone, estradiol, nandrolone and seven β2-agonists.

Chiesa LM1, Nobile M1, Panseri S1, Biolatti B2, Cannizzo FT2, Pavlovic R1, Arioli F1.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2016 Nov 15:1-9. [Epub ahead of print]
Veterinary drugs usually have rapid clearance rates in the liver and kidney, hampering their detection in conventional matrices such as the liver or urine. Pharmacological principles such as esterification may be applied to facilitate the administration of veterinary drugs and increase drug half-lif
PMID 27845609

Effects of isoxsuprine hydrochloride on electrocardiographic and trace element status in sheeps.

Vural HA1, Koenhemsi L2, Gonul R3, Yardibi HD4, Gulyasar T5, Or E3, Hosturk GT6, Barutcu B7, Balci H8.
JPMA. The Journal of the Pakistan Medical Association.J Pak Med Assoc.2016 Aug;66(8):938-42.
OBJECTIVE: To study the effect of isoxsuprine hydrochloride on the ischaemic electrocardiographic change and trace element status in sheep.METHODS: This study was conducted from March 16 to 23, 2012, at Istanbul University, Turkey, and comprised sheep aged 6 months. The animals were divided into two
PMID 27524523

Japanese Journal

Two Cases of Delayed Interval Delivery of the Second Twin

Somekawa Yoshiaki,Ohmoto Kazumi,Sato Daigo,Sakakibara Sayako,Umeki Hidenori
Journal of Rural Medicine 2(2), 132-136, 2007
… At 26 weeks, due to adverse effects, ritodrine was changed to isoxsuprine and magnesium sulfate to control uterine contractions. … At 33 weeks and 5 days, onset of labor was observed, and 11 hours after the cessation of treatment with isoxsuprine and magnesium sulfate, a viable female fetus was delivered by spontaneous vaginal delivery, weighing 1,806 g. …
NAID 130004725923

11-17.Comparison of efficacy between oral nimesulide and parenteral-oral isoxsuprine to delay threatened preterm labor (Session 12 Perinatology 1)

Purwaka B. T.,Abadi A.,Prasetyadi F. O. H.
日本産科婦人科學會雜誌 56(2), 461, 2004-02-01
NAID 110002101373

リトドリンおよびイソクスプリン投与牛における子宮運動抑制

大浪洋二,佐々木佳子,松浦由美 [他],森純一
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 50(7), 390-393, 1997-07-20
NAID 10018950508

Related Pictures

★リンクテーブル★

リンク元	「切迫早産」「イソクスプリン」
拡張検索	「isoxsuprine hydrochloride」

「切迫早産」

Isoxsuprine
	IUPAC name 4-{1-hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl}phenol
	Other names Vasodilian, Duvadilan
Identifiers
CAS number	395-28-8
PubChem	3783
ChemSpider	3651
KEGG	D08092
MeSH	Isoxsuprine
ChEMBL	CHEMBL1197051
ATC code	C04AA01
Jmol-3D images	Image 1
	SMILES O(c1ccccc1)CC(NC(C)C(O)c2ccc(O)cc2)C ;
	InChI InChI=1S/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3 ; Key: BMUKKTUHUDJSNZ-UHFFFAOYSA-N InChI=1/C18H23NO3/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3; Key: BMUKKTUHUDJSNZ-UHFFFAOYAW ;
Properties
Molecular formula	C18H23NO3
Molar mass	301.38 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C or 77 °F, 100 kPa)
	Infobox references