1. a widely used inhalation anesthetic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/05 09:36:42」(JST)

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English Journal

  • PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats.
  • Manaenko A, Sun X, Kim CH, Yan J, Ma Q, Zhang JH.SourceDepartment of Basic Sciences, Loma Linda University, Loma Linda, California, USA. Electronic address:
  • Neurobiology of disease.Neurobiol Dis.2013 Feb;50C:13-20. doi: 10.1016/j.nbd.2012.09.004. Epub 2012 Sep 19.
  • Neurosurgical procedures inevitably produce intraoperative hemorrhage. The subsequent entry of blood into the brain parenchyma results in the release of large amounts of thrombin, a known contributor to perihematomal edema formation and apoptosis after brain injury. The present study seeks to test 1
  • PMID 23000356
  • Effects of an opioid on respiratory movements and expiratory activity in humans during isoflurane anaesthesia.
  • Drummond GB, Dhonneur G, Kirov K, Duvaldestin P.SourceDépartement d'Anésthesie et Réanimation, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France. Electronic address:
  • Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2013 Jan 15;185(2):425-34. doi: 10.1016/j.resp.2012.08.016. Epub 2012 Aug 25.
  • Opioids increase abdominal muscle activity during anaesthesia. We proposed that opioid activity during anaesthesia would change chest wall size and movement, and contribute to ventilation. Using an optical system to measure chest wall volume, we studied 10 patients during isoflurane anaesthesia, fir
  • PMID 22944354
  • Adenosine A2 receptor-mediated regulation of renal hemodynamics and glomerular filtration rate is abolished in diabetes.
  • Persson P, Hansell P, Palm F.SourceDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
  • Advances in experimental medicine and biology.Adv Exp Med Biol.2013;765:225-30. doi: 10.1007/978-1-4614-4989-8_31.
  • Alterations in glomerular filtration rate (GFR) are one of the earliest indications of altered kidney function in diabetes. Adenosine regulates GFR through tubuloglomerular feedback mechanism acting on adenosine A1 receptor. In addition, adenosine can directly regulate vascular tone by acting on A1
  • PMID 22879037

Japanese Journal

  • Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice
  • Shintaku Tomohiro,Ohba Takayoshi,Niwa Hidetoshi,Kushikata Tetsuya,Hirota Kazuyoshi,Ono Kyoichi,Matsuzaki Yasushi,Imaizumi Tadaatsu,Sawamura Daisuke,Murakami Manabu
  • 弘前医学 66(1), 15-21, 2015-04-06
  • … We compared the effects of inhalation anesthesia( 2% isoflurane), intraperitoneal injection of pentobarbital anesthesia (50 mg/kg), and a combination anesthetic consisting of medetomidine, midazolam and butorphanol (MMB) on electrocardiograms in mice. … Using either isoflurane inhalation anesthesia or pentobarbital anesthesia, heart rate (HR) was in the acceptable range (ca. …
  • NAID 120005606071
  • Effects of Isoflurane Inhalation Anesthesia on Mouse ECG
  • Shintaku Tomohiro,Ohba Takayoshi,Niwa Hidetoshi,Kushikata Tetsuya,Hirota Kazuyoshi,Ono Kyoichi,Matsuzaki Yasushi,Imaizumi Tadaatsu,Sawamura Daisuke,Murakami Manabu
  • 弘前医学 66(1), 1-7, 2015-04-06
  • General anesthesia is important for pharmacological studies in laboratory animals. Although a number of transgenic animals have been reported, basic analyses concerning mouse ECG and heart rate variab …
  • NAID 120005606069
  • Shintaku Tomohiro,Ohba Takayoshi,Niwa Hidetoshi [他]
  • 弘前医学 66(1), 15-21, 2015
  • NAID 40020432735

Related Links

イソフルラン(英:isoflurane)とは吸入麻酔薬のひとつ。常温では不燃性の液体であり、 エンフルランの構造異性体である。CAS登録番号は [26675-46-7]。中枢神経の抑制、 呼吸抑制、血圧低下、筋弛緩などの薬理作用があるが、痙攣作用は持たない。長時間 ...
Isoflurane (2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane) is a halogenated ether used for inhalational anesthesia. Together with enflurane and halothane, it replaced the flammable ethers used in the pioneer days of surgery. Its name ...

Related Pictures

Isoflurane USPIsoflurane2.pngAgent fill tube for Isoflurane.Attane™ IsofluraneBuy Isoflurane SyrupsDescription Isoflurane-3D-balls.png




  • セボフルランよりMACが低い。
  • 軽度の刺激性があるために、セボフルランがよい例がある。
  • 悪性高熱症は少ないが起こりうる。
  • 肝臓でわずかに代謝を受ける(0.2%)。