イソクエン酸

関: isocitric acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/17 21:59:41」(JST)

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Isocitric acid is a protonated form of isocitrate, which is a substrate of the citric acid cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase. Salts and esters of isocitric acid are known as isocitrates.

Isocitric acid is commonly used as a marker to detect the authenticity and quality of fruit products, most often citrus juices. In authentic orange juice, for example, the ratio of citric acid to D-isocitric acid is usually less than 130. An isocitric acid value higher than this may be indicative of fruit juice adulteration.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=TCA Cycle edit]]

File:TCACycle WP78.png

TCA Cycle edit

^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

References

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UpToDate Contents

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1. 悪性神経膠腫の病因と分子生物学 pathology and molecular pathogenesis of diffuse gliomas
2. 肝細胞障害を検出するための肝臓生化学検査 liver biochemical tests that detect injury to hepatocytes
3. 乏突起膠腫の臨床的特徴、病理、および予後因子 clinical features pathology and prognostic factors for oligodendroglial tumors
4. 低悪性度神経膠腫のマネージメント management of low grade glioma
5. 軟骨肉腫 chondrosarcoma

English Journal

Effects of granulation on organic acid metabolism and its relation to mineral elements in Citrus grandis juice sacs.

Wang XY, Wang P, Qi YP, Zhou CP, Yang LT, Liao XY, Wang LQ, Zhu DH, Chen LS.SourceInstitute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Food chemistry.Food Chem.2014 Feb 15;145:984-90. doi: 10.1016/j.foodchem.2013.09.021. Epub 2013 Sep 11.
We investigated the effects of granulation on organic acid metabolism and its relation to mineral elements in 'Guanximiyou' pummelo (Citrus grandis) juice sacs. Granulated juice sacs had decreased concentrations of citrate and isocitrate, thus lowering juice sac acidity. By contrast, malate concentr
PMID 24128573

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death.

Mohrenz IV, Antonietti P, Pusch S, Capper D, Balss J, Voigt S, Weissert S, Mukrowsky A, Frank J, Senft C, Seifert V, von Deimling A, Kögel D.SourceExperimental Neurosurgery, Neuroscience Center, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Apoptosis : an international journal on programmed cell death.Apoptosis.2013 Nov;18(11):1416-25. doi: 10.1007/s10495-013-0877-8.
Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to α-ketoglutarate (α-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger. Mutation of R132 of IDH1 abrogates generation of α-KG and leads to conversion of α-KG
PMID 23801081

Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.

Macdonald MJ, Brown LJ, Longacre MJ, Stoker SW, Kendrick MA.SourceChildrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA. Electronic address: mjmacdon@wisc.edu.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1830(11):5104-11. doi: 10.1016/j.bbagen.2013.07.013. Epub 2013 Jul 20.
BACKGROUND: There are three isocitrate dehydrogenases (IDHs) in the pancreatic insulin cell; IDH1 (cytosolic) and IDH2 (mitochondrial) use NADP(H). IDH3 is mitochondrial, uses NAD(H) and was believed to be the IDH that supports the citric acid cycle.METHODS: With shRNAs targeting mRNAs for these enz
PMID 23876293

Japanese Journal

グリオーマの遺伝子異常に基づいた化学療法の最新知見

夏目敦至,Lushun Chalise,若林俊彦
脳神経外科ジャーナル 24(6), 386-398, 2015
… グリオーマ (神経膠腫) の化学療法を理解するために必要な遺伝子変化として, O6-methylguanine DNA-methyltransferase (MGMT), 染色体1p19q, epidermal growth factor receptor (EGFR), TP53, およびisocitrate dehyrodogenase (IDH) 1 & IDH 2等が特に着目されている. …
NAID 130005083637

Pathology and Genetics of Diffuse Gliomas in Adults

KOMORI Takashi
Neurologia medico-chirurgica 55(1), 28-37, 2015
… Recent genetic studies have revealed that the major categories of gliomas, such as circumscribe astrocytomas, infiltrating astrocytomas/oligodendrogliomas, and glioblastoma, roughly correspond to major genetic alterations, including isocitrate dehydrogenases (IDHs) 1/2 mutations, TP53 mutations, co-deletion of chromosome arms 1p/19q, and BRAF mutation/fusion. …
NAID 130004922265

エピゲノム解析による造血器腫瘍の発症・進展機序の解明 (特集ゲノム解析が明らかにした新しい血液疾患の病態と分類)

松井啓隆
血液内科 69(6), 707-712, 2014-12
NAID 40020310576

「isocitric acid」

Isocitric acid
Names
	IUPAC name 1-Hydroxypropane-1,2,3-tricarboxylic acid
Identifiers
CAS Registry Number	320-77-4
ChEBI	CHEBI:30887
ChEMBL	ChEMBL539669
ChemSpider	1161
DrugBank	DB01727 °
	InChI InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) ; Key: ODBLHEXUDAPZAU-UHFFFAOYSA-N ; InChI=1/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13); Key: ODBLHEXUDAPZAU-UHFFFAOYAX ;
Jmol-3D images	Image
KEGG	C00311
MeSH	Isocitrate
PubChem	1198
	SMILES O=C(O)C(CC(=O)O)C(O)C(=O)O ;
Properties
Chemical formula	C6H8O7
Molar mass	192.124
Melting point	105 °C (221 °F; 378 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

　　[★]

イソクエン酸

関: isocitrate

「イソクエン酸」

　　[★]

英: isocitrate
関: クエン酸

「isocitrate dehydrogenase kinase」

　　[★] イソクエン酸デヒドロゲナーゼキナーゼ

「isocitrate dehydrogenase」

　　[★] イソクエン酸デヒドロゲナーゼ

「isocitrate lyase」

　　[★]

イソクエン酸リアーゼ

[WikiPathways-1] The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

リンク元	「isocitric acid」「イソクエン酸」
拡張検索	「isocitrate dehydrogenase kinase」「isocitrate dehydrogenase」「isocitrate lyase」

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案内

案内

isocitrate