関: Omnipaque

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/16 16:04:41」(JST)

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Iohexol is a contrast agent, sold under the trade name Omnipaque. It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.^[1] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.^[2]

References [edit]

^ GE Healthcare (May 2006). "Omnipaque (Iohexol) injection. Product label". DailyMed. U.S. National Library of Medicine. Retrieved 2007-03-28.
^ Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S. National Library of Medicine. Retrieved 2007-03-29.

External links [edit]

Omnipaque (Iohexol) injection, solution

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1. 血管内腹部大動脈修復術の合併症 complications of endovascular abdominal aortic repair
2. 造影剤に対する即時型過敏反応：臨床症状、診断、および治療 immediate hypersensitivity reactions to radiocontrast media clinical manifestations diagnosis and treatment
3. 腎機能の評価 assessment of kidney function
4. 造影剤誘発性腎症の予防 prevention of contrast induced nephropathy
5. 造影剤誘発性腎症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of contrast induced nephropathy

English Journal

Diagnostic evaluation of patients with nonimmediate cutaneous hypersensitivity reactions to iodinated contrast media.

Torres MJ, Gomez F, Doña I, Rosado A, Mayorga C, Garcia I, Blanca-Lopez N, Canto G, Blanca M.SourceAllergy Service, Carlos Haya Hospital, Malaga, Spain.
Allergy.Allergy.2012 Jul;67(7):929-35. doi: 10.1111/j.1398-9995.2012.02840.x. Epub 2012 May 15.
BACKGROUND: Nonimmediate hypersensitivity reactions to iodinated contrast media (CM) are common. Allergological evaluation is necessary to confirm the diagnosis and to find a tolerated alternative. The aim of this study was to establish the role of skin testing and the drug provocation test (DPT) in
PMID 22583135

Comparison of iodixanol 320 and iohexol 350 in image quality during 64-slice multidetector computed tomography: Prospective randomized study.

Choi TY, Woo V, Gupta M, Sourayanezhad S, Li D, Mao SS, Budoff M.SourceKwandong University School of Medicine, Myongji Hospital, Department of Cardiology, Goyang-Si, Republic of Korea.
International journal of cardiology.Int J Cardiol.2012 Jun 28;158(1):134-8. Epub 2012 May 5.
PMID 22560910

Japanese Journal

The Assessments of Factors that Affect Glomerular Filtration Rate and Indirect Markers of Renal Function in Dogs and Cats

MIYAGAWA Yuichi,TAKEMURA Naoyuki,HIROSE Hisashi
Journal of Veterinary Medical Science advpub(0), 1004030206, 2010
… The present study is a retrospective survey designed to assess the factors that affect markers of kidney function and to revaluate the clinically utility of these markers including P-UN, P-Cre, and GFR determined by plasma iohexol clearance (PCio) in dogs and cats. …
NAID 130000264234

The Evaluation of a Single Sampling Method for Estimation of Plasma Iohexol Clearance in Dogs and Cats with Various Kidney Functions

MIYAGAWA Yuichi,TAKEMURA Naoyuki,HIROSE Hisashi
Journal of Veterinary Medical Science advpub(0), 0911250053, 2010
… Plasma iohexol clearance (PCio) is a practical method for measuring the glomerular filtration rate (GFR) in clinical settings. … Plasma iohexol concentration was determined by a cerium arsenite colorimetric method. …
NAID 130000134537

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★リンクテーブル★

リンク元	「イオヘキソール」「Omnipaque」

「イオヘキソール」

Iohexol
Systematic (IUPAC) name
	1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	B (US)
Legal status	℞ Prescription only
Routes	Intrathecal, intravascular, oral, intracavital
Pharmacokinetic data
Protein binding	Low
Metabolism	Nil
Half-life	Variable
Excretion	Renal, unchanged
Identifiers
CAS number	66108-95-0
ATC code	V08AB02
PubChem	CID 3730
DrugBank	DB01362
ChemSpider	3599
UNII	4419T9MX03
KEGG	D01817
ChEBI	CHEBI:31709
ChEMBL	CHEMBL1200455
Chemical data
Formula	C19H26I3N3O9
Mol. mass	821.138 g/mol
	SMILES O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C;
	InChI InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) ; Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N ;
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