WordNet

in an interesting manner; "when he ceases to be just interestingly neurotic and...gets locked up"- Time
capable of arousing interest or curiosity; "our team came up with some most intriguing finds"

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1. 赤血球表面抗原および細胞骨格蛋白質の異常によるマラリアに対する防御 protection against malaria by abnormalities in red cell surface antigens and cytoskeletal proteins
2. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
3. 異常ヘモグロビン症におけるマラリアに対する防御 protection against malaria in the hemoglobinopathies
4. 脊髄小脳変性症 the spinocerebellar ataxias
5. 分子標的薬である血管新生阻害剤の毒性：心血管系以外への影響 toxicity of molecularly targeted antiangiogenic agents non cardiovascular effects

Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells.

Wang Z1, Cheng Q2, Tang K3, Sun Y1, Zhang K4, Zhang Y3, Luo S1, Zhang H3, Ye D2, Huang B5.
Cancer letters.Cancer Lett.2015 Aug 10;364(2):118-24. doi: 10.1016/j.canlet.2015.04.030. Epub 2015 May 12.
Lipoxin A4 (LXA4), an arachidonic acid-derived anti-inflammatory lipid mediator, shows anti-tumor potential by regulating tumor immune microenvironments. However, the underlying molecular and cellular basis of this function remains unclear. IL-10-producing B (Breg) cells display tumor-promoting effe
PMID 25979229

Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis.

Lau ST1, Zhou T1, Liu JA1, Fung EY2, Che CM2, Lang BH1, Ngan ES3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1852(8):1676-86. doi: 10.1016/j.bbadis.2015.05.005. Epub 2015 May 13.
A germline mutation (A339V) in thyroid transcription factor-1 (TITF1/NKX2.1) was shown to be associated with multinodular goiter (MNG) and papillary thyroid carcinoma (PTC) pathogenesis. The overexpression of A339V TTF1 significantly promoted hormone-independent growth of the normal thyroid cells, r
PMID 25981745

New insights into redox regulation of stem cell self-renewal and differentiation.

Ren F1, Wang K2, Zhang T3, Jiang J2, Nice EC4, Huang C5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1850(8):1518-1526. doi: 10.1016/j.bbagen.2015.02.017. Epub 2015 Mar 10.
BACKGROUND: Reactive oxygen species (ROS), the natural byproducts of aerobic metabolism, are precisely orchestrated to evoke diverse signaling pathways. To date, studies have focused mainly on the detrimental effects of ROS in stem cells. Recently, accumulating evidence has suggested that ROS also f
PMID 25766871

Yaguchi Shunsuke,Yamazaki Atsuko,Wada Wakana,Tsuchiya Yasutaka,Sato Toshihiko,Shinagawa Hideo,Yamada Yutaro,Yaguchi Junko
Development, growth & differentiation 57(3), 242-250, 2015-04
… Moreover, the males and females are easily distinguishable, and the style of early cleavages is intriguingly unusual, suggesting that this sea urchin might be a good candidate for addressing not only neurology but also cell and developmental biology. …
NAID 120005611477

Impact of Either GLP-1 Agonists or DPP-4 Inhibitors on Pathophysiology of Heart Failure

Takahashi Ayako,Ihara Madoka,Yamazaki Satoru,Asanuma Hiroshi,Asakura Masanori,Kitakaze Masafumi
International Heart Journal advpub(0), 2015
… Intriguingly, either DPP-IV inhibitors or GLP-1 analogues mediate cardioprotection even without IGT, suggesting two possible explanations: One is that GLP-1 analogues directly activate the prosurvival kinases, such as Akt and Erk1/2, and another is that DPP-IV inhibition increases cardioprotective peptides such as BNP and SDF-1α. …
NAID 130005084043

Suda Kentaro,Fukuoka Hidenori,Iguchi Genzo,Hirota Yushi,Nishizawa Hitoshi,Bando Hironori,Matsumoto Ryusaku,Takahashi Michiko,Sakaguchi Kazuhiko,Takahashi Yutaka
Endocrine Journal 62(1), 53-59, 2015
… Intriguingly, both these patients exhibited severe macroangiopathy and an absence of microangiopathy. …
NAID 130004770468