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any malignant tumor derived from epithelial tissue; one of the four major types of cancer

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1. 高リスクの子宮体癌に対する補助化学療法 adjuvant treatment of high risk endometrial cancers
2. 早期胃癌：疫学、臨床症状、診断、および病期分類 early gastric cancer epidemiology clinical manifestations diagnosis and staging
3. 大腸癌長期生存患者へのアプローチ approach to the long term survivor of colorectal cancer
4. 子宮体癌の補助化学療法の考え方 approach to adjuvant treatment of endometrial cancer
5. 子宮体癌：臨床的特徴および診断 endometrial carcinoma clinical features and diagnosis

English Journal

One-step circumferential endoscopic mucosal cap resection of Barrett's esophagus with early neoplasia.

Conio M1, Fisher DA2, Blanchi S3, Ruggeri C4, Filiberti R5, Siersema PD6.Author information 1Department of Gastroenterology, General Hospital, Sanremo, Italy. Electronic address: mxconio@tin.it.2Department of Gastroenterology, Durham Veterans Affairs Medical Center and Duke Medical Center, NC, USA.3Department of Gastroenterology, General Hospital, Sanremo, Italy.4Department of Pathology, General Hospital, Sanremo, Italy.5Epidemiology, Biostatistics and Clinical Trials, IRCCS, San Martino - IST National Institute for Cancer Research, Genova, Italy.6Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands.AbstractBACKGROUND AND OBJECTIVE: Focal endoscopic mucosal resection (EMR) of visible intraepithelial lesions arising within Barrett's esophagus (BE) may miss synchronous lesions that are not endoscopically apparent. Stepwise radical endoscopic resection would obviate this concern by removing all BE; however, it requires repeated endoscopy which may increase the risk of complications, particularly for patients with circumferential BE. The aim of the study was to evaluate the safety and efficacy of one-step complete circumferential resection of BE by cap-assisted EMR (EMR-C) among patients with circumferential BE and high-grade dysplasia or intramucosal carcinoma.
Clinics and research in hepatology and gastroenterology.Clin Res Hepatol Gastroenterol.2014 Feb;38(1):81-91. doi: 10.1016/j.clinre.2013.05.015. Epub 2013 Jul 12.
BACKGROUND AND OBJECTIVE: Focal endoscopic mucosal resection (EMR) of visible intraepithelial lesions arising within Barrett's esophagus (BE) may miss synchronous lesions that are not endoscopically apparent. Stepwise radical endoscopic resection would obviate this concern by removing all BE; howeve
PMID 23856637

Management controversies in Barrett's oesophagus.

Max Almond L1, Barr H.Author information 1Department of Upper GI Surgery, Leadon House, Gloucestershire Royal Hospital, Great Western Road, Gloucester, Gloucestershire, GL1 3NN, UK, mxa891@hotmail.com.AbstractThe management of Barrett's oesophagus and associated neoplasia has evolved considerably in recent years. Modern endoscopic strategies including endoscopic resection and mucosal ablation can eradicate dysplastic Barrett's and prevent progression to invasive oesophageal cancer. However, several aspects of Barrett's management remain controversial including the stage in the disease process at which to intervene, and the choice of endoscopic or surgical therapy. A review of articles pertaining to the management of Barrett's oesophagus with or without associated neoplasia, was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Embase and Cochrane databases were searched to identify literature relevant to eight pre-defined areas of clinical controversy. The following search terms were used: Barrett's oesophagus; dysplasia; intramucosal carcinoma; endotherapy; endoscopic resection; ablation; oesophagectomy. A significant body of evidence exists to support early endoscopic therapy for high-grade dysplasia (HGD). Although not supported by randomised controlled trial evidence, endoscopic therapy is now favoured ahead of oesophagectomy for most patients with HGD. Focal intramucosal (T1a) carcinomas can be managed effectively using endoscopic and surgical therapy, however surgery should be considered the first line therapy where there is submucosal invasion (T1b). Treatment of low grade dysplasia is not supported at present due to widespread over-reporting of the disease. The role of surveillance endoscopy in non-dysplastic Barrett's remains controversial.
Journal of gastroenterology.J Gastroenterol.2014 Feb;49(2):195-205. doi: 10.1007/s00535-013-0816-z. Epub 2013 Jun 5.
The management of Barrett's oesophagus and associated neoplasia has evolved considerably in recent years. Modern endoscopic strategies including endoscopic resection and mucosal ablation can eradicate dysplastic Barrett's and prevent progression to invasive oesophageal cancer. However, several aspec
PMID 23736794

Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study.

Suter MJ1, Gora MJ2, Lauwers GY3, Arnason T3, Sauk J4, Gallagher KA2, Kava L2, Tan KM5, Soomro AR2, Gallagher TP2, Gardecki JA2, Bouma BE6, Rosenberg M2, Nishioka NS7, Tearney GJ8.Author information 1Pulmonology and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.2Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.3Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.4Gastrointestinal Endoscopy Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.5Pulmonology and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.6Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, USA; Harvard-MIT Health Sciences and Technology, Cambridge, Massachusetts, USA.7Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Gastrointestinal Endoscopy Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.8Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Harvard-MIT Health Sciences and Technology, Cambridge, Massachusetts, USA.AbstractBACKGROUND: Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites.
Gastrointestinal endoscopy.Gastrointest Endosc.2014 Jan 23. pii: S0016-5107(13)02561-3. doi: 10.1016/j.gie.2013.11.016. [Epub ahead of print]
BACKGROUND: Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the ent
PMID 24462171