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- 1. 末梢神経障害の評価のための皮膚生検 skin biopsy for the evaluation of peripheral nerve disease
- 2. 異型線維黄色腫 atypical fibroxanthoma
- 3. 抗リン脂質抗体症候群の病因 pathogenesis of the antiphospholipid syndrome
- 4. 補体系の後天性疾患 acquired disorders of the complement system
- 5. 胎膜：解剖学および生化学 fetal membranes anatomy and biochemistry
English Journal
- Histometric changes and epidermal FGF9 expression in carbon photoenhancer-assisted Nd:YAG laser treatment.
- Zheng Z1, Kim J, Choi MJ, Goo B, Chun SI, Cho SB.Author information 1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine , Seoul , Korea.AbstractFibroblast growth factor (FGF)-9 plays an important role in wound healing. However, the effects of non-ablative laser treatment on the expression of FGF9 have not been fully investigated. Non-ablative 1064-nm quasi-long pulsed and Q-switched Nd:YAG laser treatments were delivered to hairless mice with and without a carbon photoenhancer. For histological and immunohistochemical analyses, sections were stained with hematoxylin and eosin as well as FGF9 antibody. Significantly, increased epidermal and dermal thickness was noted in mice treated with carbon photoenhancer-assisted quasi-long pulsed or Q-switched laser treatments compared to those treated without a carbon photoenhancer. Expression of FGF9 was observed in both the epidermis and dermis in all groups of mice during the healing process. Earlier and more pronounced expression of FGF9 was detected in mice treated with carbon photoenhancer-assisted quasi-long pulsed laser therapy. In addition, two peaks of pronounced FGF9 expression were observed, especially in mice that underwent carbon photoenhancer-assisted 1064-nm quasi-long pulsed Nd:YAG laser treatment. A carbon photoenhancer seems to enhance the effect of quasi-long pulsed and Q-switched Nd:YAG laser treatment. In addition, expression of FGF9 may play an important role in the healing process after laser treatments and could contribute to histometric changes.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Aug;25(4):278-82. doi: 10.3109/09546634.2012.723121. Epub 2012 Sep 19.
- Fibroblast growth factor (FGF)-9 plays an important role in wound healing. However, the effects of non-ablative laser treatment on the expression of FGF9 have not been fully investigated. Non-ablative 1064-nm quasi-long pulsed and Q-switched Nd:YAG laser treatments were delivered to hairless mice wi
- PMID 22905667
- Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival.
- Lee HS1, Chen M, Kim JH, Kim WH, Ahn S, Maeng K, Allegra CJ, Kaye FJ, Hochwald SN, Zajac-Kaye M.Author information 1Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.AbstractThymidylate synthase (TS), a critical enzyme for DNA synthesis and repair, is both a potential tumor prognostic biomarker as well as a tumorigenic oncogene in animal models. We have now studied the clinical implications of TS expression in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) and compared these results to other cell cycle biomarker genes. Protein tissue arrays were used to study TS, Ki-67, Rb, pRb, E2F1, p18, p21, p27 and menin expression in 320 human GEP-NETs samples. Immunohistochemical expression was correlated with univariate and multivariate predictors of survival utilizing Kaplan Meier and Cox proportional hazards models. Real time RT-PCR was used to validate these findings. We found that 78 of 320 GEP-NETs (24.4%) expressed TS. NETs arising in the colon, stomach and pancreas showed the highest expression of TS (47.4%, 42.6% and 37.3%, respectively), whereas NETs of the appendix, rectum and duodenum displayed low TS expression (3.3%, 12.9% and 15.4%, respectively). TS expression in GEP-NETs was associated with poorly differentiated endocrine carcinoma, angiolymphatic invasion, lymph node metastasis and distant metastasis (p < 0.05). Patients with TS-positive NETs had markedly worse outcomes than TS-negative NETs as shown by univariate (p < 0.001) and multivariate (p = 0.01) survival analyses. Expression of p18 predicted survival in TS-positive patients that received chemotherapy (p = 0.015). In conclusion, TS protein expression was an independent prognostic biomarker for GEP-NETs. The strong association of increased TS expression with aggressive disease and early death supports the role of TS as a cancer promoting agent in these tumors.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 1;135(1):128-37. doi: 10.1002/ijc.28675. Epub 2014 Jan 6.
- Thymidylate synthase (TS), a critical enzyme for DNA synthesis and repair, is both a potential tumor prognostic biomarker as well as a tumorigenic oncogene in animal models. We have now studied the clinical implications of TS expression in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) an
- PMID 24347111
- Nature and mechanisms of hepatocyte apoptosis induced by D-galactosamine/lipopolysaccharide challenge in mice.
- Wu YH1, Hu SQ1, Liu J1, Cao HC2, Xu W2, Li YJ2, Li LJ2.Author information 1Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, Department of Pharmacy, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.AbstractApoptosis plays a role in the normal development of liver. However, overactivation thereof may lead to hepatocellular damage. The aim of this study was to assess D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced hepatocyte apoptotic changes in mice and clarify the mechanisms involved in this process. DNA ladder detection was employed to determine the induction condition of hepatic apoptosis. An initial test indicated that typical hepatocyte apoptosis was observed at 6-10 h after the intraperitoneal injection of D-GalN (700 mg/kg) and LPS (10 µg/kg). Subsequently, we evaluated hepatocyte apoptosis at 8 h after administering D-GalN/LPS by histopathological analysis, terminal deoxynucleotidyl transferase-mediated dUTP nick end‑labeling (TUNEL) detection, flow cytometry and electron microscopy analysis. To clarify the apoptosis-related gene expression, the expression levels of tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), caspase-3, and Fas/Fas ligand (FasL) were determined by serum enzyme immunoassay, immunohistochemistry and western blot analysis. Strong apoptotic positive signals following D-GalN/LPS injection were observed from the results of the serum analysis, histopathological and immunohistochemical analyses, DNA ladder detection, TUNEL detection, flow cytometry and electron microscopy analysis. Additionally, apoptotic hepatocytes were mainly at the late stage of cell apoptosis. The expression of TNF-α, TGF-β1, caspase-3 and Fas/FasL was significantly increased. In conclusion, this study evaluated the D-GalN/LPS-induced hepatocyte apoptotic changes and clarified the apoptosis-related gene expression in mice. The hepatocyte apoptosis induced by D-GalN/LPS may be mainly regulated by the death receptor pathway. TGF-β signaling pathway may also play a vital role in this process of hepatocyte apoptosis.
- International journal of molecular medicine.Int J Mol Med.2014 Jun;33(6):1498-506. doi: 10.3892/ijmm.2014.1730. Epub 2014 Apr 7.
- Apoptosis plays a role in the normal development of liver. However, overactivation thereof may lead to hepatocellular damage. The aim of this study was to assess D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced hepatocyte apoptotic changes in mice and clarify the mechanisms involved in this
- PMID 24714963
Japanese Journal
- Nfkbiz regulates the proliferation and differentiation of keratinocytes
- Ishiguro-Oonuma Toshina,Ochiai Kazuhiko,Hashizume Kazuyoshi,Iwanaga Toshihiko,Morimatsu Masami
- Japanese Journal of Veterinary Research 63(3), 107-114, 2015-08
- … Immunohistochemical analyses for Ki-67 revealed that Nfkbiz－/－ keratinocytes were hypoproliferative. …
- NAID 120005656352
- Expression of SHH, PTCH and SMO to the Hedgehog signal in keratocystic odontogenic tumor
- Yamada Koji,Wato Masahiro,Tsuji Kaname,Tanaka Akio,Morita Shosuke
- Journal of Osaka Dental University 49(1), 85-93, 2015-04
- … We used immunohistochemistry, western blotting and RT-PCR analyses to examine the expression of SHH, PTCH and SMO in surgical specimens of 30 cases of KCOT, 8 cases of the orthokeratinized odontogenic cyst (OOC) and 10 cases of the dentigerous cyst (DC). … We also did immunohistochemical analyses of two different epithelial layers, the upper spinous layer and the lower basal layer. …
- NAID 110009942792
- Expression of Vasohibin-1 in Human Carotid Atherosclerotic Plaque
- Fukumitsu Ryu,Minami Manabu,Yoshida Kazumichi,Nagata Manabu,Yasui Mika,Higuchi Sei,Fujikawa Risako,Ikedo Taichi,Yamagata Sen,Sato Yasufumi,Arai Hidenori,Yokode Masayuki,Miyamoto Susumu
- Journal of Atherosclerosis and Thrombosis 22(9), 942-948, 2015
- … Finally, the immunohistochemical analyses revealed the VASH1 expression in the neointimal microvessel endothelial cells of carotid plaque.Conclusions: The VASH1 expression levels in atheroma reflect both enhanced neovascularization and the inflammatory burden. …
- NAID 130005099293
Related Links
- Immunohistochemical staining is accomplished with antibodies that recognize the target protein. Since antibodies are highly specific, the antibody will bind only to the protein of interest in the tissue section. The antibody-antigen ...
- Oestrogen, progesterone, and androgen receptors in ovarian neoplasia: correlation between immunohistochemical and biochemical receptor analyses Helena C van Doorn 1,
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| リンク元 | 「免疫組織化学法」「免疫組織化学解析」「immunohistochemical analysis」 |
| 関連記事 | 「analyses」「analyse」「immunohistochemical」 |
「免疫組織化学法」
「免疫組織化学解析」
「immunohistochemical analysis」
「analyses」
「analyse」
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- 分析する、解析する
「immunohistochemical」
- 免疫組織化学的な、免疫組織化学の