WordNet

secure against; "immune from taxation as long as he resided in Bermuda"; "immune from criminal prosecution"
a person who is immune to a particular infection
relating to or conferring immunity (to disease or infection) (同)resistant
(usually followed by `to'
relating to the condition of immunity; "the immune system"

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免疫の / 《補語にのみ用いて》(影響・攻撃・義務・税などを)免れている《+『against』(『from, to』)+『名』》
(…への)固守,執着《+『to』+『名』》 / (物が)(…に)付着する(している)こと《+『to』+『名』》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/12 00:16:46」(JST)

wiki en

Immune adherence was described by Nelson (1953)^[1] for an in vitro immunological reaction between normal erythrocytes and a wide variety of microorganisms sensitized with their individually specific antibody and complement; erythrocytes were observed to adhere to microorganisms.^[1] It was later recognized to occur in vivo.^[2]

The phenomenon is now resolved as a complement-dependent binding reaction of erythrocytes to microorganisms where specific antibodies are engaged in the process.^[3] The reaction process is as follows: any microorganisms are bound with their specific antibodies, if they are produced, which activate the classical pathway of the complement system. The cascade begins to work from C1 to C3b through C4b, C3b being further transformed to iC3b (inactive derivative of C3b), all of which, C4b and thereafter, remain to bind to the surface of the microbe. Because primate erythrocytes express complement receptor 1 (CR1) on their surface and having binding specificity to C4b, C3b, or iC3b, erythrocytes accumulate on the microbe via CR1-complement binding.^[3]^[4]

Function of the immune adherence (in vivo)[edit]

Human erythrocytes express 100 to 1,000 CR1 per cell, the average number of approximately 300 being an inherited characteristics.^[5] Immune complexes bound to erythrocytes are effectively removed from the circulation, which is presumed alternatively to prevent deposition at tissue sites, for example, the renal glomerulus. Erythrocytes bearing immune complexes traverse sinusoids of the liver and spleen, where they encounter fixed phagocytes. Phagocytes expressing CR1, CR3, and Fcγ receptors effect a transfer of the immune complexes to their surface. Then erythrocytes leave the liver and spleen bearing off immune complexes and work on the next round of transfer of immune complexes after adhering to them.^[5]^[6]^[7]^[8]

References[edit]

^ ^a ^b Nelson Jr, RA (1953). "The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis". Science 118 (3077): 733–7. doi:10.1126/science.118.3077.733. PMID 13122009.
^ Nelson Jr, RA (1956). "The immune-adherence phenomenon; a hypothetical role of erythrocytes in defence against bacteria and viruses". Proceedings of the Royal Society of Medicine 49 (1): 55–8. PMC 1889026. PMID 13289834.
^ ^a ^b Roitt IM, Brostoff J, Male D (1998). Immunology, 5th ed. London: Mosby, ISBN 0-7234-2918-9.
^ Frank K, Atkinson JP (2001). "Complement system." In Austen KF, Frank K, Atkinson JP, Cantor H. eds. Samter's Immunologic Diseases, 6th ed. Vol. 1, p. 281–298, Philadelphia: Lippincott Williams & Wilkins, ISBN 0-7817-2120-2
^ ^a ^b Walport, MJ; Lachmann, PJ (1988). "Erythrocyte complement receptor type 1, immune complexes, and the rheumatic diseases". Arthritis and rheumatism 31 (2): 153–8. doi:10.1002/art.1780310201. PMID 3279961.
^ Hebert, LA; Cosio, G (1987). "The erythrocyte-immune complex-glomerulonephritis connection in man". Kidney international 31 (4): 877–85. doi:10.1038/ki.1987.81. PMID 3295360.
^ Bala Subramanian V, Liszewski MK, Atkinson JP (2000). "The complement system and autoimmunity." In Lahita RG, Chiorazzi N, Reeves WH, eds. Textbook of the Autoimmune Diseases. Philadelphia: Lippincott Williams & Wilkins, ISBN 0-7817-1505-9.
^ Schifferli, JA; Ng, YC; Peters, DK; Peters, D. Keith (1986). "The role of complement and its receptor in the elimination of immune complexes". The New England Journal of Medicine 315 (8): 488–95. doi:10.1056/NEJM198608213150805. PMID 2942776.

UpToDate Contents

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1. 自己免疫性溶血性貧血の病因：温暖凝集素と薬剤 pathogenesis of autoimmune hemolytic anemia warm agglutinins and drugs
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3. 補体系の制御因子および受容体 regulators and receptors of the complement system
4. 補体経路 complement pathways
5. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system

English Journal

Short Communication: Effects of Age on Virologic Suppression and CD4 Cell Response in HIV-Positive Patients Initiating Combination Antiretroviral Therapy.

Szadkowski L, Tseng A, Walmsley SL, Salit I, Raboud JM.Source1 Dalla Lana School of Public Health, University of Toronto , Toronto, Canada .
AIDS research and human retroviruses.AIDS Res Hum Retroviruses.2012 Dec;28(12):1579-83. doi: 10.1089/AID.2012.0018. Epub 2012 Aug 3.
Abstract Older HIV-positive patients may experience reduced benefit and increased toxicities from combination antiretroviral therapies (cART) due to late diagnosis, weakened immune systems, and other age-related physiological changes. This study investigates the effect of age on time to virologic
PMID 22734840

Japanese Journal

現在使用されている水痘ワクチンの力価の必要性

尾崎隆男,西村直子,後藤研誠
感染症学雑誌 = The journal of Japanese the Association for Infectious Diseases 86(6), 749-754, 2012-11
NAID 40019502502

水痘ワクチンの抗体測定における免疫粘着赤血球凝集反応法の有用性

尾崎隆男,西村直子,後藤研誠
感染症学雑誌 86(2), 146-148, 2012-03
NAID 40019251202

「免疫粘着反応」

　　[★]

英: immune adherence IA
関: 免疫複合体

「免疫粘着」

　　[★]

英: immune adherence
同: 免疫付着

「IA」

　　[★] 免疫粘着反応 immune adherence

「immune adherence hemagglutination」

　　[★] 免疫粘着赤血球凝集反応

「immune adherence hemagglutination test」

　　[★] 免疫粘着血液凝集法

「adherence」

　　[★]

n.

付着、粘着。固執、厳守。忠実な支持

指示順守度（患者が，いったん了承した治療法をほとんど監視なしで継続する度合．cf.compliance(http://www.proz.com/kudoz/english_to_japanese/medical_general/1136920-patient_adherence.html)

「immune」

　　[★]

adj.

免疫の、免疫性の

関: immunisation、immunise、immunity、immunization、immunize、immuno、immunologic

[Nelson53-1] Nelson Jr, RA (1953). "The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis". Science 118 (3077): 733–7. doi:10.1126/science.118.3077.733. PMID 13122009.

[Nelson56-2] Nelson Jr, RA (1956). "The immune-adherence phenomenon; a hypothetical role of erythrocytes in defence against bacteria and viruses". Proceedings of the Royal Society of Medicine 49 (1): 55–8. PMC 1889026. PMID 13289834.

[Roitt5-3] Roitt IM, Brostoff J, Male D (1998). Immunology, 5th ed. London: Mosby, ISBN 0-7234-2918-9.

[Frank-4] Frank K, Atkinson JP (2001). "Complement system." In Austen KF, Frank K, Atkinson JP, Cantor H. eds. Samter's Immunologic Diseases, 6th ed. Vol. 1, p. 281–298, Philadelphia: Lippincott Williams & Wilkins, ISBN 0-7817-2120-2

[Walport-5] Walport, MJ; Lachmann, PJ (1988). "Erythrocyte complement receptor type 1, immune complexes, and the rheumatic diseases". Arthritis and rheumatism 31 (2): 153–8. doi:10.1002/art.1780310201. PMID 3279961.

[Hebert-6] Hebert, LA; Cosio, G (1987). "The erythrocyte-immune complex-glomerulonephritis connection in man". Kidney international 31 (4): 877–85. doi:10.1038/ki.1987.81. PMID 3295360.

[Bala-7] Bala Subramanian V, Liszewski MK, Atkinson JP (2000). "The complement system and autoimmunity." In Lahita RG, Chiorazzi N, Reeves WH, eds. Textbook of the Autoimmune Diseases. Philadelphia: Lippincott Williams & Wilkins, ISBN 0-7817-1505-9.

[Schifferli-8] Schifferli, JA; Ng, YC; Peters, DK; Peters, D. Keith (1986). "The role of complement and its receptor in the elimination of immune complexes". The New England Journal of Medicine 315 (8): 488–95. doi:10.1056/NEJM198608213150805. PMID 2942776.

リンク元	「免疫粘着反応」「免疫粘着」「IA」
拡張検索	「immune adherence hemagglutination」「immune adherence hemagglutination test」
関連記事	「adherence」「immune」

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案内

案内

immune adherence