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English Journal

The idiotypic network in the regulation of autoimmunity: Theoretical and experimental studies.

Menshikov I1, Beduleva L2, Frolov M2, Abisheva N2, Khramova T2, Stolyarova E2, Fomina K2.
Journal of theoretical biology.J Theor Biol.2015 Jun 21;375:32-9. doi: 10.1016/j.jtbi.2014.10.003. Epub 2014 Oct 24.
The regulation of autoimmunity is a key issue in fundamental immunology. Despite outstanding achievements on this front, we currently have more questions than answers. The idea of an immune network as a regulatory mechanism is quite attractive, since it enables us to explain the selectivity (specifi
PMID 25445185

Citrinin detection using phage-displayed anti-idiotypic single-domain antibody for antigen mimicry.

Xu Y1, Xiong L2, Li Y3, Xiong Y1, Tu Z1, Fu J1, Tang X1.
Food chemistry.Food Chem.2015 Jun 15;177:97-101. doi: 10.1016/j.foodchem.2015.01.007. Epub 2015 Jan 10.
Anti-idiotypic antibodies (AIds) can mimic antigen molecules and can thus offer an alternative to conventional antigens in immunoassays. In this study, citrinin (CIT) was chosen as a target analyte, and an anti-idiotypic single-domain antibody (VHH) was selected from a naïve alpaca VHHs library to
PMID 25660863

Aβ anti-idiotypic antibodies are present in intravenous immunoglobulin and are produced in mice following its administration.

Loeffler DA1, Klaver AC, Coffey MP.
Autoimmunity.Autoimmunity.2015 Jun;48(4):196-200. doi: 10.3109/08916934.2014.983265. Epub 2014 Nov 13.
The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloi
PMID 25392130

土手内靖,尾崎牧子,西山記子,長谷部淳,谷松智子,西山政孝
医学検査 64(1), 60-65, 2015
Levofloxacin（LVFX）により激しい溶血性貧血を起こしたと推測される症例を経験したので報告する。症例は69歳男性。腹痛・発熱が1週間続くため近医を受診，腸間膜リンパ節炎と診断されLVFXが処方された。2日間内服したが症状の改善なく，当院に緊急入院となり，抗生剤をLVFXからCefmetazoleに切り替えた。入院3病日，嘔気，血圧低下，褐色尿および眼球黄染が出現，血液検査で著明な貧血（ …
NAID 130005057089

安山雅子,川内喜代隆,大塚邦明 [他],田村博之,藤林真理子
日本老年医学会雑誌 51(6), 569-575, 2014
81歳男性．息切れを主訴に来院．末梢血でHb 7.0 g/dL，網状赤血球6.4%，リンパ球20,003/μL, I.Bil 3.6 mg/dL，直接クームス陽性，寒冷凝集素8,192倍，著明な脾腫を認め，PET-CTで脾臓，骨髄に異常集積を認めた．骨髄穿刺及び生検で異型性のあるリンパ球の集簇を認め，表面マーカー解析ではCD5－，CD10－，CD20＋，κ+で免疫染色上cyclin D1－であった …
NAID 130004917187

山田麻里江,山田尚友,久保田寧,木村晋也,東谷孝徳,末岡榮三朗
日本輸血細胞治療学会誌 60(1), 32-37, 2014
反応増強剤を使用した不規則抗体検査では，冷式抗体の持ちこしが原因で間接抗グロブリン試験が陽性となることをしばしば経験する．冷式抗体の持ちこしを回避し，臨床的意義のある不規則抗体であるかの判別に，反応増強剤無添加間接抗グロブリン試験（以下60min-IAT）が利用されている．今回，IgM型抗Mの結合がIgG型抗Mの結合を抑制したため，60min-IATの反応が陰性化した可能性が示唆された症例を経験し …
NAID 130004542708