anti-idiotypic

• 抗イディオタイプの

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anti-idiotype、antiidiotype、antiidiotypic

WordNet

1. not in favor of (an action or proposal etc.)
2. a person who is opposed (to an action or policy or practice etc.); "the antis smelled victory after a long battle"
3. social insect living in organized colonies; characteristically the males and fertile queen have wings during breeding season; wingless sterile females are the workers (同)emmet, pismire

PrepTutorEJDIC

1. 《話》(特定の慣習・政策・行動などに)反対する人
2. 『アリ』
3. =ain't
4. (次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/25 13:12:57」(JST)

wiki en

[Wiki en表示]

Anti-idiotypic vaccines comprise antibodies that have three-dimensional immunogenic regions, designated idiotopes, that consist of protein sequences that bind to cell receptors. Idiotopes are aggregated into idiotypes specific of their target antigen. An example of anti-idiotype antibody is Racotumomab.

Production and use

In one example of producing an anti-idiotypic vaccine, antibodies that bind tumor-associated antigens (TAA) are isolated and injected into mice. To the murine immune system, the TAA antibodies are antigens and cause an immunogenic reaction producing murine antibodies that can bind to the "TAA idiotype" and is said to be "anti-idiotypic". The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in the second set of mice have a three-dimensional binding site that mimics the original antibodies that bind tumor-associated antigens. These antibodies are combined with an adjuvant and given as a vaccine. The murine immune system essentially "amplifies" a small mass of TAA antibodies into a much larger mass used to vaccinate humans. Because the antibody produced using the "anti-idiotypic" process closely resembles the original epitope of the antigen, these antibodies can be used to induce immune responses from cellular to antibody-antigen for a given antigen, e. g., TAA, when administered as a vaccine to a human. They are mainly used for high risk cancer patients.

References

• Ansel's Pharmaceutical Dosage Forms and Drug Delivery System (Page 513) (ISBN 0-7817-4612-4)

UpToDate Contents

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• 3. 抗IgE療法 anti ige therapy
• 4. 臨床的に有用な生物学的マーカーによる関節リウマチの診断および転帰評価 clinically useful biologic markers in the diagnosis and assessment of outcome in rheumatoid arthritis
• 5. 免疫グロブリンの使用における一般原則 general principles in the use of immune globulin

English Journal

• Idiotype-specific intravenous immunoglobulin (IVIG) for therapy of autoimmune diseases.

• Blank M, Bashi T, Shoenfeld Y.SourceZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1060:353-61. doi: 10.1007/978-1-62703-586-6_18.
• Intravenous immunoglobulin (IVIG) is used successfully for therapy of inflammatory and autoimmune diseases, especially in cases of conventional therapy resistance. Within the broad spectrum of immunomodulatory activities of IVIG in vitro and in vivo, the anti-idiotypic activity, neutralizing the aut
• PMID 24037850

• Henoch-Schönlein purpura (HSP) and high-dose immunoglobulin treatment in patient with familiar prostatic adenocarcinoma.

• Sobieszczańska M, Tubek S, Poplicha D, Grabelus A, Pawełczak J.SourceDepartment of Pathophysiology; Medical University; Wrocław, Poland.
• Human vaccines & immunotherapeutics.Hum Vaccin Immunother.2013 Nov 15;10(2). [Epub ahead of print]
• A 52-y old man was admitted to our Department because of abdominal pains and diarrhea with fresh blood, with concomitant purpura over the whole body and edema of the both tarsal joints. The medical history of the patient included skin changes of similar character identified once 10-12 y before. The
• PMID 24231833

• Off-rate screening for selection of high-affinity anti-drug antibodies.

• Ylera F, Harth S, Waldherr D, Frisch C, Knappik A.SourceBio-Rad AbD Serotec GmbH, 82178 Puchheim, Germany. Electronic address: francisco.ylera@abdserotec.com.
• Analytical biochemistry.Anal Biochem.2013 Oct 15;441(2):208-13. doi: 10.1016/j.ab.2013.07.025. Epub 2013 Jul 29.
• The rapidly increasing number of therapeutic antibodies in clinical development and on the market requires corresponding detection reagents for monitoring the concentration of these drugs in patient samples and as positive controls for measurement of anti-drug antibodies. Phage display of large reco
• PMID 23906643

Japanese Journal

• Different buffer effects in selecting HM-1 killer toxin single-chain fragment variable anti-idiotypic antibodies

• Krishnaswamy Senthilkumar,Kabir M. Enamul,Miyamoto Masahiko [他],FURUICHI Yasuhiro,KOMIYAMA Tadazumi
• The journal of biochemistry 147(5), 723-733, 2010-05-01
• NAID 10027875919

• Vaccination with autoreactive CD4+Th1 clones in lupus-prone MRL/Mp-Faslpr/lpr mice

• Fujii Takao,Okada Masato,Fujita Yoshimasa,Sato Takeshi,Tanaka Masao,Usui Takashi,Umehara Hisanori,Mimori Tsuneyo
• Journal of Autoimmunity 33(2), 125-134, 2009-09
• … CD4+αβ Th1 clones, dna51 (Vβ8.3) and rnp2 (Vβ14), which stimulated anti-dsDNA or U1 ribonucleoprotein (U1RNP) antibody (Ab) production respectively, were isolated from splenocytes of MRL/lpr mice. … Anti-idiotypic humoral and T cell responses against the transferred autoreactive Th1 clones were determined in parallel. …
• NAID 120001596907

• The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS) : trophoblast invasiveness and APS animal model

• BLANK Miri,ANAFI Liat,ZANDMAN-GODDARD Gisele,KRAUSE Ilan,GOLDMAN Shlomit,SHALEV Eliezer,CERVERA Ricard,FONT Josep,FRIDKIN Mati,THIESEN Hans-Jurgen,SHOENFELD Yehuda
• International immunology 19(7), 857-865, 2007-07-01
• NAID 10020109213

Related Links

• Anti-idiotypic | Define Anti-idiotypic at Dictionary.com

Anti-idiotypic definition, a molecular arrangement on an antibody that is the counterpart of that on a different antibody, thus making one an antigen to the other. See more. Thesaurus Translator Reference Word of the Day Blog ...

• Anti-idiotypic Antibodies : BioGenes GmbH : Antibodies

BioGenes develops high-affinity anti-idiotypic antibodies that are ideal for preclinical research (PK, Tox and immunogenicity studies) and the generation of data to support the development of human antibody drugs. Anti-idiotypic ...

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リンク元	「antiidiotypic」「antiidiotype」「anti-idiotype」「抗イディオタイプ」
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関連記事	「idiotypic」「ant」「anti」

「antiidiotypic」

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• 抗イディオタイプの

関

anti-idiotype、anti-idiotypic、antiidiotype

「antiidiotype」

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• 抗イディオタイプ

関

anti-idiotype、anti-idiotypic、antiidiotypic

「anti-idiotype」

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• 抗イディオタイプ

関

anti-idiotypic、antiidiotype、antiidiotypic

「抗イディオタイプ」

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英

anti-idiotype、antiidiotype、anti-idiotypic、antiidiotypic

「anti-idiotypic antibody」

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抗イディオタイプ抗体

関

antiglobulin

「idiotypic」

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• イディオタイプの

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Id、idiotype

「ant」

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• n.

• アリ

同

ants, stinging

　 　 　

「anti」

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• comb form.

• 抗、アンチ