WordNet

having a strong affinity for water; tending to dissolve in, mix with, or be wetted by water
a semisolid mixture of hydrocarbons obtained from petroleum; used in medicinal ointments and for lubrication (同)petroleum_jelly, mineral_jelly

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1. 小児における鼻出血のマネージメント management of epistaxis in children
2. 乳幼児におけるおむつ皮膚炎の概要 overview of diaper dermatitis in infants and children
3. うっ滞性皮膚炎 stasis dermatitis
4. 放射線皮膚炎 radiation dermatitis
5. ケジラミ症と眼瞼ケジラミ症 pediculosis pubis and pediculosis ciliaris

English Journal

Prognostic factors that affect the response to topical treatment in patchy alopecia areata.

Ucak H, Cicek D, Demir B, Erden I, Ozturk S.Author information Elazig Education and Research Hospital Department of Dermatology, TR23119 Elazig, TurkeyFirat University Faculty of Medicine, Departments of Dermatology.AbstractBackground Alopecia areata (AA) is an organ-specific, T-cell-mediated autoimmune disease that is characterized by non-scarring hair loss. Objective We aimed to find the factors that may affect the response to topical therapy in AA. Methods The study included a total of 60 patients with AA and 30 healthy control patients. The AA patients were randomized into two groups. 40 patients used 0.05% clobetasol propionate cream, and 20 patients used petrolatum (placebo). Both groups applied topical treatments to their lesions twice daily for 12 weeks. Results The mean extent of AA was 21.88 ± 16.75% in patients with autoantibodies and 12.16 ± 13.55% in those who were negative for autoantibodies (P = 0.021). Ophiasic pattern and nail involvement were observed more frequently in patients with atopy (P < 0.05). Relapse was more frequent in patients with atopy (P = 0.002) and nail involvement (P = 0.02). Conclusions We observed that the presence of autoantibodies was associated with more extensive AA, and that ophiasic hair loss pattern and nail dystrophy were significantly associated with atopy. Topical clobetasol propionate treatment produced a modest advantage in hair regrowth as compared with placebo. Notably, atopic AA patients have a higher risk of relapse and redevelopment of AA after completing a course of topical corticosteroid treatment.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2014 Jan;28(1):34-40. doi: 10.1111/jdv.12043. Epub 2012 Nov 26.
Background Alopecia areata (AA) is an organ-specific, T-cell-mediated autoimmune disease that is characterized by non-scarring hair loss. Objective We aimed to find the factors that may affect the response to topical therapy in AA. Methods The study included a total of 60 patients with AA a
PMID 23181708

The use of sunscreen starting on the first day after ablative fractional skin resurfacing.

Wanitphakdeedecha R, Phuardchantuk R, Manuskiatti W.Author information Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.AbstractBACKGROUND: The most common side-effect of ablative fractional skin resurfacing in Asians is post inflammatory hyperpigmentation (PIH). Various attempts have been made to reduce the occurrence of PIH after laser treatment including sun avoidance, the use of preoperative and postoperative treatment regimens, and treatment using conservative energy settings and epidermal protection.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2013 Dec 10. doi: 10.1111/jdv.12332. [Epub ahead of print]
BACKGROUND: The most common side-effect of ablative fractional skin resurfacing in Asians is post inflammatory hyperpigmentation (PIH). Various attempts have been made to reduce the occurrence of PIH after laser treatment including sun avoidance, the use of preoperative and postoperative treatment r
PMID 24320057

Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis.

Vetchý D1, Landová H1, Gajdziok J2, Doležel P1, Daněk Z3, Stembírek J4.Author information 1Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.2Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address: gajdziokj@vfu.cz.3Clinic of Oral and Maxillofacial Surgery, University Hospital Brno, Brno, Czech Republic.4Department of Maxillo-Facial Surgery, University Hospital Ostrava, Ostrava - Poruba, Czech Republic.AbstractMucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. The addition of polyethylene oxide prolonged the in vivo film residence time (from 53.24±5.38-74.18±5.13min to 71.05±3.15-98.12±1.75min), and even more when combined with an ethylcellulose backing layer (98.12±1.75min) and also improved the film's appearance. Tested non-woven textile shortened the in vivo film residence time (from 74.18±5.13-98.12±1.75min to 53.24±5.38-81.00±8.47min) and generally worsened the film's appearance. Mucoadhesive buccal films with a hydrophobic backing layer were associated with increased frequency of adverse effects.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2013 Dec 9. pii: S0939-6411(13)00384-6. doi: 10.1016/j.ejpb.2013.12.002. [Epub ahead of print]
Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influe
PMID 24333664

Japanese Journal

Effects of topical vehicles on growth of the lipophilic Malassezia species

KOYAMA Tomoki,KANBE Toshio,KIKUCHI Akihiko,TOMITA Yasushi
Journal of dermatological science 29(3), 166-170, 2002-09-01
NAID 50000681053

タクロリムス皮内濃度測定法の確立と経皮吸収基剤検討への応用

石井澄雄,荒木博陽,三宅悟,二神幸次郎,古野勝志,黒崎勇二,川崎博己,五味田裕
医療薬学 27(2), 148-152, 2001-04-10
… We prepared tacrolimus ointments using five kinds of ointment bases, i.e., Carbopol gel, White Petrolatum, Hydrophilic Ointment, Plastibase and Macrogol ointment. … As a result, the amount of tacrolimus in the skin measured 14 hours after topical application was as follows : Carbopol gel>white Petrolatum >Hydrophilic Ointment≒Plastibase > …
NAID 110001166504

Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores

SHIGEYAMA Masato,OHGAYA Toyoaki,TAKEUCHI Hirofumi,HINO Tomoaki,KAWASHIMA Yoshiaki
Chemical & pharmaceutical bulletin 49(2), 129-133, 2001-02-01
… The sustained release function of the ointment base was obtained by adding hydrophilic petrolatum(HP) to MO. …
NAID 110003615859