ヒスチジルtRNA合成酵素、ヒスチジルtRNAシンテターゼ
- 関
- histidine-tRNA ligase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/26 16:16:29」(JST)
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| histidine-tRNA ligase |
| Identifiers |
| EC number |
6.1.1.21 |
| CAS number |
9068-78-4 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction
- ATP + L-histidine + tRNAHis AMP + diphosphate + L-histidyl-tRNAHis
The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase. This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1ADJ, 1ADY, 1H4V, 1HTT, 1KMM, 1KMN, 1QE0, 1WU7, and 1X59.
See also
References
- von Tigerstrom M, Tener GM (1967). "Histidyl transfer ribonucleic acid synthetase from bakers' yeast". Can. J. Biochem. 45 (7): 1067–74. doi:10.1139/o67-123. PMID 6035970.
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Enzymes: CO CS and CN ligases (EC 6.1-6.3)
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| 6.1: Carbon-Oxygen |
- Aminoacyl tRNA synthetase
- Tyrosine
- Tryptophan
- Threonine
- Leucine
- Isoleucine
- Lysine
- Alanine
- Valine
- Methionine
- Serine
- Aspartate
- D-alanine-poly(phosphoribitol) ligase
- Glycine
- Proline
- Cysteine
- Glutamate
- Glutamine
- Arginine
- Phenylalanine
- Histidine
- Asparagine
- Aspartate
- Glutamate
- Lysine
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| 6.2: Carbon-Sulfur |
- Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase
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| 6.3: Carbon-Nitrogen |
- Glutamine synthetase
- Ubiquitin ligase
- Cullin
- Von Hippel-Lindau tumor suppressor
- UBE3A
- Mdm2
- Anaphase-promoting complex
- UBR1
- Glutathione synthetase
- CTP synthase
- Adenylosuccinate synthase
- Argininosuccinate synthetase
- Holocarboxylase synthetase
- GMP synthase
- Asparagine synthetase
- Carbamoyl phosphate synthetase
- Gamma-glutamylcysteine synthetase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- tRNAHis-guanylyltransferase establishes tRNAHis identity.
- Heinemann IU, Nakamura A, O'Donoghue P, Eiler D, Söll D.SourceDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA, Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan and Department of Chemistry, Yale University, New Haven, CT 06520-8114, USA.
- Nucleic acids research.Nucleic Acids Res.2012 Jan;40(1):333-44. Epub 2011 Sep 2.
- Histidine transfer RNA (tRNA) is unique among tRNA species as it carries an additional nucleotide at its 5' terminus. This unusual G(-1) residue is the major tRNA(His) identity element, and essential for recognition by the cognate histidyl-tRNA synthetase to allow efficient His-tRNA(His) formation.
- PMID 21890903
- Oxidative stress-induced modifications of histidyl-tRNA synthetase affect its tRNA aminoacylation activity but not its immunoreactivity.
- van Dooren SH, Raijmakers R, Pluk H, Lokate AM, Koemans TS, Spanjers RE, Heck AJ, Boelens WC, van Venrooij WJ, Pruijn GJ.SourceDepartment of Biomolecular Chemistry, Institute for Molecules and Materials, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 271 Department of Biomolecular Chemistry, NL-6500 HB Nijmegen, The Netherlands.
- Biochemistry and cell biology = Biochimie et biologie cellulaire.Biochem Cell Biol.2011 Dec;89(6):545-53. Epub 2011 Nov 2.
- The aminoacyl-tRNA synthetases are ubiquitously expressed enzymes that catalyze the esterification of amino acids to their cognate tRNAs. Autoantibodies against several aminoacyl-tRNA synthetases are found in autoimmune polymyositis and dermatomyositis patients. Because necrosis is often found in sk
- PMID 22047085
- [Acute interstitial lung disease revealing antisynthetase syndrome].
- Bizien N, Renault A, Boles JM, Delluc A.SourceDépartement de médecine interne et pneumologie, CHU de Brest, boulevard Tanguy-Prigent, 29609 Brest cedex, France.
- Revue de pneumologie clinique.Rev Pneumol Clin.2011 Dec;67(6):367-70. Epub 2011 Apr 29.
- INTRODUCTION: The antisynthetase syndrome is characterized by the presence of myositis, interstitial lung disease, arthritis, Raynaud's phenomenon, mechanics hands and anti-Jo1 antibody (histidyl tRNA synthetase). The prognosis of this syndrome is closely related to the severity of lung disease. Myo
- PMID 22137282
Japanese Journal
- 抗Jo-1(ヒスチジルtRNA合成酵素)抗体 (広範囲 血液・尿化学検査 免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査 自己抗体)
- Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
- Myositis induced by naked DNA immunization with the gene for histidyl-tRNA synthetase
Related Links
- 1. Biol Chem. 1999 Jun;380(6):623-46. Histidyl-tRNA synthetase. Freist W, Verhey JF, Rühlmann A, Gauss DH, Arnez JG. Max-Planck-Institut für experimentelle Medizin, Abteilung Molekulare Biologie Neuronaler Signale, Göttingen ...
- Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in ...
★リンクテーブル★
[★]
- 英
- histidyl-tRNA synthetase
- 関
- ヒスチジンtRNAリガーゼ、ヒスチジルtRNAシンテターゼ
[★]
- 英
- histidyl-tRNA synthetase
- 関
- ヒスチジルtRNA合成酵素
[★]
ヒスチジンtRNAリガーゼ
- 関
- histidyl-tRNA synthetase
[★]
- 関
- ligase、synthase
[★]
トランスファーRNA, transfer RNA, 転位RNA
[★]
トランスファーRNA transfer RNAs