ヒスタミン-N-メチル基転移酵素、ヒスタミン-N-メチルトランスフェラーゼ、ヒスタミンN-メチルトランスフェラーゼ
- 同
- HNMT
WordNet
- amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- ヒスタミン(子宮収縮・血圧降下の薬)
- nitrogenの化学記号
- neodymiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/19 16:50:14」(JST)
[Wiki en表示]
| Histamine N-methyltransferase |
Crystallographic structure of human histamine N-methyltransferase.[1] |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1JQD, 1JQE, 2AOT, 2AOU, 2AOV, 2AOW, 2AOX
|
|
|
| Identifiers |
| Symbols |
HNMT ; HMT; HNMT-S1; HNMT-S2 |
| External IDs |
OMIM: 605238 HomoloGene: 5032 GeneCards: HNMT Gene |
| EC number |
2.1.1.8 |
| Gene ontology |
| Molecular function |
• histamine N-methyltransferase activity
|
| Cellular component |
• nucleus
• nucleolus
• cytoplasm
• neuron projection
|
| Biological process |
• response to tumor cell
• hyperosmotic response
• brain development
• respiratory gaseous exchange
• response to amine stimulus
• response to cocaine
• response to glucocorticoid stimulus
• response to interleukin-1
|
| Sources: Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
3176 |
140483 |
|
| Ensembl |
ENSG00000150540 |
ENSMUSG00000026986 |
|
| UniProt |
P50135 |
Q91VF2 |
|
| RefSeq (mRNA) |
NM_001024074 |
NM_080462 |
|
| RefSeq (protein) |
NP_001019245 |
NP_536710 |
|
| Location (UCSC) |
Chr 2:
138.72 – 138.77 Mb |
Chr 2:
24 – 24.05 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
| histamine N-methyltransferase |
| Identifiers |
| EC number |
2.1.1.8 |
| CAS number |
9029-80-5 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Histamine N-methyltransferase (HMT, HNMT) is an enzyme that in humans is encoded by the HNMT gene.[2]
Histamine N-methyltransferase is one of two enzymes involved in the metabolism of histamine, the other being diamine oxidase. Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N-methylhistamine. HMT is present in most body tissues but is not present in serum.[3] Histamine N-methyltransferase is encoded by a single gene which has been mapped to chromosome 2.
Contents
- 1 Function
- 2 References
- 3 Further reading
- 4 External links
Function
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.[2]
References
- ^ PDB 1JQD; Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X (September 2001). "Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons". Structure 9 (9): 837–49. doi:10.1016/S0969-2126(01)00643-8. PMID 11566133.
- ^ a b "Entrez Gene: Histamine N-methyltransferase".
- ^ Brown DD, Tomchick R, Axelrod J (November 1959). "The distribution and properties of a histamine-methylating enzyme" (pdf). J. Biol. Chem. 234 (11): 2948–50. PMID 13804910.
Further reading
- Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R (August 2002). "Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP)". Biochem. Pharmacol. 64 (4): 699–710. doi:10.1016/s0006-2952(02)01223-6. PMID 12167489.
- García-Martín E, Martínez C, Benito-León J, Calleja P, Díaz-Sánchez M, Pisa D, Alonso-Navarro H, Ayuso-Peralta L, Torrecilla D, Agúndez JA, Jiménez-Jiménez FJ (February 2010). "Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis". Eur. J. Neurol. 17 (2): 335–8. doi:10.1111/j.1468-1331.2009.02720.x. PMID 19538200.
- Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR (December 2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482.
- Seip RL, Volek JS, Windemuth A, Kocherla M, Fernandez ML, Kraemer WJ, Ruaño G (2008). "Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat". Nutr Metab (Lond) 5: 4. doi:10.1186/1743-7075-5-4. PMC 2270845. PMID 18254975.
- Chen GL, Zhu B, Nie WP, Xu ZH, Tan ZR, Zhou G, Liu J, Wang W, Zhou HH (September 2004). "Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer". Inflamm. Res. 53 (9): 484–8. doi:10.1007/s00011-004-1290-0. PMID 15551002.
- Szczepankiewicz A, Bręborowicz A, Sobkowiak P, Popiel A (2010). "Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study". Clin Mol Allergy 8: 14. doi:10.1186/1476-7961-8-14. PMC 2990726. PMID 21040557.
- Stevenson J, Sonuga-Barke E, McCann D, Grimshaw K, Parker KM, Rose-Zerilli MJ, Holloway JW, Warner JO (September 2010). "The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms". Am J Psychiatry 167 (9): 1108–15. doi:10.1176/appi.ajp.2010.09101529. PMID 20551163.
- Aksoy S, Raftogianis R, Weinshilboum R (February 1996). "Human histamine N-methyltransferase gene: structural characterization and chromosomal location". Biochem. Biophys. Res. Commun. 219 (2): 548–54. doi:10.1006/bbrc.1996.0271. PMID 8605025.
- Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X (September 2001). "Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons". Structure 9 (9): 837–49. doi:10.1016/S0969-2126(01)00643-8. PMID 11566133.
External links
- Histamine N-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Transferase: one carbon transferases (EC 2.1)
|
|
| 2.1.1: Methyl- |
| N- |
- Histamine N-methyltransferase
- Phenylethanolamine N-methyltransferase
- Amine N-methyltransferase
- Phosphatidylethanolamine N-methyltransferase
|
|
| O- |
- 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase
- Catechol-O-methyl transferase
|
|
| Homocysteine |
- Betaine-homocysteine methyltransferase
- Homocysteine methyltransferase
- Methionine synthase
|
|
| Other |
- Phosphatidyl ethanolamine methyltransferase
- DNMT3B
- Histone methyltransferase
- Thymidylate synthase
- DNA methyltransferase
- Thiopurine methyltransferase
|
|
|
2.1.2: Hydroxymethyl-,
Formyl- and Related |
| Hydroxymethyltransferase |
- Serine hydroxymethyltransferase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
|
|
| Formyltransferase |
- Phosphoribosylglycinamide formyltransferase
- Inosine monophosphate synthase
|
|
| Other |
- Glutamate formimidoyltransferase
- Aminomethyltransferase
|
|
|
| 2.1.3: Carboxy- and Carbamoyl |
| Carboxy |
- methylmalonyl-CoA carboxytransferase
|
|
| Carbamoyl |
- Aspartate carbamoyltransferase
- Ornithine carbamoyltransferase
- Oxamate carbamoyltransferase
- Putrescine carbamoyltransferase
- 3-hydroxymethylcephem carbamoyltransferase
- Lysine carbamoyltransferase
- N-acetylornithine carbamoyltransferase
|
|
|
| 2.1.4: Amidino |
- Arginine:glycine amidinotransferase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
- Metabolism: amino acid metabolism
- neurotransmitter enzymes
|
|
| monoamine |
| histidine → histamine |
| anabolism: |
|
|
| catabolism: |
- Histamine N-methyltransferase
- Amine oxidase
|
|
|
| tyrosine→dopamine→epinephrine |
| anabolism: |
- Tyrosine hydroxylase
- Aromatic L-amino acid decarboxylase
- Dopamine beta hydroxylase
- Phenylethanolamine N-methyltransferase
|
|
| catabolism: |
- Catechol-O-methyl transferase
- Monoamine oxidase
|
|
|
| glutamate→GABA |
| anabolism: |
|
|
| catabolism: |
- 4-aminobutyrate transaminase
|
|
|
| tryptophan→serotonin→melatonin |
- Tryptophan hydroxylase
- Aromatic L-amino acid decarboxylase
- Acetylserotonin O-methyltransferase
|
|
|
| arginine→NO |
- Nitric oxide synthase (NOS1, NOS2, NOS3)
|
|
| choline→Acetylcholine |
| anabolism: |
- Choline acetyltransferase
|
|
| catabolism: |
- Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
|
|
|
|
|
mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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Histaminergics
|
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Receptor
(ligands)
|
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H1
|
- Agonists: 2-Pyridylethylamine
- Betahistine
- Histamine
- HTMT
- UR-AK49
Antagonists: 1st generation: 4-Methyldiphenhydramine
- Alimemazine
- Antazoline
- Azatadine
- Bamipine
- Benzatropine/Benztropine
- Bepotastine
- Bromazine
- Brompheniramine
- Buclizine
- Captodiame
- Carbinoxamine
- Chlorcyclizine
- Chloropyramine
- Chlorothen
- Chlorphenamine
- Chlorphenoxamine
- Cinnarizine
- Clemastine
- Clobenzepam
- Clocinizine
- Cyclizine
- Cyproheptadine
- Dacemazine
- Deptropine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Dimetindene
- Diphenhydramine
- Diphenylpyraline
- Doxylamine
- Embramine
- Etodroxizine
- Etybenzatropine/Ethylbenztropine
- Etymemazine
- Flunarizine
- Histapyrrodine
- Homochlorcyclizine
- Hydroxyethylpromethazine
- Hydroxyzine
- Isopromethazine
- Isothipendyl
- Meclozine
- Mepyramine/Pyrilamine
- Mequitazine
- Methafurylene
- Methapyrilene
- Methdilazine
- Moxastine
- Niaprazine
- Orphenadrine
- Oxatomide
- Oxomemazine
- Phenindamine
- Pheniramine
- Phenyltoloxamine
- Pimethixene
- Piperoxan
- Pipoxizine
- Promethazine
- Propiomazine
- Pyrrobutamine
- Talastine
- Thenalidine
- Thenyldiamine
- Thiazinamium
- Thonzylamine
- Tolpropamine
- Tripelennamine
- Triprolidine; 2nd generation: Acrivastine
- Alinastine
- Astemizole
- Azelastine
- Bamirastine
- Barmastine
- Bepiastine
- Bepotastine
- Bilastine
- Cabastinen
- Carebastine
- Cetirizine
- Clemastine
- Clemizole
- Clobenztropine
- Dorastine
- Ebastine
- Emedastine
- Epinastine
- Flezelastine
- Ketotifen
- Latrepirdine
- Levocabastine
- Linetastine
- Loratadine
- Mapinastine
- Mebhydrolin
- Mizolastine
- Moxastine
- Noberastine
- Octastine
- Olopatadine
- Perastine
- Piclopastine
- Rocastine
- Rupatadine
- Setastine
- Talastine
- Temelastine
- Terfenadine
- Zepastine; 3rd generation: Desloratadine
- Fexofenadine
- Levocetirizine; Ungrouped: Belarizine
- Efletirizine
- Elbanizine
- Flotrenizine
- Medrylamine
- Napactadine
- Pibaxizine
- Tagorizine
- Trelnarizine
- Trenizine
- Vapitadine; Miscellaneous: Tricyclic antidepressants (amitriptyline,
- doxepin,
- trimipramine, etc)
- Tetracyclic antidepressants (mianserin,
- mirtazapine, etc)
- Typical antipsychotics (chlorpromazine,
- thioridazine, etc)
- Atypical antipsychotics (clozapine,
- olanzapine,
- quetiapine, etc)
|
|
|
H2
|
- Agonists: Amthamine
- Betazole
- Dimaprit
- Histamine
- HTMT
- Impromidine
- UR-AK49
Antagonists: Bisfentidine
- Burimamide
- Cimetidine
- Dalcotidine
- Donetidine
- Ebrotidine
- Etintidine
- Famotidine
- Lafutidine
- Lamtidine
- Lavoltidine/Loxtidine
- Lupitidine
- Metiamide
- Mifentidine
- Niperotidine
- Nizatidine
- Osutidine
- Oxmetidine
- Pibutidine
- Quisultazine/Quisultidine
- Ramixotidine
- Ranitidine
- Roxatidine
- Sufotidine
- Tiotidine
- Tuvatidine
- Venritidine
- Xaltidine
|
|
|
H3
|
- Agonists: α-Methylhistamine
- Cipralisant
- Histamine
- Imetit
- Immepip
- Immethridine
- Methimepip
- Proxyfan
Antagonists: A-349,821
- A-423,579
- ABT-239
- Betahistine
- Burimamide
- Ciproxifan
- Clobenpropit
- Conessine
- GSK-189,254
- Impentamine
- Iodophenpropit
- JNJ-5,207,852
- MK-0249
- NNC-38-1,049
- PF-03654746
- Pitolisant
- SCH-79,687
- Thioperamide
- VUF-5,681
|
|
|
H4
|
- Agonists: 4-Methylhistamine
- α-Methylhistamine
- Histamine
- VUF-8,430
Antagonists: JNJ-7,777,120
- Thioperamide
- VUF-6,002
|
|
|
Transporter
(blockers)
|
|
VMAT
|
- Ibogaine
- Reserpine
- Tetrabenazine
|
|
|
Enzyme
(inhibitors)
|
|
HDC
|
- Catechin
- Meciadanol
- Naringenin
- Tritoqualine
|
|
|
HNMT
|
- Amodiaquine
- Diphenhydramine
- Harmaline
- Metoprine
- Quinacrine
- SKF-91,488
- Tacrine
|
|
|
DAO
|
|
|
|
|
Others
|
|
Endogenous
|
- Histamine; Precursors: L-Histidine; Cofactors: Vitamin B6
|
|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
UpToDate Contents
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English Journal
- Predicting targets of compounds against neurological diseases using cheminformatic methodology.
- Nikolic K1, Mavridis L, Bautista-Aguilera OM, Marco-Contelles J, Stark H, do Carmo Carreiras M, Rossi I, Massarelli P, Agbaba D, Ramsay RR, Mitchell JB.
- Journal of computer-aided molecular design.J Comput Aided Mol Des.2015 Feb;29(2):183-98. doi: 10.1007/s10822-014-9816-1. Epub 2014 Nov 26.
- Recently developed multi-targeted ligands are novel drug candidates able to interact with monoamine oxidase A and B; acetylcholinesterase and butyrylcholinesterase; or with histamine N-methyltransferase and histamine H3-receptor (H3R). These proteins are drug targets in the treatment of depression,
- PMID 25425329
- The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.
- Song TY1, Lim J1, Kim B2, Han JW1, Youn HD3, Cho EJ4.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Aug 22;451(2):308-13. doi: 10.1016/j.bbrc.2014.07.113. Epub 2014 Aug 1.
- Menin is a gene product of multiple endocrine neoplasia type1 (Men1), an inherited familial cancer syndrome characterized by tumors of endocrine tissues. To gain insight about how menin performs an endocrine cell-specific tumor suppressor function, we investigated the possibility that menin was inte
- PMID 25088994
- Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro.
- Kuefner MA1, Feurle J2, Petersen J3, Uder M4, Schwelberger HG2.
- Allergologia et immunopathologia.Allergol Immunopathol (Madr).2014 Jul-Aug;42(4):324-8. doi: 10.1016/j.aller.2013.01.002. Epub 2013 Apr 8.
- BACKGROUND: Iodinated contrast media can cause pseudoallergic reactions associated with histamine release in significant numbers of patients. To clarify whether these adverse reactions may be aggravated by a compromised histamine catabolism we asked if radiographic contrast agents in vitro inhibit t
- PMID 23578781
Japanese Journal
- ヒスタミンN-メチル基転移酵素の発現とシグナル伝達,分化およびアポトーシス誘導への作用
- 任 几凭,木村 信也,竹村 基彦
- 兵庫医科大学医学会雑誌 32(1), 67-75, 2007-12
- … 生理活性物質であるヒスタミンを分解する酵素であるヒスタミンN-メチル基転移酵素(HMT)は,哺乳動物においては動物種や臓器によってその活性は異なっていることが知られているが,培養細胞における発現に関しては未知であった.そこで,20種類の培養細胞におけるHMTの発現を調べたところ,HeLaとMeWo細胞におけるHMTの発現が多く,AZ521, HCT15, 293T,P815とPC-12細胞におけるHMTの発現は検出されなかった.HMTの抗体を作成してマウス …
- NAID 110006992572
- Recent Advances in Molecular Pharmacology of the Histamine Systems : Organic Cation Transporters as a Histamine Transporter and Histamine Metabolism
- OGASAWARA Masahito,YAMAUCHI Kohei,SATOH Yoh-ichi,YAMAJI Ryoichi,INUI Kenichi,JONKER Johan W.,SCHINKEL Alfred H.,MAEYAMA Kazutaka
- Journal of pharmacological sciences 101(1), 24-30, 2006-05-20
- … Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. … HNMT seems to be localized in the cytoplasm, but histamine is unable to easily enter the intracellular space. …
- NAID 10018237241
Related Links
- ヒスタミン N-メチル基転移酵素の発現とシグナル伝達,分化およびアポトーシス誘導への作用 任 几凭 , 木村 信也 , 竹村 基彦
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★リンクテーブル★
[★]
- 英
- histamine N-methyltransferase
- 関
- ヒスタミン-N-メチルトランスフェラーゼ
[★]
- 英
- histamine N-methyltransferase
- 関
- ヒスタミン-N-メチル基転移酵素
[★]
- 英
- histamine N-methyltransferase
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
メチルトランスフェラーゼ、メチル基転移酵素、メチル化酵素
[★]
[★]
メチルトランスフェラーゼ
[★]
ネオジム neodymium