WordNet

a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine (同)T

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1. 分子遺伝学の原理 principles of molecular genetics
2. 成人および思春期における淋菌感染症の臨床症状および診断 clinical manifestations and diagnosis of neisseria gonorrhoeae infection in adults and adolescents
3. 小児における腎結石症の疫学および危険因子 epidemiology of and risk factors for nephrolithiasis in children
4. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
5. Macrocytosis/Macrocytic anemia

Milano G1.
Scandinavian journal of clinical and laboratory investigation.Scand J Clin Lab Invest.2016 Jul 25:1-4. [Epub ahead of print]
BACKGROUND: Sequencing of DPYD exome was conducted in a prospective cohort of advanced breast cancer patients receiving capecitabine.METHODS: A total of 243 patients were analyzed. Digestive, neurologic and hematotoxicity over cycles 1-2 showed 10.3% G3 and 2.1% G4, including one toxic death. DPYD e
PMID 27454530

Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma.

Jacobs BA1, Rosing H2, de Vries N2, Meulendijks D3, Henricks LM3, Schellens JH4, Beijnen JH5.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Jul 15;126:75-82. doi: 10.1016/j.jpba.2016.04.039. Epub 2016 Apr 29.
Quantification of the endogenous dihydropyrimidine dehydrogenase (DPD) substrate uracil (U) and the reaction product dihydrouracil (UH2) in plasma might be suitable for identification of patients at risk of fluoropyrimidine-induced toxicity as a result of DPD deficiency. In this paper, we describe t
PMID 27179185

Endogenous plasma and salivary uracil to dihydrouracil ratios and DPYD genotyping as predictors of severe fluoropyrimidine toxicity in patients with gastrointestinal malignancies.

Galarza AF1, Linden R2, Antunes MV3, Hahn RZ2, Raymundo S2, da Silva AC2, Staggemeier R2, Spilki FR2, Schwartsmann G1.
Clinical biochemistry.Clin Biochem.2016 Jul 11. pii: S0009-9120(16)30136-9. doi: 10.1016/j.clinbiochem.2016.07.004. [Epub ahead of print]
OBJECTIVE: The aim of this study was to evaluate the use of plasma and saliva uracil (U) to dihydrouracil (UH2) metabolic ratio and DPYD genotyping, as a means to identify patients with dihydropyrimidine dehydrogenase (DPD) deficiency and fluoropyrimidine toxicity.METHODS: Paired plasma and saliva s
PMID 27399164