- 日
- 関
WordNet
- permission to proceed; "the plane was given clearance to land"
- the distance by which one thing clears another; the space between them
- pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"
PrepTutorEJDIC
- 〈U〉〈C〉(…の)取り片付け,除去,掃除《+『of』+『名』》 / 〈U〉〈C〉(積荷の)通関手続き,(船の)出港免状 / (またclearance sale)〈C〉大棚ざらいの売出し / 〈U〉〈C〉(手形の)決済,(小切手の)現金化 / 〈U〉〈C〉(二つの物の間の)あき,余裕;(特に)道路面・川の面から橋げたまでの高さ / 〈U〉〈C〉秘密情報の使用許可;(秘密情報を扱う人の)信頼性調査;公安調査
- 肝臓の;肝臓にきく,肝臓のような色の
UpToDate Contents
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English Journal
- Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus™.
- Sun F1, Lee L2, Zhang Z3, Wang X3, Yu Q4, Duan X5, Chan E6.
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2015 Sep 18;77:290-302. doi: 10.1016/j.ejps.2015.06.021. Epub 2015 Jun 25.
- DZNep is a potential epigenetic drug, and exerts potent anti-proliferative and pro-apoptotic effects on broad-spectrum carcinomas via disruption of the EZH2 pathway. Antitumor studies on DZNep have been stuck in the preclinical phase because of the lack of information about its integral pharmacokine
- PMID 26116990
- Synthesis, relaxation properties and in vivo assessment of a carborane-GdDOTA-monoamide conjugate as an MRI blood pool contrast agent.
- Goswami LN1, Cai Q, Ma L, Jalisatgi SS, Hawthorne MF.
- Organic & biomolecular chemistry.Org Biomol Chem.2015 Sep 7;13(33):8912-8. doi: 10.1039/c5ob00876j. Epub 2015 Jul 24.
- The synthesis, relaxivity measurements and in vivo assessment of a carborane-GdDOTA-monoamide (CB-GdDOTA-MA) amphiphilic conjugate as a blood pool contrast agent (BPCA) is reported. This BPCA exhibited excellent binding (87.4%) with human serum albumin (HSA) and showed a higher relaxivity value (r1
- PMID 26204958
- Resection Margin and Survival in 2368 Patients Undergoing Hepatic Resection for Metastatic Colorectal Cancer: Surgical Technique or Biologic Surrogate?
- Sadot E1, Groot Koerkamp B, Leal JN, Shia J, Gonen M, Allen PJ, DeMatteo RP, Kingham TP, Kemeny N, Blumgart LH, Jarnagin WR, DʼAngelica MI.
- Annals of surgery.Ann Surg.2015 Sep;262(3):476-85. doi: 10.1097/SLA.0000000000001427.
- OBJECTIVES: The impact of margin width on overall survival (OS) in the context of other prognostic factors after resection for colorectal liver metastases is unclear. We evaluated the relationship between resection margin and OS utilizing high-resolution histologic distance measurements.METHODS: A s
- PMID 26258316
Japanese Journal
- Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease
- Kato Ken-ichiro,Takeshita Yumie,Misu Hirofumi,Zen Yoh,Kaneko Shuichi,Takamura Toshinari
- Journal of Diabetes Investigation 6(2), 158-163, 2015-03-01
- … Hepatic and skeletal muscle insulin resistance indices (hepatic insulin resistance index and Matsuda index, respectively) were calculated from 75-g oral glucose tolerance test data, and metabolic clearance rate was measured using the euglycemic hyperinsulinemic clamp method. … Results: The degree of hepatic steatosis, and grade and stage of non-alcoholic steatohepatitis were significantly correlated with Matsuda index (steatosis r = -0.45, P < …
- NAID 120005593987
- Effects of Menthol on the Pharmacokinetics of Triazolam and Phenytoin
- Hoshino Motohiro,Ikarashi Nobutomo,Hirobe Ryuta,Hayashi Mami,Hiraoka Hironori,Yokobori Kohsuke,Ochiai Takumi,Kusunoki Yoshiki,Kon Risako,Tajima Masataka,Ochiai Wataru,Sugiyama Kiyoshi
- Biological and Pharmaceutical Bulletin advpub(0), 2015
- … In the menthol-treated group, the area under the blood concentration-time curve (AUC) of triazolam was lower and its clearance was higher compared with the control group. … Similarly, the AUC of phenytoin was lower and the hepatic CYP2C expression level was higher in the menthol-treated group. …
- NAID 130004872293
- Relationship between the Concentration of Anti-polyethylene Glycol (PEG) Immunoglobulin M (IgM) and the Intensity of the Accelerated Blood Clearance (ABC) Phenomenon against PEGylated Liposomes in Mice
- Hashimoto Yosuke,Shimizu Taro,Abu Lila Amr Selim [他],Ishida Tatsuhiro,Kiwada Hiroshi
- Biological and Pharmaceutical Bulletin 38(3), 417-424, 2015
- … However, many reports have demonstrated that the intravenous injection of sterically stabilized PEGylated liposome (SL) causes an accelerated blood clearance (ABC) of subsequent doses via anti-PEG immunoglobulin M (IgM)-mediated complement activation. … In the present study, the relationships between serum anti-PEG IgM concentration, the intensity of complement activation and the hepatic clearance of SL were quantitatively investigated for their role in the ABC phenomenon. …
- NAID 130004872284
Related Links
- Hepatic clearance The systemic clearance, CL, is a measure of the efficiency with which a drug is irreversibly removed from the body. Under first order conditions, clearance can be calculated as:- Single dose Equation XVII-1 Clearance ...
- hepatic clearance Therapeutics The hypothetical calculation of the volume of distribution in liters of unmetabolized drug cleared through the liver in 1 min–L ... Title: CPX-351 Markedly Reduces Renal and Hepatic Clearance Rates for ...
★リンクテーブル★
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- 英
- 関
- 英
- hepatic clearance
- 英
- hepatic clearance
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- 関
- hepato、hepatogenic、liver
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クリアランス