WordNet

utter `hem or `ahem
the edge of a piece of cloth; especially the finished edge that has been doubled under and stitched down; "the hem of her dress was stained"; "let down the hem"; "he stitched weights into the curtains hem"; "it seeped along the hem of his jacket"
the utterance of a sound similar to clearing the throat; intended to get attention, express hesitancy, fill a pause, hide embarrassment, warn a friend, etc. (同)ahem
fold over and sew together to provide with a hem; "hem my skirt"
the 5th letter of the Hebrew alphabet
a trodden path (同)footpath
a complex red organic pigment containing iron and other atoms to which oxygen binds (同)haem, hematin, haemitin, protoheme
of or relating to biosynthesis

PrepTutorEJDIC

(折り返して縫った衣類や布の)へり,縁 / (一般に)へり,縁 / 〈布・着物〉‘の'へりを折り返して縫う;…‘の'縁どりをする
へん!えへん!(注意・疑い・ちゅうちょ・当惑などを表するための発声) / へん(えへん)と言う,せき払いをする
彼は,彼が / 《指す人の性別が分からないか,または分かる必要のない場合に》その人,あの人,自分 / 《he who(that)の形で》《文》…するものはだれでも / (動物の)おす(雄)
鬼ごっこ(tag,tick,tig)
道,小道(path)

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Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.

Homedan C1, Schmitt C2, Laafi J3, Gueguen N4, Desquiret-Dumas V4, Lenglet H5, Karim Z5, Gouya L2, Deybach JC2, Simard G1, Puy H2, Malthièry Y1, Reynier P6.
Human molecular genetics.Hum Mol Genet.2015 Sep 1;24(17):5015-23. doi: 10.1093/hmg/ddv222. Epub 2015 Jun 12.
Acute intermittent porphyria (AIP), an autosomal dominant metabolic disease (MIM #176000), is due to a deficiency of hydroxymethylbilane synthase (HMBS), which catalyzes the third step of the heme biosynthetic pathway. The clinical expression of the disease is mainly neurological, involving the auto
PMID 26071363

Gasson T1, Klein K.
The Nurse practitioner.Nurse Pract.2015 Aug 15;40(8):1-6. doi: 10.1097/01.NPR.0000469257.36238.36.
Porphyrias are inherited metabolic disorders that involve alterations in enzymes utilized in the heme biosynthetic pathway. Most of these conditions are inherited; however, some are believed to be acquired through environmental exposures. Patients with porhyrias often present with a wide range of cl
PMID 26180905

藤原亨,張替秀郎
臨床血液 56(2), 119-127, 2015
ヘムは全ての細胞で必須の分子であるが，その主な産生細胞は赤芽球と肝細胞である。ヘム生合成の障害があると，組織への酸素輸送，ミトコンドリアでの酸化的リン酸化，薬物代謝等に重大な障害を生じ，その結果，ポルフィリン症と総称される一群の疾患を生じる。本疾患は，肝細胞におけるヘム生合成の障害を認める肝性ポルフィリン症と，赤芽球でヘム合成の障害を生じる造血性ポルフィリン症に大別される。一方，赤芽球におけるヘム …
NAID 130004920717

Molecular Mechanism for Heme-Mediated Inhibition of 5-Aminolevulinic Acid Synthase 1

, , , ,
Bulletin of the Chemical Society of Japan 87(9), 997-1004, 2014
… Mammalian 5-aminolevulinic acid synthase 1 (ALAS1), an isozyme expressed in all cell types, catalyzes the first reaction in the heme biosynthetic pathway in mitochondria. … Heme regulates ALAS1 function at multiple levels including the regulation of transcription, translation, mitochondrial import, protein degradation, and enzyme activity to maintain intracellular heme concentrations in an appropriate range. …
NAID 130004153311