WordNet
- a trodden path (同)footpath
- production of a chemical compound by a living organism (同)biogenesis
PrepTutorEJDIC
- 道,小道(path)
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- 1. 視神経膠腫 optic pathway glioma
- 2. 副腎ステロイド生合成 adrenal steroid biosynthesis
- 3. 止血の概要 overview of hemostasis
- 4. 第VIII因子および第IX因子の生物学と正常な機能 biology and normal function of factor viii and factor ix
- 5. 補体系の遺伝性疾患 inherited disorders of the complement system
English Journal
- The effects of high fat, low carbohydrate and low fat, high carbohydrate diets on tumor necrosis factor superfamily proteins and proinflammatory cytokines in C57BL/6 mice.
- Sirjani M1, Taleban FA2, Hekmatdoost A3, Amiri Z4, Pellizzon M5, Hedayati M6, Bidad K7, Shokouhi Shoormasti R8, Pourpak Z9.Author information 1Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mahshidsrjn@gmail.com.2Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. talebanfa@yahoo.com.3Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a_hekmat2000@yahoo.com.4Department of Basic Sciences/Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Amiri_z@hotmail.com.5Research Diets, Inc., New Jersey, the United States of America. pourpakz@sina.tums.ac.ir.6Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hedayati47@gmail.com.7Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. katayoonb@yahoo.com.8Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. rshokouhi@farabi.tums.ac.ir.9Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. pourpakz@sina.tums.ac.ir.AbstractThere has been considerable inconsistency regarding the potential relationship between dyslipidemia and bone metabolism. The inflammatory stimulation through the receptor activator of the nuclear factor kappa-B ligand (RANKL)/ receptor activator of the nuclear factor kappa-B (RANK)/ osteoprotegerin (OPG) pathway could be the infrastructural mechanism for hypercholesterolemia-induced bone loss.In this study, we investigated the effect of dyslipidemia on RANKL and OPG alongside with pro-inflammatory cytokines. Thirty male C57Bl/6 mice (4 weeks old) were randomized to two purified diet groups (15 animals in each group), high fat, low carbohydrate diet (HFLCD) and its matched low fat, high carbohydrate diet (LFHCD). After 12 weeks of feeding in standard situations, the plasma concentration of lipid profile, interleukin (IL)1Beta,, IL-6, tumor necrosis factor-alpha (TNF-α) and RANKL, OPG, and RANKL: OPG ratio were measured.In the present study, although the body weight significantly increased during 12 weeks in HFLCD and LFHCD groups, there were no significant differences in food intake, food efficiency ratio and weight gain between the two groups. The LFHCD group had significantly higher median RANKL and RANKL/OPG ratio. There was no significant difference in plasma IL-1β, IL-6 and TNF-α concentration between LFHCD and HFLCD groups.These unexpected findings from LFHCD, that seem to be as a result of its higher carbohydrate proportion in comparison to HFLCD, implicate dietary carbohydrate rather than dietary fat as a more significant nutritional factor contributing to change in RANKL level and RANKL: OPG ratio.
- Iranian journal of allergy, asthma, and immunology.Iran J Allergy Asthma Immunol.2014 Aug;13(4):247-55.
- There has been considerable inconsistency regarding the potential relationship between dyslipidemia and bone metabolism. The inflammatory stimulation through the receptor activator of the nuclear factor kappa-B ligand (RANKL)/ receptor activator of the nuclear factor kappa-B (RANK)/ osteoprotegerin
- PMID 24659160
- Conserved water-mediated recognition and dynamics of NAD(+) (carboxamide group) to hIMPDH enzyme: water mimic approach toward the design of isoform-selective inhibitor.
- Bairagya HR1, Mishra DK, Mukhopadhyay BP, Sekar K.Author information 1a Department of Chemistry , National Institute of Technology , Durgapur , West Bengal , 713209 , India .AbstractInosine monophosphate dehydrogenase (IMPDH) enzyme involves in GMP biosynthesis pathway. Type I hIMPDH is expressed at lower levels in all cells, whereas type II is especially observed in acute myelogenous leukemia, chronic myelogenous leukemia cancer cells, and 10 ns simulation of the IMP-NAD(+) complex structures (PDB ID. 1B3O and 1JCN) have revealed the presence of a few conserved hydrophilic centers near carboxamide group of NAD(+). Three conserved water molecules (W1, W, and W1') in di-nucleotide binding pocket of enzyme have played a significant role in the recognition of carboxamide group (of NAD(+)) to D274 and H93 residues. Based on H-bonding interaction of conserved hydrophilic (water molecular) centers within IMP-NAD(+)-enzyme complexes and their recognition to NAD(+), some covalent modification at carboxamide group of di-nucleotide (NAD(+)) has been made by substituting the -CONH2group by -CONHNH2 (carboxyl hydrazide group) using water mimic inhibitor design protocol. The modeled structure of modified ligand may, though, be useful for the development of antileukemic agent or it could be act as better inhibitor for hIMPDH-II.
- Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Aug;32(8):1248-62. doi: 10.1080/07391102.2013.812982. Epub 2013 Jul 8.
- Inosine monophosphate dehydrogenase (IMPDH) enzyme involves in GMP biosynthesis pathway. Type I hIMPDH is expressed at lower levels in all cells, whereas type II is especially observed in acute myelogenous leukemia, chronic myelogenous leukemia cancer cells, and 10 ns simulation of the IMP-NAD(+)
- PMID 23829371
- Fenretinide Induces Ubiquitin-Dependent Proteasomal Degradation of Stearoyl-CoA Desaturase in Human Retinal Pigment Epithelial Cells.
- Samuel W1, Kutty RK, Duncan T, Vijayasarathy C, Kuo BC, Chapa KM, Redmond TM.Author information 1Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland.AbstractStearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids. Increase in SCD expression is strongly implicated in the proliferation and survival of cancer cells, whereas its decrease is known to impair proliferation, induce apoptosis, and restore insulin sensitivity. We examined whether fenretinide, (N-(4-hydroxyphenyl)retinamide, 4HPR), which induces apoptosis in cancer cells and recently shown to improve insulin sensitivity, can modulate the expression of SCD. We observed that fenretinide decreased SCD protein and enzymatic activity in the ARPE-19 human retinal pigment epithelial cell line. Increased expression of BiP/GRP78, ATF4, and GADD153 implicated ER stress. Tunicamycin and thapsigargin, compounds known to induce ER stress, also decreased the SCD protein. This decrease was completely blocked by the proteasome inhibitor MG132. In addition, PYR41, an inhibitor of ubiquitin activating enzyme E1, blocked the fenretinide-mediated decrease in SCD. Immunoprecipitation analysis using anti-ubiquitin and anti-SCD antibodies and the blocking of SCD loss by PYR41 inhibition of ubiquitination further corroborate that fenretinide mediates the degradation of SCD in human RPE cells via the ubiquitin-proteasome dependent pathway. Therefore, the effect of fenretinide on SCD should be considered in its potential therapeutic role against cancer, type-2 diabetes, and retinal diseases. J. Cell. Physiol. 229: 1028-1038, 2014. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
- Journal of cellular physiology.J Cell Physiol.2014 Aug;229(8):1028-38. doi: 10.1002/jcp.24527.
- Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids. Increase in SCD expression is strongly implica
- PMID 24357007
Japanese Journal
- Complementary function of mitogen-activated protein kinase Hog1 from Trichosporonoides megachiliensis in Saccharomyces cerevisiae under hyper-osmotic stress(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Yoshida Junjiro,Kobayashi Yosuke,Tanaka Yosuke,Koyama Yoshiyuki,Ogihara Jun,Kato Jun,Shima Jun,Kasumi Takafumi
- Journal of bioscience and bioengineering 115(2), 127-132, 2013-02-00
- … Functional analyses of chimeric Hog1 proteins constructed from ScHog1 and TmHog1 sequences indicated that the C-terminal region of TmHog1 is more effective for glycerol biosynthesis than ScHog1 under osmotic stress. …
- NAID 110009592559
- オーキシン生合成と今後の展望(<特集>オーキシン研究の新しい展開)
- 笠原 博幸
- 植物の生長調節 47(2), 67-73, 2012-12-20
- … Indole-3-acetic acid (IAA) is the most important naturally occurring auxin, but IAA biosynthesis in plants has been unclear for more than 70 years. … Recently, the main IAA biosynthesis pathway was identified by molecular genetic and biochemical approaches. … This article reviews the recent progress on auxin biosynthesis and its regulation in plants. …
- NAID 110009580311
- Pathway engineering of benzylisoquinoline alkaloid biosynthesis in transgenic California poppy cells with ectopic expression of tetrahydroberberine oxidase from Coptis japonica
- Matsushima Yasutaka,Minami Hiromichi,Hori Kentaro [他]
- Plant Biotechnology 29(5), 473-481, 2012-12-00
- NAID 40019545301
Related Links
- Phenylpropanoid biosynthesis - Reference pathway [ Pathway menu | Organism menu | Pathway entry | Show description | User data mapping] Phenylpropanoids are a group of plant secondary metabolites derived from ...
- Fig. 1. Presumptive pathways for IAA biosynthesis in plants. Green arrows indicate the tryptophan synthetic pathway in the chloroplast. A thin dashed black arrow denotes the tryptophan-independent IAA ...
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★リンクテーブル★
| リンク元 | 「生合成経路」「biosynthetic pathway」 |
| 拡張検索 | 「hexosamine biosynthesis pathway」 |
| 関連記事 | 「biosynthesis」「pathway」 |
「生合成経路」
「biosynthetic pathway」
「hexosamine biosynthesis pathway」
- 関
- HBP
「biosynthesis」
「pathway」
- 関
- route