ヘモグロビン尿症、血色素尿症、ヘモグロビン尿、血色素尿
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/06 16:14:18」(JST)
[Wiki en表示]
Hemoglobinuria |
Structure of hemoglobin
|
Classification and external resources |
ICD-10 |
R82.3 |
ICD-9-CM |
283.2, 791.2 |
DiseasesDB |
19635 |
MeSH |
D006456 |
[edit on Wikidata]
|
In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. The condition is often associated with hemolytic anemia, in which red blood cells (RBCs) are destroyed, thereby increasing levels of free plasma hemoglobin. Excess hemoglobin is filtered by the kidneys, which excrete it into the urine, giving urine a purple color.
Contents
- 1 Causes
- 2 Complications
- 3 Diagnosis
- 4 See also
Causes
- Acute glomerulonephritis
- Burns
- Renal cancer
- Malaria
- Paroxysmal nocturnal hemoglobinuria
- Microangiopathies, e.g. Hemolytic-uremic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP)
- Transfusion reactions
- IgM autoimmune hemolytic anemia
- Pyelonephritis
- Sickle cell anemia
- Tuberculosis of the urinary tract
- March hemoglobinuria secondary to repetitive impacts on the body, usually the feet
- Athletic nephritis secondary to strenuous exercise
- Acute lead poisoning
Complications
Hemoglobinuria can lead to acute tubular necrosis which is an uncommon cause of a death of uni-traumatic patients recovering in the ICU .
Diagnosis
The diagnosis is often made based on the medical history, blood samples, and a urine sample. The absence of urine RBCs and RBC casts microscopically despite a positive dipstick test suggests hemoglobinuria or myoglobinuria. The medical term for RBCs in the urine is hematuria.
See also
‹ The template below (Abnormal clinical and laboratory findings for urine) is being merged. See templates for discussion for the discussion that led to this result. ›
Components and results of urine tests (CPT 81000–81099; R80–R82, 791)
|
|
Components |
- Albumin
- Myoglobin
- hCG
- Leukocyte esterase
- Urine pregnancy test
- Ketone bodies
- Glucose
- Urobilinogen
- Bilirubin
- Creatinine
- RBC
- WBC
- Urinary casts
|
|
Chemical properties |
- Urine specific gravity
- Urine osmolality
- Urine pH
- Urine anion gap
|
|
Abnormal findings |
Red blood cells |
- Hematuria (Microscopic hematuria)
|
|
White blood cells |
|
|
Proteinuria |
- Albuminuria/Microalbuminuria
- Myoglobinuria
- Hemoglobinuria
|
|
Small molecules |
- Glycosuria
- Ketonuria
- Bilirubinuria
- Hyperuricosuria/Hypouricosuria
- Aminoaciduria
|
|
Pathogens |
|
|
Other |
- Chyluria
- Crystalluria
- osmolality (Isosthenuria, Hypersthenuria)
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Paroxysmal nocturnal hemoglobinuria (PNH) and T cell large granular lymphocyte (LGL) leukemia-an unusual association: another cause of cytopenia in PNH.
- Boyer T1, Grardel N, Copin MC, Roumier C, Touzart A, Buchdahl AL, Corm S, Peffault de Latour R, Preudhomme C, Terriou L.
- Annals of hematology.Ann Hematol.2015 Oct;94(10):1759-60. doi: 10.1007/s00277-015-2439-3. Epub 2015 Jul 9.
- PMID 26152552
- Therapeutic drug monitoring of eculizumab: rationale for an individualized dosing schedule.
- Gatault P1, Brachet G, Ternant D, Degenne D, Récipon G, Barbet C, Gyan E, Gouilleux-Gruart V, Bordes C, Farrell A, Halimi JM, Watier H.
- mAbs.MAbs.2015 Sep 4:0. [Epub ahead of print]
- The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic-uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measur
- PMID 26337866
- Balloon-Occluded Retrograde Transvenous Obliteration for the Treatment of Gastric Varices: Polidocanol Foam Versus Liquid Ethanolamine Oleate.
- Itou C1, Koizumi J1, Hashimoto T2, Myojin K3, Kagawa T4, Mine T4, Imai Y1.
- AJR. American journal of roentgenology.AJR Am J Roentgenol.2015 Sep;205(3):659-66. doi: 10.2214/AJR.14.13389.
- OBJECTIVE: The purpose of this study was to evaluate the clinical results of the management of gastric varices by balloon-occluded retrograde transvenous obliteration with polidocanol foam versus ethanolamine oleate.MATERIALS AND METHODS: Twenty patients treated with ethanolamine oleate and 21 patie
- PMID 26295655
Japanese Journal
- Childhood paroxysmal nocturnal haemoglobinuria (PNH), a report of 11 cases in the Netherlands
- Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia
- Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria
Related Links
- haemoglobinuria See hemoglobinuria. he·mo·glo·bi·nu·ri·a (hē'mō-glō'bi-nyūr'ē-ă) The presence of hemoglobin in the urine, including certain closely related pigments formed from slight alteration of the hemoglobin molecule; indicative ...
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating disorder that most frequently presents in early adulthood and usually continuous throughout the life of the patient. PNH results in the death of ...
Related Pictures
![Hemoglobinuria, paroxysmal; Paroxysmal Cold Hemoglobinuria; Paroxysmal Nocturnal](https://1mg.info/0/i/k/2604.jpg)
![Hematuria | eClinpath](https://1mg.info/0/i/u/2194.jpg)
![Disorders of Red Blood Cells - ppt video online download](https://1mg.info/0/i/u/2195.jpg)
![Hemoglobinuria - Cat](https://1mg.info/0/i/u/2196.jpg)
![Investigating jaundice in neonatal foals | Vet Times](https://1mg.info/0/i/u/2197.jpg)