WordNet

send a message from one computer to another to check whether it is reachable and active; "ping your machine in the office"
a sharp high-pitched resonant sound (as of a sonar echo or a bullet striking metal)
contact, usually in order to remind of something; "Ill ping my accountant--April 15 is nearing"
hit with a pinging noise; "The bugs pinged the lamp shade"
make a short high-pitched sound; "the bullet pinged when they struck the car"
the ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...
the 16th letter of the Greek alphabet
any of various enzymes that move a chemical group from one compound to another compound
the 19th letter of the Roman alphabet (同)s

PrepTutorEJDIC

(小銃弾などの)ピュー(ブーン)という音 / ピュー(ブーン)と音がする
〈C〉パイ(ギリシア語アルファベットの第16字Π,π;英語のP,pに相当) / 〈U〉円周率(記号はπ)
ごちゃまぜの活字 / ごちゃまぜ,混乱
sulfurの化学記号 / {略}South[ern]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/18 05:50:08」(JST)

wiki en

Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.^[1]^[2]

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.^[3]

Interactions

GSTP1 has been shown to interact with Fanconi anemia, complementation group C^[4]^[5] and MAPK8.^[6]

References

^ Bora PS, Bora NS, Wu XL, Lange LG (Oct 1991). "Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA". J Biol Chem 266 (25): 16774–7. PMID 1885604.
^ Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (Nov 1995). "Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene". Cytogenet Cell Genet 71 (3): 235–9. doi:10.1159/000134117. PMID 7587384.
^ "Entrez Gene: GSTP1 glutathione S-transferase pi". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2950.
^ Cumming, R C; Lightfoot J, Beard K, Youssoufian H, O'Brien P J, Buchwald M (Jul. 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nat. Med. (United States) 7 (7): 814–20. doi:10.1038/89937. ISSN 1078-8956. PMID 11433346.
^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (Oct. 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622.
^ Wang, T; Arifoglu P, Ronai Z, Tew K D (Jun. 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. (United States) 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. ISSN 0021-9258. PMID 11279197.

UpToDate Contents

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1. 急性尿細管壊死および腎前性疾患の病因および診断 etiology and diagnosis of acute tubular necrosis and prerenal disease
2. 急性腸間膜虚血 acute mesenteric ischemia
3. 腸壁気腫症 pneumatosis intestinalis
4. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
5. 全身性硬化症（強皮症）における消化管疾患の治療 treatment of gastrointestinal disease in systemic sclerosis scleroderma

English Journal

Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: A meta-analysis.

Tang ST, Wang CJ, Tang HQ, Zhang Q, Wang Y.SourceDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gene.Gene.2013 Nov 10;530(2):301-8. doi: 10.1016/j.gene.2013.08.043. Epub 2013 Sep 2.
Genetic polymorphisms of glutathione S-transferases (GSTs) and type 2 diabetes mellitus (T2DM) risk have been widely studied, however, the results were somewhat conflicting. To evaluate the association of GSTs (GSTM1, GSTT1 and GSTP1) gene polymorphisms with T2DM, a meta-analysis was performed befor
PMID 24008019

Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats.

Perdomo VG, Rigalli JP, Villanueva SS, Ruiz ML, Luquita MG, Echenique CG, Catania VA.SourceInstituto de Fisiología Experimental (CONICET)-Area Fisiología, Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), Rosario, Argentina.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Oct;57(10):4894-902. doi: 10.1128/AAC.02531-12. Epub 2013 Jul 22.
The effect of antichagasic benznidazole (BZL; 100 mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransformation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltransferase (UGT1A), glutathione S-transferases (alpha glut
PMID 23877690

Multidrug resistance in primary tumors and metastases in patients with esophageal squamous cell carcinoma.

Qiang F, Guangguo R, Yongtao H, Dandan D, Hong Y.SourceDepartment of Thoracic Surgery, Cancer Hospital of Sichuan Province, No. 55, 4th section of Remin South Rd, Chengdu, 610000, Sichuan province, China, fangqiang111@126.com.
Pathology oncology research : POR.Pathol Oncol Res.2013 Oct;19(4):641-8. doi: 10.1007/s12253-013-9623-3. Epub 2013 Mar 19.
Studies have demonstrated that radical esophagectomy can significantly prolong disease-free survival and improve the survival rate of patients with T3 or T4 esophageal cancer and lymph node metastasis. Multidrug resistant cancer cells have active efflux mechanisms that prevent the accumulation of ch
PMID 23508648

Japanese Journal

Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy.

Kanai Masashi,Yoshioka Akira,Tanaka Shiro,Nagayama Satoshi,Matsumoto Shigemi,Nishimura Takafumi,Niimi Miyuki,Teramukai Satoshi,Takahashi Ryo,Mori Yukiko,Kitano Toshiyuki,Ishiguro Hiroshi,Yanagihara Kazuhiro,Chiba Tsutomu,Fukushima Masanori,Matsuda Fumihiko
Cancer epidemiology 34(2), 189-193, 2010-04
… In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met. …
NAID 120002098847

Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress.

Goto Shinji,Kawakatsu Miho,Izumi Shin-Ichi,Urata Yoshishige,Kageyama Kan,Ihara Yoshito,Koji Takehiko,Kondo Takahito
Free radical biology & medicine 46(10), 1392-1403, 2009-05-15
… Glutathione S-transferases (GSTs) are multifunctional enzymes involved in the protection of cellular components against anti-cancer drugs or peroxidative stress. … Previously we found that GST pi, an isoform of the GSTs, is transported into the nucleus. … In the present study, we found that GST pi is present in mitochondria as well as in the cytosol and nucleus in mammalian cell lines. …
NAID 120001289556

「グルタチオンS-転移酵素π」

Glutathione S-transferase pi 1
	; PDB rendering based on 10gs.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	10GS, 11GS, 12GS, 13GS, 14GS, 16GS, 17GS, 18GS, 19GS, 1AQV, 1AQW, 1AQX, 1EOG, 1EOH, 1GSS, 1KBN, 1LBK, 1MD3, 1MD4, 1PGT, 1PX6, 1PX7, 1ZGN, 20GS, 22GS, 2A2R, 2A2S, 2GSS, 2J9H, 2PGT, 3CSH, 3CSI, 3CSJ, 3DD3, 3DGQ, 3GSS, 3GUS, 3HJM, 3HJO, 3HKR, 3IE3, 3KM6, 3KMN, 3KMO, 3N9J, 3PGT, 4GSS, 4PGT, 5GSS, 6GSS, 7GSS, 8GSS, 9GSS
Identifiers
Symbols	GSTP1; DFN7; FAEES3; GST3; GSTP; PI
External IDs	OMIM: 134660 MGI: 95864 HomoloGene: 660 ChEMBL: 3902 GeneCards: GSTP1 Gene
EC number	2.5.1.18
Gene Ontology
Molecular function	• glutathione transferase activity; • protein binding; • JUN kinase binding; • kinase regulator activity; • S-nitrosoglutathione binding; • dinitrosyl-iron complex binding; • nitric oxide binding;
Cellular component	• intracellular; • nucleus; • cytoplasm; • mitochondrion; • cytosol; • TRAF2-GSTP1 complex;
Biological process	• response to reactive oxygen species; • negative regulation of acute inflammatory response; • negative regulation of protein kinase activity; • glutathione metabolic process; • xenobiotic metabolic process; • anti-apoptosis; • central nervous system development; • negative regulation of biosynthetic process; • negative regulation of tumor necrosis factor-mediated signaling pathway; • negative regulation of interleukin-1 beta production; • negative regulation of tumor necrosis factor production; • regulation of stress-activated MAPK cascade; • negative regulation of stress-activated MAPK cascade; • positive regulation of superoxide anion generation; • common myeloid progenitor cell proliferation; • nitric oxide storage; • negative regulation of apoptotic process; • negative regulation of I-kappaB kinase/NF-kappaB cascade; • negative regulation of MAP kinase activity; • negative regulation of MAPK cascade; • negative regulation of JUN kinase activity; • small molecule metabolic process; • negative regulation of fibroblast proliferation; • negative regulation of nitric-oxide synthase biosynthetic process; • negative regulation of necrotic cell death; • regulation of ERK1 and ERK2 cascade; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of leukocyte proliferation; • cellular response to lipopolysaccharide; • negative regulation of monocyte chemotactic protein-1 production;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: glutathione S-transferase pi
関: グルタチオンS-トランスフェラーゼπ

「グルタチオンS-トランスフェラーゼπ」

　　[★]

英: glutathione S-transferase pi
関: グルタチオンS-転移酵素π

「PI」

　　[★]

肺動脈弁閉鎖不全症 pulmonary insufficiency
ホスファチジルイノシトール phosphatidyl inositol PtdIns
ホスホイノシチド
肺梗塞 pulmonary infarction

「transferase」

　　[★]

n.

トランスフェラーゼ、転移酵素、付加酵素

関: lyase、synthase、transposase

「Pi」

　　[★] オルトリン酸

関: orthophosphate、orthophosphoric acid

「S」

　　[★]

「p」

　　[★]

ピコ

10の-12乗

関: pico

[pmid1885604-1] Bora PS, Bora NS, Wu XL, Lange LG (Oct 1991). "Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA". J Biol Chem 266 (25): 16774–7. PMID 1885604.

[pmid7587384-2] Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (Nov 1995). "Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene". Cytogenet Cell Genet 71 (3): 235–9. doi:10.1159/000134117. PMID 7587384.

[3] "Entrez Gene: GSTP1 glutathione S-transferase pi". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2950.

[pmid11433346-4] Cumming, R C; Lightfoot J, Beard K, Youssoufian H, O'Brien P J, Buchwald M (Jul. 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nat. Med. (United States) 7 (7): 814–20. doi:10.1038/89937. ISSN 1078-8956. PMID 11433346.

[pmid14499622-5] Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (Oct. 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622.

[pmid11279197-6] Wang, T; Arifoglu P, Ronai Z, Tew K D (Jun. 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. (United States) 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. ISSN 0021-9258. PMID 11279197.

リンク元	「グルタチオンS-転移酵素π」「グルタチオンS-トランスフェラーゼπ」
関連記事	「PI」「transferase」「Pi」「S」「p」

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案内

glutathione S-transferase pi