グルコシダーゼ
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/08 22:08:58」(JST)
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Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.
Contents
- 1 Function
- 2 Members
- 3 Clinical significance
- 4 See also
- 5 External links
Function
α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen into their monomers
They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.This enzyme convert complex sugars into the simpler one.
Members
Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.
Name |
EC |
Description |
α-Amylase |
EC 3.2.1.1 |
is a digestive enzyme in mammals |
β-Amylase |
EC 3.2.1.2 |
is a plant enzyme to break down starch |
γ-Amylase |
EC 3.2.1.3 |
is a digestive enzyme |
Cellulase # |
EC 3.2.1.4 |
breaks down cellulose from plant material |
Sucrase-isomaltase |
EC 3.2.1.10 |
- |
Acid α-glucosidase # |
EC 3.2.1.20 |
is associated with Glycogen storage disease type II |
Beta-glucosidase # |
EC 3.2.1.21 |
- is associated with gaucher's disease |
Lactase |
EC 3.2.1.23 |
one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance |
Debranching enzyme # |
EC 3.2.1.33 |
- |
Pullulanase |
EC 3.2.1.41 |
has been used as a detergent |
Clinical significance
They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.
See also
- DNA glycosylases
- Mucopolysaccharidoses
External links
- Glucosidases at the US National Library of Medicine Medical Subject Headings (MeSH)
Hydrolase: sugar hydrolases (EC 3.2)
|
|
3.2.1: Glycoside hydrolases |
Disaccharidase |
- Sucrase/Sucrase-isomaltase/Invertase
- Maltase
- Trehalase
- Lactase
|
|
Glucosidases |
- Cellulase
- Alpha-glucosidase
- Acid
- Neutral AB
- Neutral C
- Beta-glucosidase
- Debranching enzyme
|
|
Other |
- Amylase
- Chitinase
- Lysozyme
- Neuraminidase
- NEU1
- NEU2
- NEU3
- NEU4
- Bacterial neuraminidase
- Viral neuraminidase
- Galactosidases
- alpha-Mannosidase
- Glucuronidase
- Hyaluronidase
- Pullulanase
- Glucosylceramidase
- Galactosylceramidase
- Alpha-N-acetylgalactosaminidase
- Alpha-N-acetylglucosaminidase
- Fucosidase
- Hexosaminidase
- Iduronidase
- Maltase-glucoamylase
- Heparanase
|
|
|
3.2.2: Hydrolysing
N-Glycosyl compounds |
- DNA glycosylases: Oxoguanine glycosylase
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
Proteins: enzymes
|
|
Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
UpToDate Contents
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English Journal
- Phenolics from strawberry cv. Falandi and their antioxidant and α-glucosidase inhibitory activities.
- Yang D1, Xie H2, Jiang Y3, Wei X3.
- Food chemistry.Food Chem.2016 Mar 1;194:857-63. doi: 10.1016/j.foodchem.2015.08.091. Epub 2015 Aug 22.
- Three new phenolic glucosides, falandiosides A (1), B (2), and C (6) were isolated from strawberry (Fragaria×ananassa Duch.) cv. Falandi fruit, together with three flavone glucuronides (3-5), eleven lignan glycosides (12-22), and five others. Their structures were determined by spectroscopic method
- PMID 26471628
- Application of the Kombucha 'tea fungus' for the enhancement of antioxidant and starch hydrolase inhibitory properties of ten herbal teas.
- Watawana MI1, Jayawardena N1, Choo C2, Waisundara VY3.
- Food chemistry.Food Chem.2016 Mar 1;194:304-11. doi: 10.1016/j.foodchem.2015.08.033. Epub 2015 Aug 12.
- Ten herbal teas (Acacia arabica, Aegle marmelos flower, A. marmelos root bark, Aerva lanata, Asteracantha longifolia, Cassia auriculata, Hemidesmus indicus, Hordeum vulgare, Phyllanthus emblica, Tinospora cordifolia) were fermented with the Kombucha 'tea fungus'. The pH values of the fermented bever
- PMID 26471559
- The possible presence of natural β-d-glucosidase inhibitors in jujube leaf extract.
- Jo Y1, Lim S2, Chang PS3, Choi YJ4.
- Food chemistry.Food Chem.2016 Mar 1;194:212-7. doi: 10.1016/j.foodchem.2015.08.007. Epub 2015 Aug 4.
- Isoquercitrin is a phenolic compound well-known for having greater health benefits than quercitin, its aglycone derivative, and other related glycosides. However, isoquercitrin is rarely found in nature. Here, we optimized the conditions for the enzymatic transformation of isoquercitrin from rutin t
- PMID 26471546
Japanese Journal
- 臨床報告 門脈ガス血症を伴うα-グルコシダーゼ阻害薬による腸管囊腫様気腫症の1切除例
- ブラジル産プロポリスのメタボリックシンドローム予防効果
- Inactivation kinetics and conformation change of Hypocrea orientalis β-glucosidase with guanidine hydrochloride
- Journal of bioscience and bioengineering 124(2), 143-149, 2017-08
- NAID 40021295034
Related Links
- オリエンタル酵母工業(株) バイオ事業部の研究用試薬 酵素>β-グルコシダーゼ、アーモンド ... 反応 Hydrolysis of terminal, non-reducing β-D-glucose residues with release of β -D-glucose β -D-Glucoside+H 2 O = Alcohol+β -D ...
- オリエンタル酵母工業(株) バイオ事業部の研究用試薬 酵素>α-グルコシダーゼ、酵母由来 ... 反応 Hydrolysis of terminal, non-reducing 1, 4-linked a-D-glucose residues with release of α-D-glucose α-D-Glucoside+H 2 O = Alcohol+α ...
Related Pictures
![Glucan 1,4-alpha-glucosidase](https://1mg.info/0/f/u/1684.jpg)
![Bêta-glucosidase (Amygdalase; Bêta-D](https://1mg.info/0/b/a/2825.jpg)
![Description Beta glucosidase 3AHX.png](https://1mg.info/0/9/s/0031.jpg)
![glucosidase with an NAD + cofactor](https://1mg.info/0/c/3/0398.jpg)
![of an alpha-glucosidase catalyzed reaction](https://1mg.info/0/f/u/1685.jpg)
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グルコシダーゼ欠損を伴わないリソソームグリコーゲン蓄積病
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βグルコシダーゼ
- 関
- cellulase
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オリゴ-1
- 関
- isomaltase
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α-1,4-グルコシダーゼ
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α-1,4-グルコシダーゼ