グルコセレブロシド
- 関
- glucosylceramide
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/14 07:44:58」(JST)
[Wiki en表示]
Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.
Clinical significance
They occur mostly in nonneuronal tissue and accumulate abnormally in Gaucher disease, where glucocerebrosidase is absent or nonfunctional.
See also
- glucosylceramide synthase
External links
- Glucocerebrosides at the US National Library of Medicine Medical Subject Headings (MeSH)
Glycoconjugates, lipids and glycolipids: sphingolipids and glycosphingolipids, and metabolic intermediates
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Ceramide |
- Cerebroside
- Galactocerebroside
- Glucocerebroside
- Lactosylceramide
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Ganglioside
pathway |
From ganglioside
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From globoside
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From sphingomyelin
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From sulfatide
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To sphingosine
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Other |
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- glycerides
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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English Journal
- Comparative lipidomic study of urothelial cancer models: association with urothelial cancer cell invasiveness.
- Yu Y1, Skočaj M2, Kreft ME3, Resnik N3, Veranič P3, Franceschi P4, Sepčić K5, Guella G6.
- Molecular bioSystems.Mol Biosyst.2016 Aug 16. [Epub ahead of print]
- Comparative lipidomic studies were performed across the RT4 versus T24 urothelial cancer cell lines, as models for noninvasive urothelial papilloma cells (with a relatively high level of differentiation) and invasive urothelial carcinoma cells (with low level of differentiation), respectively. The a
- PMID 27527902
- Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe.
- Belmatoug N1, Di Rocco M2, Fraga C3, Giraldo P4, Hughes D5, Lukina E6, Maison-Blanche P7, Merkel M8, Niederau C9, Plӧckinger U10, Richter J11, Stulnig TM12, Vom Dahl S13, Cox TM14.
- European journal of internal medicine.Eur J Intern Med.2016 Aug 10. pii: S0953-6205(16)30217-5. doi: 10.1016/j.ejim.2016.07.011. [Epub ahead of print]
- PURPOSE: In Gaucher disease, diminished activity of the lysosomal enzyme, acid β-glucosidase, leads to accumulation of glucosylceramides and related substrates, primarily in the spleen, liver, and bone marrow. Eliglustat is an oral substrate reduction therapy approved in the European Union and the
- PMID 27522145
- An LC/MS/MS method for the simultaneous determination of individual sphingolipid species in B cells.
- Mi S1, Zhao YY1, Dielschneider RF2, Gibson SB2, Curtis JM3.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2016 Jul 16;1031:50-60. doi: 10.1016/j.jchromb.2016.07.028. [Epub ahead of print]
- Comprehensive profiling of sphingolipids is of great importance for clinical and pharmaceutical studies. An LC/MS/MS method was established for the simultaneous separation and quantification of individual sphingolipid species including ceramides, dihydroceramides, glucosylceramides, sphingosine, sph
- PMID 27450899
Japanese Journal
- Isolation and Structure of a Galactocerebroside from the Sea Cucumber Bohadschia argus
- Ikeda Yuriko,Inagaki Masanori,Yamada Koji [他],ZHANG Xiao Wen,ZHANG Bo,MIYAMOTO Tomofumi,HIGUCHI Ryuichi
- Chemical & pharmaceutical bulletin 57(3), 315-317, 2009-03-01
- … The parent cerebroside BAC-4 has been isolated from less polar lipid fraction of CHCl_3/MeOH extract of sea cucumber Bohadschia argus, together with known typical types of glucocerebroside molecular species. …
- NAID 110007122349
- 串田 吉生,羽場 礼次,門田 球一,香月奈 穂美,宮井 由美,坂東 健次,佐々木 真紀子,河野 良太,川口 洋治,山本 哲司
- 診断病理 : Japanese journal of diagnostic pathology 25(2), 97-99, 2008-04-30
- NAID 10021252103
- スジエビPalaemon Paucidensのセレブロシド
- 糸乗 前,鵜飼 佑輝,井上 多加志 [他],小島 寿夫,齋藤 洋昭,伊藤 將弘,杉田 睦海
- 滋賀大学教育学部紀要. 3, 自然科学 58, 13-20, 2008
- … The purified cerebroside (6.5mg) was characterized to be a glucocerebroside by gas-liquid chromatography (GC), gas chromatograph-mass spectrometry (GC-MS), matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 1H-nuclear magnetic resonance spectroscopy (NMR). …
- NAID 110007092951
Related Links
- What Kind Of Functional Groups Are In Glucocerebroside? Dictionary.com Word FAQs Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries. Differences ...
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Related Pictures
★リンクテーブル★
[★]
- 英
- glucocerebroside
- 同
- グルコシルセラミド、glucosylceramide
- 関
- グルコセレブロシダーゼ、セレブロシド
- セラミドの1位の水酸基にグルコースがβ-グリコシド結合した構造のスフィンゴ糖脂質で,細胞膜微量構成成分
臨床関連
- グルコセレブロシドのグリコシド結合を加水分解するリソソーム酵素(グルコセレブロシダーゼ)の遺伝的に欠損により生じる
[★]
グルコシルセラミド
- 関
- glucocerebroside