germline mutation

• 生殖細胞系列変異

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germ-line mutation

WordNet

1. (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism (同)genetic mutation, chromosomal_mutation
2. a change or alteration in form or qualities

PrepTutorEJDIC

1. 変化,俸転 / (生物の)突然変異;その変種

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/25 10:59:53」(JST)

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[Wiki en表示]

A germline mutation is any detectable and heritable variation in the lineage of germ cells. Mutations in these cells are transmitted to offspring, while, on the other hand, those in somatic cells are not. A germline mutation gives rise to a constitutional mutation in the offspring, that is, a mutation that is present in virtually every cell. A constitutional mutation can also occur very soon after fertilisation, or continue from a previous constitutional mutation in a parent.

This distinction is most important in animals, where germ cells are distinct from somatic cells. However, in plants, the reproductive cells in a particular flower will be derived from the same meristem as the cells in that flower and on the stem leading to the flower, which is a different population of cells than those that give rise to the other flowers on the plant. Single-celled organisms have no distinction between germline and somatic tissues.

In animals, mutations are more likely to occur in sperm than in ova, because a larger number of cell divisions are involved in the production of sperm.

Mutations that are not germline are somatic mutations, which are also called acquired mutations.

See also

• Germline
• Mutation

References

UpToDate Contents

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English Journal

• A mutation in POLE predisposing to a multi-tumour phenotype.

• Rohlin A1, Zagoras T1, Nilsson S2, Lundstam U3, Wahlström J1, Hultén L4, Martinsson T1, Karlsson GB5, Nordling M1.
• International journal of oncology.Int J Oncol.2014 Jul;45(1):77-81. doi: 10.3892/ijo.2014.2410. Epub 2014 Apr 29.
• Somatic mutations in the POLE gene encoding the catalytic subunit of DNA polymerase ε have been found in sporadic colorectal cancers (CRCs) and are most likely of importance in tumour development and/or progression. Recently, families with dominantly inherited colorectal adenomas and colorectal ca
• PMID 24788313

• Pyloric gland adenoma in lynch syndrome.

• Lee SE1, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM.
• The American journal of surgical pathology.Am J Surg Pathol.2014 Jun;38(6):784-92. doi: 10.1097/PAS.0000000000000185.
• The prevalence of gastric cancer associated with Lynch syndrome (LS) is highly variable, and the underlying histologic pathway or molecular mechanisms remain unclear. From 1995 to 2012, 15 patients had been treated for both gastric and colonic adenocarcinomas and diagnosed as LS. In all cases, patho
• PMID 24518125

• Intratumoral peripheral small papillary tufts: a diagnostic clue of renal tumors associated with Birt-Hogg-Dubé syndrome.

• Kuroda N1, Furuya M2, Nagashima Y2, Gotohda H3, Moritani S4, Kawakami F5, Imamura Y6, Bando Y7, Takahashi M8, Kanayama HO8, Ota S9, Michal M10, Hes O10, Nakatani Y9.
• Annals of diagnostic pathology.Ann Diagn Pathol.2014 Jun;18(3):171-6. doi: 10.1016/j.anndiagpath.2014.03.002. Epub 2014 Mar 29.
• In this article, we searched for the common histologic characteristic of renal tumors in patients with Birt-Hogg-Dubé syndrome (BHDS). We selected 6 patients with histologically confirmed renal tumor in BHDS. Germline FLCN gene mutation has been identified in 5 patients. Multifocality and bilateral
• PMID 24767893

Japanese Journal

• 大腸癌を合併しSMAD4遺伝子異常を確認できた若年性ポリポーシスの1例

• 三宅 清花,上田 渉,有本 雄貴,佐野 弘治,大川 清孝,田村 和朗
• 日本大腸肛門病学会雑誌 64(3), 170-177, 2011-03-01
• 症例は40歳代男性．食欲不振と下腿浮腫を自覚し近医を受診した．貧血と低蛋白血症を認め精査のため入院となった．上部消化管内視鏡検査で胃にポリープが密生し胃ポリポーシスと診断した．下部消化管内視鏡検査では盲腸には2型腫瘍と周囲に数個のポリープが見られた．直腸には数十個のポリープを認めた．胃ポリープの生検組織像，十二指腸ポリープと直腸ポリープの内視鏡的粘膜切除の組織像から若年性ポリポーシスと診断できたが …
• NAID 10029095209

• P-062 DNAポリメラーゼδ変異マウスを利用した高い生殖系列突然変異率が後世代に及ぼす影響の解析(ポスターセッション)

• 内村 有邦,日高 裕子,増村 健一,能美 健彦,三浦 郁生,若菜 茂晴,八木 健
• 日本環境変異原学会大会プログラム・要旨集 (39), 123, 2010-10-29
• NAID 110008512847

Related Links

• somatic vs germline 15 - zohiducha.ebb.jp

Hi,. Let＆#39;s say that I get whole-exome-sequencing data file that has been created without the availability of a normal sample related to the tumor sample sequenced. Is there a way to make the disctinction bewteen germline and ...

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論文：A novel pathogenic germline mutation in the adenom...[Oncotarget] - Pubmed Result(ATGCchecker)の詳細情報です。フルテキスト情報、関連する論文情報も掲載。 こんにちは。ログインしてください。初めての方は会員登録 ...

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リンク元	「germ-line mutation」「生殖細胞系列変異」
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「germ-line mutation」

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• 生殖細胞系列変異

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germline mutation

「生殖細胞系列変異」

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英

germline mutation、germ-line mutation

「germline」

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• 生殖系列

関

germ cell line、germ line