gamma-glutamyl hydrolase

γグルタミルヒドロラーゼ

関

conjugase

WordNet

1. a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
2. the 3rd letter of the Greek alphabet
3. a herd of whales

PrepTutorEJDIC

1. ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
2. (特に女性の)魅力的な脚,すんなりした脚

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/19 04:29:24」(JST)

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Gamma-glutamyl hydrolase
Identifiers
EC number	3.4.19.9
CAS number	9074-87-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
PDB rendering based on 1l9x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1L9X
Identifiers
Symbols	GGH ; GH
External IDs	OMIM: 601509 MGI: 1329035 HomoloGene: 2881 IUPHAR: 2367 ChEMBL: 2223 GeneCards: GGH Gene
EC number	3.4.19.9
Gene ontology Molecular function • exopeptidase activity • omega peptidase activity • gamma-glutamyl-peptidase activity Cellular component • extracellular space • nucleus • lysosome • cytosol • melanosome • extracellular vesicular exosome Biological process • proteolysis • glutamine metabolic process • response to zinc ion • response to insulin • response to drug • response to ethanol Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8836	14590
Ensembl	ENSG00000137563	ENSMUSG00000073987
UniProt	Q92820	Q9Z0L8
RefSeq (mRNA)	NM_003878	NM_010281
RefSeq (protein)	NP_003869	NP_034411
Location (UCSC)	Chr 8: 63.93 – 63.95 Mb	Chr 4: 20.04 – 20.07 Mb
PubMed search	[1]	[2]

Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.

Nomenclature

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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File:FluoropyrimidineActivity_WP1601.png

Fluorouracil (5-FU) Activity edit

References

Further reading

• Galivan J, Ryan T, Rhee M et al. (1999). "Glutamyl hydrolase: properties and pharmacologic impact". Semin. Oncol. 26 (2 Suppl 6): 33–7. PMID 10598552.  CS1 maint: Explicit use of et al. (link)
• O'Connor BM, Rotundo RF, Nimec Z et al. (1991). "Secretion of gamma-glutamyl hydrolase in vitro". Cancer Res. 51 (15): 3874–81. PMID 1713122.  CS1 maint: Explicit use of et al. (link)
• Chandler CJ, Wang TT, Halsted CH (1986). "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization". J. Biol. Chem. 261 (2): 928–33. PMID 2867095. 
• Wang TT, Chandler CJ, Halsted CH (1986). "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization". J. Biol. Chem. 261 (29): 13551–5. PMID 3759978. 
• Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. doi:10.1074/jbc.271.15.8525. PMID 8621474. 
• Rhee MS, Lindau-Shepard B, Chave KJ et al. (1998). "Characterization of human cellular gamma-glutamyl hydrolase". Mol. Pharmacol. 53 (6): 1040–6. PMID 9614206.  CS1 maint: Explicit use of et al. (link)
• Li H, Ryan TJ, Chave KJ, Van Roey P (2002). "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate". J. Biol. Chem. 277 (27): 24522–9. doi:10.1074/jbc.M202020200. PMID 11953431. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Basrur V, Yang F, Kushimoto T et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• He P, Varticovski L, Bowman ED et al. (2004). "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray". Hum. Pathol. 35 (10): 1196–209. doi:10.1016/j.humpath.2004.06.014. PMID 15492986.  CS1 maint: Explicit use of et al. (link)
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  CS1 maint: Explicit use of et al. (link)
• Eisele LE, Chave KJ, Lehning AC, Ryan TJ (2006). "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer". Biochim. Biophys. Acta 1764 (9): 1479–86. doi:10.1016/j.bbapap.2006.06.008. PMID 16945597. 
• Chi A, Valencia JC, Hu ZZ et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.  CS1 maint: Explicit use of et al. (link)
• Hayashi H, Fujimaki C, Inoue K et al. (2007). "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population". Biol. Pharm. Bull. 30 (4): 839–41. doi:10.1248/bpb.30.839. PMID 17409534.  CS1 maint: Explicit use of et al. (link)

External links

• Gamma-glutamyl hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く） disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency
• 2. ビタミンKおよびその合成ならびにガンマカルボキシグルタミン酸の機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
• 3. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-グルタミルトランスペプチダーゼなど） enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase
• 4. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
• 5. 肝脾T細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of hepatosplenic t cell lymphoma

English Journal

• Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes.

• Wani NA, Hamid A, Kaur J.SourceDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
• Molecular and cellular biochemistry.Mol Cell Biochem.2012 Apr;363(1-2):157-66. Epub 2011 Dec 7.
• Folate plays a critical role in maintaining normal metabolic, energy, differentiation and growth status of all mammalian cells. The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-gluta
• PMID 22147198

• Glucarpidase (Voraxaze) for methotrexate toxicity.

• [No authors listed]
• The Medical letter on drugs and therapeutics.Med Lett Drugs Ther.2012 Mar 5;54(1385):19-20.
• PMID 22382581

Japanese Journal

• Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity

• SAKAMOTO E
• Biochem Biophys Res Commun 365, 801-807, 2008
• NAID 80018043816

• High Throughput Quantitative Glycomics and Glycoform-focused Proteomics of Murine Dermis and Epidermis

• Uematsu Rie,Furukawa Jun-ichi,Nakagawa Hiroaki,Shinohara Yasuro,Deguchi Kisaburo,Monde Kenji,Nishimura Shin-Ichiro
• Molecular & Cellular Proteomics 4(12), 1977-1989, 2005-09-16
• … Glycoproteins identified were often contained in lysosomes (e.g. cathepsin L and gamma-glutamyl hydrolase), lamellar granules (e.g. glucosylceramidase and cathepsin D), and desmosomes (e g. …
• NAID 120000957712

• Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray

• HE P
• Hum Pathol. 35, 1196-1209, 2004
• NAID 30015169518

Related Links

• gamma-glutamyl hydrolase - Definition - Mondofacto

gamma-glutamyl hydrolase definition from the mondofacto online medical dictionary ... help contact sitemap gamma-glutamyl hydrolase definition home dictionary word tools courses study skills forum about us Search dictionary help

• gamma-glutamyl hydrolase - definition of gamma-glutamyl ...

GGH A gene on chromosome 8q12.3 that encodes gamma-glutamyl hydrolase, which progressively removes gamma-glutamyl residues from pteroyl poly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free ...

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★リンクテーブル★

リンク元	「γグルタミルヒドロラーゼ」「γ-グルタミルヒドロラーゼ」「conjugase」
関連記事	「hydrolase」「hydrolases」「gamma」

「γグルタミルヒドロラーゼ」

　　[★]

英

gamma-glutamyl hydrolase

関

コンジュガーゼ、γ-グルタミルヒドロラーゼ

「γ-グルタミルヒドロラーゼ」

　　[★]

英

gamma-glutamyl hydrolase

関

γグルタミルヒドロラーゼ

「conjugase」

　　[★]

コンジュガーゼ

関

gamma-glutamyl hydrolase

「hydrolase」

　　[★]

• n.

• ヒドロラーゼ、加水分解酵素

「hydrolases」

　　[★]

• n.

• ヒドロラーゼ、加水分解酵素

「gamma」

　　[★] γ ガンマ