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a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
least expensive statin drug (trade name Lescol); usually taken orally at bedtime (同)Lescol

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/10 09:37:43」(JST)

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Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.^[1]

References[edit]

^ Bader T, Fazili J, Madhoun M, et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383–9. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471.

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1. 周術期の投薬マネージメント perioperative medication management
2. スタチン：作用、副作用、および投与 statins actions side effects and administration
3. スタチン誘発性ミオパチー statin myopathy
4. 腎移植後の脂質異常 lipid abnormalities after renal transplantation
5. スタチンと慢性腎臓病 statins and chronic kidney disease

English Journal

Statin use and the risk of Clostridium difficile in academic medical centres.

Motzkus-Feagans CA, Pakyz A, Polk R, Gambassi G, Lapane KL.SourceDepartment of Epidemiology and Community Health, Virginia Commonwealth University, School of Medicine, 830 E. Main Street, RM 5010, P.O. Box 980212, Richmond, VA 23298-0212, USA; motzkusca@vcu.edu.
Gut.Gut.2012 Nov;61(11):1538-42. Epub 2012 Mar 22.
OBJECTIVES: To estimate the possible relationship between statin use and the risk of healthcare facility onset Clostridium difficile.METHODS: Patients over 18 years of age admitted to hospitals contributing data to the University HealthSystem Consortium between 2002 and 2009 were eligible. Patients
PMID 22442166

Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells.

Mrad MF, Mouawad CA, Al-Hariri M, Eid AA, Alam J, Habib A.SourceDepartment of Biochemistry and Molecular Genetics, American University of Beirut, POBox 11-236, Lebanon.
Journal of cellular biochemistry.J Cell Biochem.2012 Nov;113(11):3466-75. doi: 10.1002/jcb.24223.
Statins, inhibitors of HMG CoA reductase, have pleiotropic effects independent of their capacity to lower cholesterol. Heme-oxygenase-1(HO-1) plays an important role as an anti-oxidant and anti-inflammatory enzyme. In the present study, we used NIH 3T3 cells which express HO-1 to investigate the mol
PMID 22689023

Japanese Journal

市販薬およびフルバスタチンナトリウムによる薬物性肝障害を発症した Gilbert 症候群の1例

綾田穣,石川哲也,奥村明彦,堀田直樹,広瀬昭憲,増子和郎,各務伸一
肝臓 50(3), 139-144, 2009-03-25
症例は，56歳女性．心窩部痛と嘔吐に対し市販薬を内服するも改善せず，外来を受診．黄疸，肝胆道系酵素の上昇を認めたため入院となった．市販薬による薬物性肝障害を疑い，内服を中止．肝障害は軽快した．退院後，高脂血症に対しフルバスタチンナトリウムを投与したところ再び肝障害が出現した．内服中止により，肝障害は改善したが，以後も持続する間接ビリルビン優位の高ビリルビン血症を認めた．Gilbert症候群を疑い， …
NAID 10024804922

フルバスタチンによる肝障害の1例

和智恵子,石井耕司,池原孝,篠原正夫,川船隆史,住野泰清,野中博子
東邦醫學會雜誌 = Journal of the Medical Society of Toho University 48(2), 153-158, 2001-03-01
NAID 10012206486

「フルバスタチン」

Fluvastatin
Systematic (IUPAC) name
	(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Clinical data
Trade names	Lescol
AHFS/Drugs.com	monograph
MedlinePlus	a694010
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Protein binding	98%
Half-life	2.5 hours
Identifiers
CAS number	93957-54-1
ATC code	C10AA04
PubChem	CID 446155
DrugBank	DB01095
ChemSpider	393587
UNII	4L066368AS
KEGG	D07983
ChEBI	CHEBI:38565
ChEMBL	CHEMBL1078
Chemical data
Formula	C24H26FNO4
Mol. mass	411.466 g/mol
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3;
	InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 ; Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N ;
(what is this?) (verify);

　　[★]

英: fluvastatin、
化: フルバスタチンナトリウム fluvastatin sodium
商: ローコール

[1] Bader T, Fazili J, Madhoun M, et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383–9. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471.

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fluvastatin sodium