WordNet

preservation and methodical arrangement as of documents and papers etc.; "I have some filing to do"
the act of using a file (as in shaping or smoothing an object)
a fragment rubbed off by the use of a file
the entering of a legal document into the public record; "he filed a complaint"; "he filed his tax return"

PrepTutorEJDIC

とじ込み,書類整理
〈U〉やすり仕上げ,やすりかけ / 《復数形で》やすりくず

English Journal

Novel systems for tailored neurotrophic factor release based on hydrogel and resorbable glass hollow fibers.

Novajra G1, Tonda-Turo C2, Vitale-Brovarone C3, Ciardelli G2, Geuna S4, Raimondo S4.Author information 1Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy; Department of Clinical and Biological Sciences and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Torino, Italy.2Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.3Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address: chiara.vitale@polito.it.4Department of Clinical and Biological Sciences and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Torino, Italy.AbstractA novel system for the release of neurotrophic factor into a nerve guidance channel (NGC) based on resorbable phosphate glass hollow fibers (50P2O5-30CaO-9Na2O-3SiO2-3MgO-2.5K2O-2.5TiO2 mol%) in combination with a genipin-crosslinked agar/gelatin hydrogel (A/G_GP) is proposed. No negative effect on the growth of neonatal olfactory bulb ensheathing cell line (NOBEC) as well as on the expression of pro- and anti-apoptotic proteins was measured in vitro in the presence of fiber dissolution products in the culture medium. For the release studies, fluorescein isothiocyanate-dextran (FD-20), taken as growth factor model molecule, was solubilized in different media and introduced into the fiber lumen exploiting the capillary action. The fibers were filled with i) FD-20/phosphate buffered saline (PBS) solution, ii) FD-20/hydrogel solution before gelation and iii) hydrogel before gelation, subsequently lyophilized and then filled with the FD-20/PBS solution. The different strategies used for the loading of the FD-20 into the fibers resulted in different release kinetics. A slower release was observed with the use of A/G_GP hydrogel. At last, poly(ε-caprolactone) (PCL) nerve guides containing the hollow fibers and the hydrogel have been fabricated.
Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2014 Mar 1;36:25-32. doi: 10.1016/j.msec.2013.11.035. Epub 2013 Dec 4.
A novel system for the release of neurotrophic factor into a nerve guidance channel (NGC) based on resorbable phosphate glass hollow fibers (50P2O5-30CaO-9Na2O-3SiO2-3MgO-2.5K2O-2.5TiO2 mol%) in combination with a genipin-crosslinked agar/gelatin hydrogel (A/G_GP) is proposed. No negative effect on
PMID 24433883

Olfactory experience modulates immature neuron development in postnatal and adult guinea pig piriform cortex.

He X1, Zhang XM2, Wu J2, Fu J2, Mou L3, Lu DH1, Cai Y1, Luo XG1, Pan A1, Yan XX4.Author information 1Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China.2Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.3Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China; Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.4Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China. Electronic address: yanxiaoxin@csu.edu.cn.AbstractImmature neurons expressing doublecortin (DCX+) are present around cortical layer II in various mammals including guinea pigs and humans, especially enriched in the paleocortex. However, little is known whether and how functional experience affects the development of this population of neurons. We attempted to explore a modulation by experience to layer II DCX+ cells in the primary olfactory cortex in postnatal and adult guinea pigs. Neonatal and 1-year-old guinea pigs were subjected to unilateral naris-occlusion, followed 1 and 2months later by morphometry of DCX+ cells in the piriform cortex. DCX+ somata and processes were reduced in the deprived relative to the non-deprived piriform cortex in both age groups at the two surviving time points. The number of DCX+ cells was decreased in the deprived side relative to internal control at 1 and 2months in the youths and at 2months in the adults post-occlusion. The mean somal area of DCX+ cells showed a trend of decrease in the deprived side relative to the internal control in the youths. In addition, DCX+ cells in the deprived side exhibited a lower frequency of colocalization with the neuron-specific nuclear antigen (NeuN) relative to counterparts. These results suggest that normal olfactory experience is required for the maintenance and development of DCX+ immature neurons in postnatal and adult guinea pig piriform cortex.
Neuroscience.Neuroscience.2014 Feb 14;259:101-12. doi: 10.1016/j.neuroscience.2013.11.056. Epub 2013 Dec 4.
Immature neurons expressing doublecortin (DCX+) are present around cortical layer II in various mammals including guinea pigs and humans, especially enriched in the paleocortex. However, little is known whether and how functional experience affects the development of this population of neurons. We a
PMID 24316472

A synthetic oxygen carrier-olfactory ensheathing cell composition system for the promotion of sciatic nerve regeneration.

Zhu S1, Ge J1, Wang Y2, Qi F3, Ma T1, Wang M4, Yang Y1, Liu Z1, Huang J5, Luo Z6.Author information 1Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.2Institute of Orthopaedics, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, China.3Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command of Chinese PLA, Wuhan, Hubei 430070, China.4General Political Department Hospital of PLA, Beijing 100120, China.5Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address: huangjh@fmmu.edu.cn.6Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address: zjluo@fmmu.edu.cn.AbstractThe treatment of lengthy peripheral nerve defects is challenging in the field of the regenerative medicine. Thus far, many nerve scaffolds with seeded cells have been developed, which hold great potential to replace nerve autograft in bridging lengthy nerve defects by providing guiding and bioactive cues. However, low oxygen status has been found within nerve scaffolds after their implantation in vivo, which has been shown to result in death or loss of function of supportive cells, and significantly limit nerve regeneration and functional recovery after nerve injury. In the present study, perfluorotributylamine (PFTBA) was introduced into a collagen-chitosan conduit within which olfactory ensheathing cells (OECs) were seeded to increase oxygen supply to OECs, as well as regenerating axons. The "PFTBA-OECs" enriched scaffolds were then used to bridge a 15-mm-long sciatic nerve defect in rats. Both nerve regeneration and functional recovery were examined at pre-defined time points after surgery. We found that the number of GFP-labeled OECs was significantly higher in the "PFTBA-OECs" scaffold than that in the single OECs scaffold. In addition, PFTBA was found to enhance the beneficial effect of OECs-enriched scaffold on axonal regeneration and functional recovery. All these findings indicate that the "PFTBA-OECs" enriched scaffolds are capable of promoting nerve regeneration and functional recovery, which might be attributable, at least in part, to their beneficial effect on the survival of OECs after their implantation in vivo.
Biomaterials.Biomaterials.2014 Feb;35(5):1450-61. doi: 10.1016/j.biomaterials.2013.10.071. Epub 2013 Nov 15.
The treatment of lengthy peripheral nerve defects is challenging in the field of the regenerative medicine. Thus far, many nerve scaffolds with seeded cells have been developed, which hold great potential to replace nerve autograft in bridging lengthy nerve defects by providing guiding and bioactive
PMID 24246645

Japanese Journal

Two Cases of Subfrontal Schwannoma, Including a Rare Case Located between the Endosteal and Meningeal Layers of the Dura

OKAMOTO Hiroaki,MINETA Toshihiro,WAKAMIYA Tomihiro,TSUKAMOTO Haruhisa,KATSUTA Toshiro,NAKAGAKI Hiroyuki,MATSUSHIMA Toshio
Neurologia medico-chirurgica, 2013
… This rare case suggests that subfrontal schwannomas may originate from the fila olfactoria. …
NAID 130003383280

Olfactory Groove Schwannoma : Case Report

MURAKAMI Mamoru,TSUKAHARA Tetsuya,HATANO Taketo,NAKAKUKI Takuya,OGINO Eiji,AOYAMA Takako
Neurologia medico-chirurgica 44(4), 191-194, 2004-04-15
… The precise origin of these tumors is not well understood, but the tumor in this case probably arose from the fila olfactoria, because the olfactory bulb was involved in the tumor, whereas the olfactory tract remained intact. …
NAID 110002277196

異臭症の臨床的検討

木村恭之,三輪高喜,坂下英雄,土定建夫,石丸正,古川仭
日本耳鼻咽喉科学会会報 95(1), 51-57, 1992
… Post-traumatic olfactory disturbance is caused by transection of the fila olfactoria, which is part of an olfactory neuron, while post-inflammatory olfactory disturbance is caused by damage to olfactory receptor cells. …
NAID 130000805647