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1. アポトーシスと自己免疫疾患apoptosis and autoimmune disease [show details]
…prevents cell death and as egl-1 promotes cell death (by preventing the function of ced-9) . In higher eukaryotes, the core death program can be triggered from without (external or extrinsic) or from within …
2. 軟骨肉腫chondrosarcoma [show details]
…human Apo2L/TRAIL , and a fully human IgG1 monoclonal antibody that triggers the extrinsic apoptosis pathway through death receptor 5 . Finally, mutations in isocitrate dehydrogenase-1 and isocitrate dehydrogenase…
3. 脳死の診断diagnosis of brain death [show details]
… other potential brain death mimics (eg, metabolic encephalopathy) may produce a neurologic examination consistent with brain death, but they should not be mistaken for brain death if the other criteria …
4. 過敏性肺炎（外因性アレルギー性肺胞炎）：治療、予後、予防hypersensitivity pneumonitis extrinsic allergic alveolitis treatment prognosis and prevention [show details]
… Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a syndrome characterized by diffuse inflammation of lung parenchyma and airways in response to the inhalation of antigens … and also frequency of acute exacerbations or death did not meet significance.…
5. SIDSを含む乳児の予期せぬ死亡：初期マネージメントsudden unexpected infant death including sids initial management [show details]
… sleep-related infant deaths are discussed separately. Sudden unexpected infant deaths (SUIDs) can be subdivided into explained SUID and unexplained SUID: Unexplained SUID includes those deaths considered to …

English Journal

Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway.

Wang F, Ye X, Zhai D, Dai W, Wu Y, Chen J, Chen W.
Acta pharmaceutica (Zagreb, Croatia). 2020 Jun;70(2)227-237.
Curcumin is a lipophilic anti-cancer compound extracted from turmeric. Our previous study demonstrated that the curcumin-loaded nanostructured lipid carrier (Cur-NLC) exhibits superior anti-cancer activity in inhibiting proliferation as well as inducing apoptosis of human HepG2 cells compared to nat
PMID 31955141

Biotechnological approach to induce human fibroblast apoptosis using superparamagnetic iron oxide nanoparticles.

Ferraz FS, López JL, Lacerda SMSN, Procópio MS, Figueiredo AFA, Martins EMN, Guimarães PPG, Ladeira LO, Kitten GT, Dias FF, Domingues RZ, Costa GMJ.
Journal of inorganic biochemistry. 2020 May;206()111017.
Cancer-Associated Fibroblasts (CAFs) contribute to tumour progression and have received significant attention as a therapeutic target. These cells produce growth factors, cytokines and chemokines, stimulating cancer cell proliferation and inhibiting their apoptosis. Recent advances in drug delivery
PMID 32120160

hsa-miR-766-5p as a new regulator of mitochondrial apoptosis pathway for discriminating of cell death from cardiac differentiation.

Dokanehiifard S, Soltani BM, Ghiasi P, Baharvand H, Reza Ganjali M, Hosseinkhani S.
Gene. 2020 Apr;736()144448.
Dispose of unnecessary cells in multicellular organism take place through apoptosis as a mode of programmed cell death (PCD). This process is triggered through two main pathway including extrinsic pathway or death receptor pathway and intrinsic or mitochondrial pathway. An alternative role for mitoc
PMID 32032743

Japanese Journal

Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway

Kim Sung Ok,Jin Cheng-Yun,Hwang Eun-Joo,Choi Yung Hyun,Cha Hee-Jae,Park Cheol,Lee Hyesook,Hong Su Hyun,Jeong Soon-Jeong,Park Shin-Hyung,Kim Gi-Young,Leem Sun-Hee
BioScience Trends 13(4), 324-333, 2019
… Cordycepin activated caspase-8 and -9, which are involved in the initiation of extrinsic and intrinsic apoptosis pathways, respectively, and also increased caspase-3 activity, a typical effect caspase, subsequently leading to poly (ADP-ribose) polymerase cleavage. … Furthermore, the presence of NAC significantly attenuated the enhanced apoptotic cell death and reduction of cell viability by treatment with cordycepin and LY294002. …
NAID 130007708724

Induction of Apoptosis by <i>Citrus unshiu</i> Peel in Human Breast Cancer MCF-7 Cells: Involvement of ROS-Dependent Activation of AMPK

Kim Min Yeong,Bo Hyun Hwang,Choi Eun Ok,Kwon Da He,Kim Hong Jae,Ahn Kyu Im,Ji Seon Yeong,Jeong Jin-Woo,Park Shin-Hyung,Hong Su-Hyun,Kim Gi-Young,Park Cheol,Kim Heui-Soo,Moon Sung-Kwon,Yun Seok-Joong,Kim Wun Jae,Choi Yung Hyun
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 41(5), 713-721, 2018
… WECU-induced apoptotic cell death was related to the activation of caspase-8 and -9, representative initiate caspases of extrinsic and intrinsic apoptosis pathways, respectively, and increase in the Bax : Bcl-2 ratio accompanied by cleavage of poly(ADP-ribose) polymerase (PARP). … Therefore, our data indicate that WECU suppresses MCF-7 cell proliferation by activating the intrinsic and extrinsic apoptosis pathways through ROS-dependent AMPK pathway activation.</p> …
NAID 130006730711

Functional conservation of the apoptotic machinery from coral to man: The diverse and complex Bcl-2 and caspase repertoires of Acropora millepora

Moya Aurelie,Sakamaki Kazuhiro,Mason Benjamin M.,Huisman Lotte,Forêt Sylvain,Weiss Yvonne,Bull Tara E.,Tomii Kentaro,Imai Kenichiro,Hayward David C.,Ball Eldon E.,Miller David J.
BMC Genomics (17), 2016-01-16
… Background: Apoptotic cell death is a defining and ubiquitous characteristic of metazoans, but its evolutionary origins are unclear. … Although Caenorhabditis and Drosophila played key roles in establishing the molecular bases of apoptosis, it is now clear that cell death pathways of these animals do not reflect ancestral characteristics. …
NAID 120005758259