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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/23 22:31:35」(JST)

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Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors.^[1] However, in vitro studies indicate that etilefrine has a much higher affinity for β₁ (cardiac) than for β₂ adrenoreceptors.^[2]

Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1–8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β₁ and α₁ adrenergic effects in man.

References

^ Nusser, Donath and Russ, 1965; Mellander, 1966; Limbourg, Just and Lang, 1973; Tarnow et al.~1973; Carrera and Aguilera, 1973.
^ Offermeier and Dreyer, 1971.

External links

PubChem: Etilefrine
Kegg: Etilefrine

UpToDate Contents

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1. 鎌状赤血球症における持続勃起症の診断およびマネージメント diagnosis and management of priapism in sickle cell disease
2. 成人の反射性失神：治療 reflex syncope in adults treatment

English Journal

The changing management of chylothorax in the modern era.

Bender B1, Murthy V2, Chamberlain RS3.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.Eur J Cardiothorac Surg.2016 Jan;49(1):18-24. doi: 10.1093/ejcts/ezv041. Epub 2015 Mar 1.
Initial conservative therapy is applied to all cases of chylothorax (CTx) with expected excellent outcomes. The indication for aggressive surgical treatment of early CTx remains uncertain and requires rigorous scientific scrutiny. Lymphangiography and lymphoscintigraphy are useful to localize the le
PMID 25732972

New Combined Medical Treatment With Etilefrine and Octreotide for Chylothorax After Esophagectomy: A Case Report and Review of the Literature.

Ohkura Y1, Ueno M, Iizuka T, Haruta S, Tanaka T, Udagawa H.
Medicine.Medicine (Baltimore).2015 Dec;94(49):e2214. doi: 10.1097/MD.0000000000002214.
Postoperative chylothorax is a rare but well-known complication of general thoracic surgery. Medical treatment of chylothorax was reported in the past, but there is still considerable controversy on the appropriate management strategies.Two patients with esophageal cancer underwent esophagectomy, 2-
PMID 26656358

Drug Release Properties of a Series of Adenine-Based Metal-Organic Frameworks.

Oh H1, Li T2, An J3.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Nov 16;21(47):17010-5. doi: 10.1002/chem.201501560. Epub 2015 Sep 25.
The drug uptake and release properties of a series of biomolecule-based metal-organic frameworks (bMOF-1, bMOF-4, bMOF-100, and bMOF-102) have been studied. The bMOFs were loaded with the small molecule etilefrine hydrochloride and release profiles were collected in both Nanopure water and simulated
PMID 26403522

Japanese Journal

Octreotide/etilefrine/OK-432併用療法にて治癒した食道癌術後乳糜胸の1例

日本臨床外科学会雑誌 75(6), 1547-1550, 2014
NAID 130004901232

術後リンパ漏にオクトレオチド・エチレフリン併用療法を行った食道癌の1例

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 74(1), 57-62, 2013-01-25
NAID 10031165528

Etilefrine投与が有効であった食道癌術後難治性乳縻胸の1例

日本消化器外科学会雑誌 46(1), 79-84, 2013
NAID 130004908111

Related Pictures

★リンクテーブル★

リンク元	「エチレフリン」
拡張検索	「etilefrine hydrochloride」
関連記事	「etilefrin」

「エチレフリン」

Etilefrine
Systematic (IUPAC) name
	(RS)-3-[2-(ethylamino)-1-hydroxyethyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	709-55-7
ATC code	C01CA01
PubChem	CID 3306
ChemSpider	3190
UNII	ZB6F8MY53V
KEGG	D07931
ChEMBL	CHEMBL86882
Synonyms	(2-ethylamino-1-(3'-hydroxy-phenyl)ethanol
Chemical data
Formula	C10H15NO2
Mol. mass	181.232 g/mol
	SMILES OC(CNCC)c1cc(O)ccc1;
	InChI InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3 ; Key:SQVIAVUSQAWMKL-UHFFFAOYSA-N ;
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