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English Journal

Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys.

Niehoff MO1, Niggemann B2, Sternberg J2, Jenkins A3, Holbrook M4.
Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2014 Sep 16. pii: S1056-8719(14)00262-7. doi: 10.1016/j.vascn.2014.09.004. [Epub ahead of print]
INTRODUCTION: The measurement of cardiovascular endpoints in standard toxicology studies remains a challenge as the routinely used non-invasive methods require physical restraint, causing an increase of sympathetic neural activity, leading to excitement and potentially hypertension in the experiment
PMID 25219539

Development and validation of a hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine.

Kong N1, Yi R, Zhao S, Sandhu J, Lam G, Loganathan D, Morrissey B.
Journal of separation science.J Sep Sci.2014 Aug 20. doi: 10.1002/jssc.201400662. [Epub ahead of print]
A sensitive hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine. The method is highly sensitive and specific with good pr
PMID 25143252

Zabrzewska B, Chyła A, Bogdan A.
Acta poloniae pharmaceutica.Acta Pol Pharm.2014 Jul-Aug;71(4):563-73.
Preservatives are chemical substances whose role is to protect medicinal products against harmful changes caused by microorganisms. They are added to sterile medicinal products, such as eye drops and multidose solutions for injections, as well as to non-sterile products, such as water oral solutions
PMID 25272883

Formation of a Direct Mutagen, Diazo-N-nitrosoetilefrin, by Interaction of Etilefrin with Nitrite

菊川清見,加藤哲太,武田寧
Chemical & pharmaceutical bulletin 37(6), 1600-1603, 1989-06-25
… Reaction of an antihypotensive drug, etilefrin [α-{(ethylamino)methyl}-m-hydroxybenzyl alcohol], with nitrite under mildly acidic conditions produced N-nitrosoetilefrin [α-{(N-nitrosoethylamino)methyl}-m-hydroxybenzyl alcohol] (a mixture of syn and anti forms) (Iab) and diazo-N-nitrosoetilefrin [1-(4-diazo-3-oxo-1,5-cyclohexadienyl-2-(N-nitrosoethylamino)ethanol] (a mixture of syn and anti forms) (IIab). …
NAID 110003627811