関: acrinol、ethacridine

WordNet

a salt or ester of lactic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 07:01:29」(JST)

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Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933. edit
Merck Index, 11th Ed., 3668.

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English Journal

A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.

Kawano S1, Maruyama J1, Nagashima S1, Inami K1, Qiu W1, Iwasa H1, Nakagawa K1, Ishigami-Yuasa M1, Kagechika H2, Nishina H1, Hata Y3.
Journal of biochemistry.J Biochem.2015 May 14. pii: mvv051. [Epub ahead of print]
Transcriptional co-activator with PSD-95/Dlg-A/ZO-1 (PDZ)-binding motif (TAZ) regulates in cell proliferation and differentiation. In mesenchymal stem cells it promotes osteogenesis and myogenesis, and suppresses adipogenesis. TAZ activators are expected to prevent osteoporosis, obesity and muscle a
PMID 25979969

Clinical analyses of 66 cases of mid-trimester pregnancy termination in women with prior cesarean.

Peng P, Liu XY1, Li L, Jin L, Chen WL.
Chinese medical journal.Chin Med J (Engl).2015 Feb 20;128(4):450-4. doi: 10.4103/0366-6999.151073.
BACKGROUND: The rate of cesarean delivery has significantly increased in China in the last decade. Women with prior cesarean history tend to have a higher risk of uterine rupture during termination of the pregnancy in mid-trimester than those without such a history. The aim of our study was to evalu
PMID 25673444

Effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for termination of second trimester pregnancy in patients with liver dysfunction.

Li N1, Wu P, Zhao J, Feng L, Qiao FY, Zeng WJ.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.J Huazhong Univ Sci Technolog Med Sci.2015 Feb;35(1):129-34. doi: 10.1007/s11596-015-1401-x. Epub 2015 Feb 12.
Severe liver dysfunction in pregnancy (SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients wi
PMID 25673206

Japanese Journal

歯周基本治療における咬合状態の変化に関する研究

日本歯周病学会会誌 49(1), 37-46, 2007-03-28
NAID 10027094069

超音波スケーラーのチップを用いた歯周ポケット内洗浄による臨床的および細菌学的効果について

九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 51(6), 842-850, 1997-12-25
NAID 10016252688

Microbial Contamination of Antiseptic-Soaked Cotton Balls

Biological & pharmaceutical bulletin 20(6), 667-669, 1997-06-15
NAID 110003639121

「アクリノール」

Ethacridine lactate
Systematic (IUPAC) name
	7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	1837-57-6
ATC code	B05CA08 D08AA01
PubChem	CID 15789
ChemSpider	15012
KEGG	D01248
ChEMBL	CHEMBL582355
Chemical data
Formula	C18H21N3O4
Molecular mass	343.37
	SMILES O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC;
	InChI InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) ; Key:IYLLULUTZPKQBW-UHFFFAOYSA-N ;
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