関: acrinol、acrinol hydrate、ethacridine lactate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/08 13:04:07」(JST)

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Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933. edit
Merck Index, 11th Ed., 3668.

English Journal

Antibiotics and antiseptics for venous leg ulcers.

O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R.Author information School of Healthcare, University of Leeds, Room LG.12, Baines Wing, Leeds, UK, LS2 9JT.AbstractBACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies are used to prevent and treat clinical infection in venous leg ulcers: systemic antibiotics and topical antibiotics or antiseptics.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2014 Jan 10;1:CD003557. [Epub ahead of print]
BACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies a
PMID 24408354

Antibiotics and antiseptics for venous leg ulcers.

O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R.Author information School of Healthcare, University of Leeds, Room LG.12, Baines Wing, Leeds, UK, LS2 9JT.AbstractBACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies are used to prevent and treat clinical infection in venous leg ulcers: systemic antibiotics and topical antibiotics or antiseptics.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Dec 23;12:CD003557. doi: 10.1002/14651858.CD003557.pub4.
BACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies a
PMID 24363048

A severe dermatologic adverse effect related with gefitinib: case report and review of the literature.

Li YQ, Sun H, Xue D.Author information Department of Integration of TCM and Western Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.AbstractGefitinib, a selective inhibitor of the epidermal growth factor receptor-tyrosine kinase, it's one of the most frequent drug-related adverse effects (AEs) reported in literature is dermatologic AEs. We report, a case of severe cutaneous adverse reactions induced by gefitinib as second-line treatment in a male patient with advanced non-small cell lung cancer after 1 month of treatment. Although tumor shrunk and patient got benefit from the treatment, gefitinib had to be stopped right away. We managed the symptoms of rash with a variety of treatments, including topical ethacridine lactate, antihistamine and so on. After the rash improved, we found his tumor were progress. Then he took gefitinib again without severe skin toxicity or disease progression. We think the development of gefitinib-induced rash may be a sign of effective and administrating it again maybe relieves the degree of rash.
Journal of cancer research and therapeutics.J Cancer Res Ther.2013 Sep;9 Suppl 2:S110-3. doi: 10.4103/0973-1482.119123.
Gefitinib, a selective inhibitor of the epidermal growth factor receptor-tyrosine kinase, it's one of the most frequent drug-related adverse effects (AEs) reported in literature is dermatologic AEs. We report, a case of severe cutaneous adverse reactions induced by gefitinib as second-line treatment
PMID 24135241

Japanese Journal

A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells

The journal of biochemistry 158(5), 413-423, 2015-11
NAID 40020646985

歯周基本治療における咬合状態の変化に関する研究

日本歯周病学会会誌 49(1), 37-46, 2007-03-28
NAID 10027094069

Microbial Contamination of Antiseptic-Soaked Cotton Balls

Biological & pharmaceutical bulletin 20(6), 667-669, 1997-06-15
NAID 110003639121

「アクリノール」

Ethacridine lactate
Systematic (IUPAC) name
	7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1837-57-6
ATC code	B05CA08 D08AA01
PubChem	CID 15789
ChemSpider	15012
KEGG	D01248
ChEMBL	CHEMBL582355
Chemical data
Formula	C18H21N3O4
Mol. mass	343.37
	SMILES O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC;
	InChI InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) ; Key:IYLLULUTZPKQBW-UHFFFAOYSA-N ;
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