アクリノール
- 関
- acrinol hydrate、ethacridine、ethacridine lactate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/03 18:27:55」(JST)
[Wiki en表示]
Ethacridine lactate
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Systematic (IUPAC) name |
7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
1837-57-6 N |
ATC code |
B05CA08 D08AA01 |
PubChem |
CID 15789 |
ChemSpider |
15012 Y |
KEGG |
D01248 Y |
ChEMBL |
CHEMBL582355 Y |
Chemical data |
Formula |
C18H21N3O4 |
Molar mass |
343.37 |
SMILES
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O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC
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InChI
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InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) Y
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Key:IYLLULUTZPKQBW-UHFFFAOYSA-N Y
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NY (what is this?) (verify) |
Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.
Its primary use is as an antiseptic in solutions of 0.1%.
Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.
References
- Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933.
- Merck Index, 11th Ed., 3668.
Antiseptics and disinfectants (D08)
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Acridine derivatives |
- Ethacridine lactate
- 9-Aminoacridine
- Euflavine
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Biguanides and amidines |
- Dibrompropamidine
- Chlorhexidine#
- Propamidine
- Hexamidine
- Polihexanide
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Phenol and derivatives |
- Hexachlorophene
- Policresulen
- Phenol
- Triclosan
- Chloroxylenol#
- Biphenylol
- Fenticlor
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Nitrofuran derivatives |
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Iodine products |
- Iodine/octylphenoxypolyglycolether
- Povidone-iodine#
- Diiodohydroxypropane
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Quinoline derivatives |
- Dequalinium
- Chlorquinaldol
- Oxyquinoline
- Clioquinol
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Quaternary ammonium compounds |
- Benzalkonium
- Benzethonium chloride
- Cetrimonium (bromide/chloride)
- Cetylpyridinium
- Cetrimide
- Benzoxonium chloride
- Didecyldimethylammonium chloride
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Mercurial products |
- Mercuric amidochloride
- Phenylmercuric borate
- Mercuric chloride
- Merbromin
- Thiomersal
- Mercuric iodide
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Silver compounds |
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Alcohols |
- Propanol (propyl alcohol)
- Isopropanol (isopropyl alcohol)
- Ethanol (ethyl alcohol)#
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Other |
- Potassium permanganate
- Sodium hypochlorite
- Hydrogen peroxide
- Eosin
- Tosylchloramide
- Octenidine dihydrochloride
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Antibiotics and antiseptics for venous leg ulcers.
- O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R.Author information School of Healthcare, University of Leeds, Room LG.12, Baines Wing, Leeds, UK, LS2 9JT.AbstractBACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies are used to prevent and treat clinical infection in venous leg ulcers: systemic antibiotics and topical antibiotics or antiseptics.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Dec 23;12:CD003557. doi: 10.1002/14651858.CD003557.pub4.
- BACKGROUND: Venous leg ulcers are a type of chronic wound affecting up to 1% of adults in developed countries at some point during their lives. Many of these wounds are colonised by bacteria or show signs of clinical infection. The presence of infection may delay ulcer healing. Two main strategies a
- PMID 24363048
- Analysis of enzyme activity regulation by non-denaturing electrophoresis and application of this regulation for enzyme reactor production.
- Shimazaki Y, Miki S.Author information Department of Chemistry and Biology, Graduate School of Science and Engineering and Venture Business Laboratory, Ehime University , Matsuyama , Japan.AbstractNon-denaturing electrophoresis can be used to screen enzymes that self-regulate their activities by using a combination of enzymes and their inhibitors. Furthermore, this technique can be applied to develop enzyme reactors that self-regulate their activities. After separation of proteins from mouse liver cytosol by non-denaturing isoelectric focusing, lactate dehydrogense (LDH) and esterase activities were qualitatively and quantitatively examined using a combination of two-dimensional electrophoresis (2-DE) and non-denaturing stacking gel electrophoresis. Activities of mouse liver-derived LDH and carboxylesterase were reversibly inhibited by oxamate and 6,9-diamino-2-ethoxyacridine (acrinol), respectively, in the stacking gels and recovered when the enzymes migrated towards the separation gels. After separation and immobilization of the enzymes, their activities were inhibited by inhibitors and recovered after inhibitor removal. These results indicate that non-denaturing electrophoresis can be applied to select enzymes that self-regulate their activities and subsequently aid in the development of enzyme reactors that can control the enzyme activities.
- Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2013 Oct;28(5):894-9. doi: 10.3109/14756366.2012.693918. Epub 2012 Jul 18.
- Non-denaturing electrophoresis can be used to screen enzymes that self-regulate their activities by using a combination of enzymes and their inhibitors. Furthermore, this technique can be applied to develop enzyme reactors that self-regulate their activities. After separation of proteins from mouse
- PMID 22803677
- A severe dermatologic adverse effect related with gefitinib: case report and review of the literature.
- Li YQ, Sun H, Xue D.Author information Department of Integration of TCM and Western Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.AbstractGefitinib, a selective inhibitor of the epidermal growth factor receptor-tyrosine kinase, it's one of the most frequent drug-related adverse effects (AEs) reported in literature is dermatologic AEs. We report, a case of severe cutaneous adverse reactions induced by gefitinib as second-line treatment in a male patient with advanced non-small cell lung cancer after 1 month of treatment. Although tumor shrunk and patient got benefit from the treatment, gefitinib had to be stopped right away. We managed the symptoms of rash with a variety of treatments, including topical ethacridine lactate, antihistamine and so on. After the rash improved, we found his tumor were progress. Then he took gefitinib again without severe skin toxicity or disease progression. We think the development of gefitinib-induced rash may be a sign of effective and administrating it again maybe relieves the degree of rash.
- Journal of cancer research and therapeutics.J Cancer Res Ther.2013 Sep;9 Suppl 2:S110-3. doi: 10.4103/0973-1482.119123.
- Gefitinib, a selective inhibitor of the epidermal growth factor receptor-tyrosine kinase, it's one of the most frequent drug-related adverse effects (AEs) reported in literature is dermatologic AEs. We report, a case of severe cutaneous adverse reactions induced by gefitinib as second-line treatment
- PMID 24135241
Japanese Journal
- ベンゼトニウム塩化物、グルコン酸クロルヘキシジン、アクリノール水和物の舌処理による鼓索神経応答変化の比較
- 谷口 敬祐,安松 啓子,安尾 敏明,式守 道夫,硲 哲崇
- 日本味と匂学会誌 = The Japanese journal of taste and smell research 19(3), 329-332, 2012-12-01
- NAID 10031172417
- P-027 ベンゼトニウム塩化物、グルコン酸クロルヘキシジン、アクリノール水和物の舌処理による鼓索神経応答変化の比較(ポスターセッション,2012年度日本味と匂学会第46回大会)
- P-040 アクリノール水和物舌処理によるC57BL/6マウスの対ショ糖鼓索神経応答の抑制(ポスターセッション,2011年度日本味と匂学会第45回大会)
Related Links
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- 英
- acrinol、ethacridine、acrinol hydrate
- ラ
- acrinolum
- 同
- 乳酸エタクリジン ethacridine lactate
- 化
- アクリノール水和物 acrinol hydrate
- 商
- リバオール
- 関
- エタクリジン
[★]
エタクリジン、アクリノール
- 関
- acrinol、acrinol hydrate、ethacridine lactate
[★]
乳酸エタクリジン
- 関
- acrinol、ethacridine
[★]
- 関
- acrinol、ethacridine