関: ER-alpha、ERalpha

WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics (同)oestrogen
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any high mountain

PrepTutorEJDIC

アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)
=sense organ / 受信装置
高山,高峰

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/29 21:30:35」(JST)

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Estrogen receptor alpha (ER-α), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ER-α is encoded by the gene ESR1 (EStrogen Receptor 1).^[1]^[2]^[3]

Structure

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.^[4] Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.^[1]^[5]

Coactivators

Coactivators of ER-α include:

SRC-1^[6]^[7]
AIB1 – amplified in breast 1^[8]
BCAS3 – Breast carcinoma amplified sequence 3^[9]
PELP-1 – Proline-, glutamic acid-, leucine-rich protein 1^[10]

Interactions

Estrogen receptor alpha has been shown to interact with:

AKAP13^[11]
AHR^[12]^[13]
BRCA1^[14]^[15]^[16]^[17]
CAV1^[18]
CCNC^[19]
CDC25B^[20]
CEBPB^[21]^[22]
COBRA1^[23]
COUP-TFI^[24]
CREBBP^[17]^[25]
CRSP3^[19]
Cyclin D1^[26]
DDX17^[27]
DDX5^[27]^[28]
DNTTIP2^[29]
EP300^[17]^[19]^[30]
ESR2^[31]^[32]
FOXO1^[33]
GREB1^[34]
GTF2H1^[35]
HSP90AA1^[36]^[37]
ISL1^[38]
JARID1A^[39]
MVP^[40]
MED1^[19]^[41]
MED12^[19]
MED14^[19]
MED16^[19]
MED24^[19]^[41]
MED6^[19]
MGMT^[42]
MNAT1^[43]
MTA1^[44]^[45]
NCOA6^[46]^[47]
NCOA1^[19]^[25]^[27]^[48]^[49]
NCOA2^[27]^[41]^[50]^[51]^[52]
NCOA3^[27]^[53]^[54]
NRIP1^[55]^[56]^[57]
PDLIM1^[58]
POU4F1^[59]
POU4F2^[59]
PRDM2^[60]
PRMT2^[61]
RBM39^[62]
RNF12^[58]
SAFB^[63]^[64]
SAFB2^[65]
SHC1^[66]
SHP^[67]^[68]
SMARCA4^[48]^[69]
SMARCE1^[70]
SRA1^[27]
Src^[42]^[71]^[72]^[73]
TR2^[74]
TR4^[75]
TDG^[76]
TRIM24^[56]^[77] and
XBP1.^[78]

References

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UpToDate Contents

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1. エストロゲン作用の分子生物学および生理学 molecular biology and physiology of estrogen action
2. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
3. 子宮平滑筋腫（子宮筋腫）の組織学的検査および病因 histology and pathogenesis of uterine leiomyomas fibroids
4. 閉経後のホルモン療法と心血管リスク postmenopausal hormone therapy and cardiovascular risk
5. 月経前症候群および月経前不快気分障害の疫学および病因 epidemiology and pathogenesis of premenstrual syndrome and premenstrual dysphoric disorder

English Journal

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells.

Gong P1, Madak-Erdogan Z1, Flaws JA2, Shapiro DJ3, Katzenellenbogen JA4, Katzenellenbogen BS5.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Dec 5;437:190-200. doi: 10.1016/j.mce.2016.08.025. Epub 2016 Aug 16.
Botanical estrogen (BE) dietary supplements are consumed by women as substitutes for loss of endogenous estrogens at menopause. To examine the roles of estrogen receptor α (ERα) and aryl hydrocarbon receptor (AhR) and their crosstalk in the actions of BEs, we studied gene regulation and proliferat
PMID 27543265

G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis.

Wei T1, Chen W1, Wen L1, Zhang J1, Zhang Q1, Yang J1, Liu H1, Chen BW1, Zhou Y1, Feng X2, Yang Q3, Bai X4, Liang T5.
Cancer letters.Cancer Lett.2016 Nov 28;382(2):195-202. doi: 10.1016/j.canlet.2016.08.012. Epub 2016 Sep 1.
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knockout in a diethylnitrosamine (DEN)-induced mouse tum
PMID 27594673

Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats.

Loutchanwoot P1, Vortherms T2, Jarry H2.
Life sciences.Life Sci.2016 Nov 15;165:75-82. doi: 10.1016/j.lfs.2016.09.002. Epub 2016 Sep 8.
AIMS: Previous research has revealed that puerarin, the major phytoestrogen in tuberous roots of Pueraria lobata and Pueraria mirifica, acts as a selective estrogen receptor modulator that displays predominantly estrogenic potential for health benefit. However, little is known about the estrogenic p
PMID 27615593

Japanese Journal

Early indicators of delayed adverse effects in female reproductive organs in rats receiving neonatal exposure to 17alpha-ethynylestradiol

Takahashi Miwa,Inoue Kaoru,Morikawa Tomomi,Matsuo Saori,Hayashi Seigo,Tamura Kei,Watanabe Gen,Taya Kazuyoshi,Yoshida Midori
The Journal of Toxicological Sciences 39(5), 775-784, 2014
… Immunohistochemical expression of estrogen receptor alpha (ERα) in the uterus, serum levels of sex-related hormones and gene expression in the hypothalamus were examined. …
NAID 130004690965

Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells

Terasaka Tomohiro,Otsuka Fumio,Tsukamoto Naoko,Nakamura Eri,Inagaki Kenichi,Toma Kishio,Ogura-Ochi Kanako,Glidewell-Kenney Christine,Lawson Mark A.,Makino Hirofumi
Molecular and Cellular Endocrinology 381(1-2), 8-15, 2013-12-05
… Kisspeptin, the peptide product of the kiss1 gene and the endogenous agonist for the GRP54 receptor, plays a key role in the regulation of GnRH secretion. … In the present study, we investigated the interaction between kisspeptin, estrogen and BMPs in the regulation of GnRH production by using mouse hypothalamic GT1-7 cells. … The expression of kisspeptin receptor, GPR54, was suppressed by BMPs, and this effect was reversed in the presence of kisspeptin. …
NAID 120005468285

特徴的な経過を呈した子宮筋腫肺転移の2例

角岡信男,平山杏,稲沢慶太郎
日本臨床外科学会雑誌 74(9), 2428-2433, 2013
… 認めず．ともに胸腔鏡下肺部分切除施行した．永久病理では共に平滑筋腫であり，免疫染色ではαSMA（+），desmin（+），caldesmon（-），S-100（-），MIB-1 labering index（低値），estrogen receptor（+），progesterone receptor（+）であった．症例2は23年前に子宮筋腫での手術既往あり，症例1は未治療の子宮筋腫を認め術後子宮全摘および両側付属器切除を施行した．両症例とも子宮筋腫肺転移と …
NAID 130004901166

「エストロゲン受容体α」

Estrogen receptor 1
	; PDB rendering based on 1a52.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1A52, 1AKF, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4O6F, 4PP6, 4PPP, 4PPS
Identifiers
Symbols	ESR1 ; ER; ESR; ESRA; ESTRR; Era; NR3A1
External IDs	OMIM: 133430 MGI: 1352467 HomoloGene: 47906 IUPHAR: 620 ChEMBL: 206 GeneCards: ESR1 Gene
Gene ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding; • core promoter sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • chromatin binding; • sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • steroid binding; • protein binding; • beta-catenin binding; • transcription factor binding; • zinc ion binding; • enzyme binding; • nitric-oxide synthase regulator activity; • estrogen receptor activity; • estrogen response element binding; • estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • identical protein binding;
Cellular component	• nucleus; • nucleoplasm; • Golgi apparatus; • plasma membrane; • membrane; • integral component of membrane;
Biological process	• antral ovarian follicle growth; • epithelial cell development; • chromatin remodeling; • transcription, DNA-templated; • regulation of transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • signal transduction; • phospholipase C-activating G-protein coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • androgen metabolic process; • male gonad development; • gene expression; • negative regulation of gene expression; • positive regulation of phospholipase C activity; • intracellular steroid hormone receptor signaling pathway; • intracellular estrogen receptor signaling pathway; • response to estradiol; • regulation of apoptotic process; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • steroid hormone mediated signaling pathway; • negative regulation of sequence-specific DNA binding transcription factor activity; • response to estrogen; • positive regulation of nitric oxide biosynthetic process; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of fibroblast proliferation; • positive regulation of retinoic acid receptor signaling pathway; • positive regulation of nitric-oxide synthase activity; • positive regulation of sequence-specific DNA binding transcription factor activity; • uterus development; • vagina development; • prostate epithelial cord elongation; • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; • regulation of branching involved in prostate gland morphogenesis; • mammary gland branching involved in pregnancy; • mammary gland alveolus development; • epithelial cell proliferation involved in mammary gland duct elongation; • cellular response to estradiol stimulus;
	Sources: Amigo / QuickGO
Orthologs
	This box: view; talk; edit;

　　[★]

英: estrogen receptor alpha、ERalpha、ER-alpha
関: エストロゲンレセプターα

「ERalpha」

　　[★]

エストロゲン受容体α

関: ER-alpha、estrogen receptor alpha

「エストロゲンレセプターα」

　　[★]

英: estrogen receptor alpha
関: エストロゲン受容体α

「alpha」

　　[★]

α、アルファ

関: alfa

「estrogen receptor」

　　[★] エストロゲン受容体 ER

[entrez-1] "Entrez Gene: ESR1 estrogen receptor 1".

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リンク元	「エストロゲン受容体α」「ERalpha」「エストロゲンレセプターα」
関連記事	「alpha」「estrogen receptor」

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estrogen receptor alpha