腸クロム親和性細胞様細胞
WordNet
- want to have; "Id like a beer now!"
- a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
- a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
- equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
- resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
- be fond of; "I like my nephews"
- feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
- find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
- found pleasant or attractive; often used as a combining form; "a well-liked teacher"
- Chinese distance measure; approximately 0.5 kilometers
PrepTutorEJDIC
- …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
- (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- (…の)『好み』,趣味《+『for』(『to』)+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/24 16:54:46」(JST)
[Wiki en表示]
Not to be confused with Enterochromaffin cell.
| Enterochromaffin-like cell |
|
Control of stomach acid secretions. (ECL-cell at top center.)
|
| Details |
| Identifiers |
| Latin |
endocrinocytus ECL |
| Code |
TH H3.04.02.0.00030 |
| TH |
H3.04.02.0.00030 |
| Anatomical terminology
[edit on Wikidata]
|
Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa beneath the epithelium, in particular in the vicinity of parietal cells, that aid in the production of gastric acid via the release of histamine. They are also considered a type of enteroendocrine cell.[1]
Contents
- 1 Function
- 2 Pathology
- 3 Name
- 4 See also
- 5 References
Function
ECL cells synthesize and secrete histamine. These cells are stimulated by the hormones gastrin (not depicted in the adjacent diagram) and pituitary adenylyl cyclase-activating peptide. G cells are stimulated by vagal stimulation through the neurotransmitter gastrin-releasing peptide; this causes the G cells to secrete gastrin, which in turn stimulates ECL cells to release histamine. Note that this circuit is not activated by acetylcholine, which is of particular importance because the administration of atropine will not block the vagal stimulation of the G cells, as ACh is not the neurotransmitter for these cells.
However, ECL cells are activated directly by ACh on M1 receptors from direct vagal innervation leading to histamine release. This pathway will be inhibited by atropine.[2]
Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood. Histamine and gastrin act synergistically as the most important stimulators of hydrochloric acid secretion from parietal cells and stimulators of secretion of pepsinogen from chief cells. The most important inhibitor of the ECL cell is somatostatin from oxyntic D cells.
Enterochromaffin-like cells also produce pancreastatin and probably other peptide hormones and growth factors.
Pathology
A prolonged stimulation of these cells causes their hyperplasia. This is especially important in gastrinoma (the tumors in which there is an excessive secretion of gastrin), as this is one of the factors contributing to Zollinger–Ellison's syndrome. It was once believed that tumors of ECL origin form after a prolonged inhibition of gastric acid secretion, however there is no data to support this conclusion and proton pump inhibitors are not thought to contribute to gastric cancer[citation needed].
Name
The name is derived from their location in the enteric system and their chromaffin-like staining pattern in histologic sections, which is characterized by silver staining.
See also
- Enterochromaffin cell
- Chromaffin cell
References
- ^ Enterochromaffin-like Cells at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Tobin G, Giglio D, Lundgren O (2009). "Muscarinic receptor subtypes in the alimentary tract" (PDF). Journal of Physiology and Pharmacology. 60 (1): 3–21. PMID 19439804.
|
Physiology of the gastrointestinal system
|
| GI tract |
| Upper |
| Exocrine |
- Chief cells
- Parietal cells
- Gastric acid
- Intrinsic factor
- Foveolar cells
- Goblet cells
|
| Processes |
|
| Fluids |
|
|
| Lower |
| Enteric nervous system |
- Submucous plexus
- Myenteric plexus
|
| Endocrine/paracrine |
- G cells
- D cells
- ECL cells
|
| enterogastrone: |
|
- Enteroendocrine cells
- Enterochromaffin cell
- APUD cell
|
|
| Fluids |
|
| Processes |
- Segmentation contractions
- Migrating motor complex
- Borborygmus
- Defecation
|
|
| Either/both |
| Processes |
- Peristalsis (Interstitial cell of Cajal
- Basal electrical rhythm)
- Gastrocolic reflex
- Digestion
|
|
|
| Accessory |
| Fluids |
|
| Processes |
- Enterohepatic circulation
|
|
| Abdominopelvic |
|
|
Cells in humans derived from endoderm
|
| Foregut |
| Respiratory |
- Pneumocyte
- Club cell
- Goblet cell
|
| Digestive |
| Stomach |
- Enteroendocrine cell
- G cell
- Delta cell
- Enterochromaffin-like cell
- Gastric chief cell
- Parietal cell
- Foveolar cell
|
| Intestine |
- Enteroendocrine cell
- Gastric inhibitory polypeptide
- S cell
- Delta cell
- Cholecystokinin
- Goblet cell
- Paneth cell
- Tuft cell
- Enterocyte
|
| Liver |
- Hepatocyte
- Hepatic stellate cell
- (Kupffer cell from mesoderm)
|
| Gallbladder |
|
| Exocrine pancreas |
- Centroacinar cell
- Pancreatic stellate cell
|
|
| Islets of Langerhans |
- alpha cell
- beta cell
- delta cell
- F cell(PP cell
- epsilon cell
|
|
| Pharyngeal pouch |
- Thyroid gland
- Parathyroid gland
- Parathyroid chief cell
- Oxyphil cell
|
| Hindgut/cloaca |
|
UpToDate Contents
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English Journal
- Somatostatin analogs for gastric carcinoids: For many, but not all.
- Massironi S1, Zilli A1, Conte D1.
- World journal of gastroenterology : WJG.World J Gastroenterol.2015 Jun 14;21(22):6785-93. doi: 10.3748/wjg.v21.i22.6785.
- Gastric carcinoids (GCs) are classified as: type I, related to hypergastrinemia due to chronic atrophic gastritis (CAG), type II, associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1, and type III, which is normogastrinemic. The management of type-I gastric carcinoid
- PMID 26078554
- Pediatric non-helicobacter pylori atrophic gastritis: a case series.
- Pogoriler J1, Kamin D, Goldsmith JD.
- The American journal of surgical pathology.Am J Surg Pathol.2015 Jun;39(6):786-92. doi: 10.1097/PAS.0000000000000378.
- Although autoimmune atrophic gastritis is classically a disease of elderly adults, recent studies have described the disease in younger adults, particularly in those with other autoimmune diseases and iron-deficiency anemia. Atrophic gastritis in pediatrics is a rare and possibly underdiagnosed enti
- PMID 25602795
- Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.
- Waldum HL1, Hauso Ø, Sørdal ØF, Fossmark R.
- Digestive diseases and sciences.Dig Dis Sci.2015 Jun;60(6):1522-7. doi: 10.1007/s10620-014-3468-9. Epub 2014 Dec 6.
- Gastric cancer occurs almost exclusively in patients with gastritis. Since Helicobacter pylori (Hp) was proved to cause gastritis, Hp was also expected to play a role in gastric carcinogenesis. Despite extensive studies, the mechanisms by which Hp cause gastric cancer are still poorly understood. Ho
- PMID 25480404
Japanese Journal
- 幽門洞切除によって全腫瘍を消失しえたA型胃炎に伴う多発性胃カルチノイドの1例
- 日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 57(8), 366, 2010-08-15
- NAID 10026526056
- Unusual Multiple Gastric Carcinoids with Hypergastrinemia : Report of a Case
- Surgery today : the Japanese journal of surgery 40(3), 267-271, 2010-03-01
- NAID 10027394684
Related Links
- Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like cells (ECL), are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition ...
- Enterochromaffin-like (ECL) cells, in contrast to EC cells, are confined to a single region of the gut, the gastric fundus, where they form the major endocrine cell population. ECL cells have no lumenal connection (Fig. 6). The cells are ...
- Histamine from enterochromaffin-like cells in the stomach stimulates acid secretion by parietal cells, an action that is insensitive to the classic antihistamines (H1). Development of H2 receptor antagonists by Jim Black revolutionized ...
★リンクテーブル★
[★]
- 英
- enterochromaffin-like cell, ECL cell,enterochromaffin-like cells, ECL cells
- 同
- ECL細胞
- 胃の壁細胞に近接して存在し、ヒスタミンを分泌する。これにより壁細胞からの胃酸分泌を促す。
[★]
腸クロム親和性細胞様細胞 ECL cells
[★]
- 関
- alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such
[★]
[★]
細胞