エノイルACP還元酵素、エノイルACPレダクターゼ、エノイルアシルキャリアータンパク質還元酵素
- 関
- enoyl-(acyl-carrier protein)reductase
WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- an enzyme that catalyses the biochemical reduction of some specified substance
PrepTutorEJDIC
- answer / ampere
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/13 16:49:43」(JST)
[Wiki en表示]
| Enoyl-acyl carrier protein reductase |
| Identifiers |
| EC number |
1.3.1.9 |
| CAS number |
37251-08-4 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system. [1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.[2]
At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.[3]
See also
- Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
- Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
- Cis-2-enoyl-CoA reductase (NADPH)
References
- ^ Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum. / Biochem J. 2004 Aug 1;381(Pt 3):735-41. PMID 15139852
- ^ Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase. / Antimicrob Agents Chemother. 2004 May;48(5):1541-7. PMID 15105103
- ^ Zheng CJ, Sohn MJ, Kim WG. (2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae". Journal of Antibiotics 59 (12): 808–12. doi:10.1038/ja.2006.108. PMID 17323650.
External links
- NADH-Enoyl ACP Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 1.3.1.9
|
Metabolism: lipid metabolism / fatty acid metabolism, triglyceride and fatty acid enzymes
|
|
| Synthesis |
| Malonyl-CoA synthesis |
- ATP citrate lyase
- Acetyl-CoA carboxylase
|
|
Fatty acid synthesis/
Fatty acid synthase |
- Beta-ketoacyl-ACP synthase
- Β-Ketoacyl ACP reductase
- 3-Hydroxyacyl ACP dehydrase
- Enoyl ACP reductase
|
|
| Fatty acid desaturases |
- Stearoyl-CoA desaturase-1
|
|
| Triacyl glycerol |
- Glycerol-3-phosphate dehydrogenase
- Thiokinase
|
|
|
| Degradation |
| Acyl transport |
- Carnitine palmitoyltransferase I
- Carnitine-acylcarnitine translocase
- Carnitine palmitoyltransferase II
|
|
| Beta oxidation |
| General |
- Acyl CoA dehydrogenase (ACADL
- ACADM
- ACADS
- ACADVL
- ACADSB)
- Enoyl-CoA hydratase
- Acetyl-CoA C-acyltransferase
|
|
| Unsaturated |
- Enoyl CoA isomerase
- 2,4 Dienoyl-CoA reductase
|
|
| Odd chain |
- Propionyl-CoA carboxylase
|
|
| Other |
- Hydroxyacyl-Coenzyme A dehydrogenase
|
|
|
| To acetyl-CoA |
- Malonyl-CoA decarboxylase
|
|
| Aldehydes |
- Long-chain-aldehyde dehydrogenase
|
|
|
|
Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
|
|
| 1.3.1: NAD/NADP acceptor |
- Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
- 7-Dehydrocholesterol reductase
- Biliverdin reductase
- 2,4 Dienoyl-CoA reductase
- Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
|
|
| 1.3.3: Oxygen acceptor |
- Dihydroorotate dehydrogenase
- Coproporphyrinogen III oxidase
- Protoporphyrinogen oxidase
- Bilirubin oxidase
- Acyl-CoA oxidase
- Dihydrouracil oxidase
- Tetrahydroberberine oxidase
- Secologanin synthase
- Tryptophan alpha,beta-oxidase
- Pyrroloquinoline-quinone synthase
- L-galactonolactone oxidase
|
|
| 1.3.5: Quinone |
|
|
| 1.3.99: Other acceptors |
- Fumarate reductase
- Butyryl-CoA dehydrogenase
- Acyl CoA dehydrogenase
- 5α-reductase
- Glutaryl-CoA dehydrogenase
- Isovaleryl coenzyme A dehydrogenase
- 3-oxo-5beta-steroid 4-dehydrogenase
|
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Isoflavone Dimers and Other Bioactive Constituents from the Figs of Ficus mucuso.
- Bankeu JJ, Khayala R, Lenta BN, Noungoue DT, Ngouela SA, Mustafa SA, Asaad K, Choudhary MI, Prigge ST, Hasanov R, Nkengfack AE, Tsamo E, Ali MS.SourceDepartment of Organic Chemistry, Faculty of Science, TWAS Research Unit of the University of Yaounde I , P.O. Box 812, Yaounde, Cameroon.
- Journal of natural products.J Nat Prod.2011 Jun 24;74(6):1370-1378. Epub 2011 May 27.
- Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falci
- PMID 21619045
- Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.
- Cho JY, Kwon YJ, Sohn MJ, Seok SJ, Kim WG.SourceKorea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2011 Mar 15;21(6):1716-8. Epub 2011 Jan 22.
- A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also s
- PMID 21316961
Japanese Journal
- Aquastatin A, a New Inhibitor of Enoyl-Acyl Carrier Protein Reductase from Sporothrix sp. FN611
- Kwon Yun-Ju,Fang Yi,Xu Guang-Hua,Kim Won-Gon
- Biological & Pharmaceutical Bulletin 32(12), 2061-2064, 2009
- … Bacterial enoyl-acyl carrier protein (ACP) reductase has been confirmed as a novel target for antibacterial drug development. … FN611 potently inhibited the enoyl-ACP reductase (FabI) of Staphylococcus aureus. …
- NAID 130000116996
- Antisense Expression of 3-Oxoacyl-ACP Reductase Affects Whole Plant Productivity and Causes Collateral Changes in Activity of Fatty Acid Synthase Components
- O'HARA Paul,SLABAS Antoni R.,FAWCETT Tony
- Plant and cell physiology 48(5), 736-744, 2007-05-01
- NAID 10027002037
Related Links
- 1. Biochemistry. 2010 Feb 16;49(6):1281-9. doi: 10.1021/bi902001a. Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei. Lu H, Tonge PJ. Institute for Chemical Biology and Drug Discovery ...
- Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA * ... Enoyl-ACP reductases catalyze the final step in the elongation cycle of the bacterial ...
★リンクテーブル★
[★]
- 英
- reductase
- 関
- エノイルアシルキャリアータンパク質レダクターゼ、エノイルACP還元酵素、エノイルACPレダクターゼ
[★]
エノイルアシルキャリアータンパク質還元酵素、エノイルアシルキャリアータンパク質レダクターゼ
- 関
- enoyl-ACP reductase
[★]
- 英
- enoyl-ACP reductase
- 関
- エノイルアシルキャリアータンパク質還元酵素、エノイルACPレダクターゼ
[★]
- 英
- enoyl-ACP reductase
- 関
- エノイルアシルキャリアータンパク質還元酵素、エノイルACP還元酵素
[★]
- (酵素)還元酵素、レダクターゼ、リダクターゼ
- 関
- dehydrogenase、oxidase、oxidoreductase、reducing enzyme
[★]
[★]
[★]
アシルキャリアータンパク質