WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 心不全におけるエンドセリンの役割 role of endothelin in heart failure
2. 成人における肺高血圧症の治療 treatment of pulmonary hypertension in adults
3. エンドセリンと腎臓 endothelin and the kidney
4. 進行性前立腺癌の治療に対する実験的アプローチ investigational approaches for the treatment of advanced prostate cancer
5. 狭心症の新しい治療法 new therapies for angina pectoris

Yoon S, Zuccarello M, Rapoport RM.SourceResearch Service, Veterans Affairs Medical Center, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, PO Box 670575, Cincinnati, OH, 45267-0575, USA.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2012 Jan 19. [Epub ahead of print]
The rationale for the therapeutic use of dual as opposed to selective endothelin (ET) receptor antagonists stems in part from cross-talk between the ET(A) and ET(B) receptors. However, whether ET(A)-ET(B) receptor cross-talk is present in the cerebral vasculature is difficult to discern since findin
PMID 22258095

Collecting duct-specific endothelin B receptor knockout increases ENaC activity.

Bugaj V, Mironova E, Kohan DE, Stockand JD.SourceDepartment of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA.
American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2012 Jan;302(1):C188-94. Epub 2011 Sep 14.
Collecting duct (CD)-derived endothelin-1 (ET-1) acting via endothelin B (ETB) receptors promotes Na(+) excretion. Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure. Activity of the epithelial Na(+) channel (ENaC) is limiting for Na(+) reabsor
PMID 21918182

エンドセリン受容体のユビキチン化 : ユビキチン化によるエンドセリン受容体の細胞内トラフィッキング制御 (特集 Gタンパク質共役型受容体の活性制御にかかわる分子群の新展開)

寺田晃士,堀之内孝広,東恒仁 [他]
日本薬理学雑誌 = Folia pharmacologica Japonica : くすりとからだ : ファーマコロジカ 145(1), 4-9, 2015-01
NAID 40020312340

佐地勉,中山智孝,高月晋一,池原聡,嶋田博光,直井和之,佐藤真理,松裏裕行
日本小児循環器学会雑誌 31(4), 157-183, 2015
小児期PAHの薬物療法を行うにあたって，臨床医は小児は成人と異なり様々な特色があることを再認識しなければならない．すなわち，代謝酵素活性（p450など），受容体の濃度（密度）や感受性，器官の機能発達（特に腎臓と肝臓，心筋代謝），体脂肪の容積，蛋白（アルブミン）結合率，血中蛋白濃度，分散容積，薬物動態PKや薬力学PD，一定の年齢だけ反応する臓器（動脈管など），薬理遺伝子的背景，　遺伝子多型などによる …
NAID 130005098178