endothelin A receptor

• エンドセリンA受容体、エンドセリンAレセプター

WordNet

1. the 1st letter of the Roman alphabet (同)a
2. the blood group whose red cells carry the A antigen (同)type_A, group A
3. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. answer / ampere
2. =sense organ / 受信装置
3. arsenicの化学記号

UpToDate Contents

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• 1. Role of endothelin in heart failure with reduced ejection fraction
• 2. エンドセリンと腎臓 endothelin and the kidney
• 3. 全身性硬化症（強皮症）における肺血管疾患：治療 pulmonary vascular disease in systemic sclerosis scleroderma treatment
• 4. 成人における肺高血圧症の治療 treatment of pulmonary hypertension in adults
• 5. 降圧療法と慢性腎臓病の進行：実験的研究 antihypertensive therapy and progression of chronic kidney disease experimental studies

English Journal

• Atrasentan in Patients With Advanced Renal Cell Carcinoma: A Phase 2 Trial of the ECOG-ACRIN Cancer Research Group (E6800).

• Carducci MA1, Manola J2, Nair SG3, Liu G4, Rousey S5, Dutcher JP6, Wilding G7.
• Clinical genitourinary cancer.Clin Genitourin Cancer.2015 Dec;13(6):531-539.e1. doi: 10.1016/j.clgc.2015.07.002. Epub 2015 Jul 17.
• BACKGROUND: Atrasentan, an oral endothelin receptor A antagonist, demonstrated phase 1 activity in patients with renal cell carcinoma (RCC). A phase 2 study was undertaken in patients with measurable or bone-only metastatic RCC in the pre-VEGF/TKI era.METHODS AND MATERIALS: Patients were stratified
• PMID 26272427

• Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.

• Semprucci E1, Tocci P1, Cianfrocca R1, Sestito R1, Caprara V1, Veglione M1, Castro VD1, Spadaro F2, Ferrandina G3, Bagnato A1, Rosanò L1.
• Oncogene.Oncogene.2015 Nov 2. doi: 10.1038/onc.2015.403. [Epub ahead of print]
• The endothelin-1 (ET-1)/ET A receptor (ETAR) signalling pathway is a well-established driver of epithelial ovarian cancer (EOC) progression. One key process promoted by ET-1 is tumor cell invasion, which requires the scaffolding functions of β-arrestin-1 (β-arr1) downstream of the receptor; howeve
• PMID 26522724

• Endothelin ETA receptor antagonist reverses naloxone-precipitated opioid withdrawal in mice.

• Bhalla S1, Pais G1, Tapia M2, Gulati A1.
• Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 Nov;93(11):935-44. doi: 10.1139/cjpp-2015-0022. Epub 2015 Apr 28.
• Long-term use of opioids for pain management results in rapid development of tolerance and dependence leading to severe withdrawal symptoms. We have previously demonstrated that endothelin-A (ETA) receptor antagonists potentiate opioid analgesia and eliminate analgesic tolerance. This study was desi
• PMID 26440527

Japanese Journal

• Genetic factors associating the effects of habitual exercise on arterial stiffness

• Iemitsu Motoyuki
• The Journal of Physical Fitness and Sports Medicine 2(3), 325-332, 2013
• … Recently, several studies reported that gene polymorphisms, such as atrial natriuretic peptide, endothelial nitric oxide synthase, estrogen receptor-α, endothelin receptor-A, endothelin receptor-B, angiotensinogen, angiotensin-converting enzyme, methylenetetrahydrofolate reductase and fatty acid binding protein 2, were associated with individual variation in the effects of physical exercise or cardiorespiratory fitness on arterial stiffness risks. …
• NAID 130003379974

• Vascular Endothelial σ1-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding

• Tagashira Hideaki,Matsumoto Takayuki,Taguchi Kumiko,Zhang Chen,Han Feng,Ishida Keiko,Nemoto Shingo,Kobayashi Tsuneo,Fukunaga Kohji
• Circulation Journal, 2013
• … Background: We previously reported that σ1-receptor (σ1R) expression in the thoracic aorta decreased after pressure overload (PO) induced by abdominal aortic banding in ovariectomized (OVX) rats. … Vascular functions of isolated descending aorta were measured following phenylephrine (PE)- or endothelin-1 (ET-1)-induced vasoconstriction and acetylcholine (ACh)- or clonidine-induced vasodilation. …
• NAID 130003361844

• Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension

• Nakamura Atsuhiro,Nagaya Noritoshi,Obata Hiroaki,Sakai Katsuya,Sakai Yoshiki,Yoshikawa Masanori,Hamada Kaoru,Matsumoto Kunio,Kimura Hiroshi
• Circulation Journal, 2013
• … Kaplan-Meier survival curves demonstrated that the effect of ONO-1301 was equivalent to that of an endothelin receptor antagonist and a phosphodiesterase-5 inhibitor. …
• NAID 130003361765

Related Links

• Endothelin receptor A (IPR002175) < InterPro < EMBL-EBI

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource ...

• EDNRA endothelin receptor type A [ (human)]

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a ...

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★リンクテーブル★

リンク元	「エンドセリンAレセプター」
関連記事	「A」「Ad」

「エンドセリンAレセプター」

　　[★]

英

endothelin A receptor

関

エンドセリンA受容体

「A」

　　[★]

• アデニン adenine
• アデノシン adenosine
• アラニン alanine

　 　 　

「Ad」

　　[★]

• アデノウイルス

関

adenoviral、adenovirus