エンドヌクレアーゼV
- 関
- pyrimidine dimer-specific endonuclease
WordNet
- the 22nd letter of the Roman alphabet (同)v
- a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes
PrepTutorEJDIC
- vanadium の化学記号
- verb / verso / 《話》very / velocity / volt[s] / volume / vide
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/29 21:02:50」(JST)
[Wiki en表示]
Deoxyribodipyrimidine endonucleosidase |
Identifiers |
EC number |
3.2.2.17 |
CAS number |
75302-33-9 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Deoxyribodipyrimidine endonucleosidase (EC 3.2.2.17, pyrimidine dimer DNA-glycosylase, endonuclease V, deoxyribonucleate pyrimidine dimer glycosidase, pyrimidine dimer DNA glycosylase, T4-induced UV endonuclease, PD-DNA glycosylase) is an enzyme with system name deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase.[1] This enzyme catalyses the following chemical reaction
- Cleaves the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue
References
- ^ Haseltine, W.A., Gordon, L.K., Lindan, C.P., Grafstrom, R.H., Shaper, N.L. and Grossman, L. (1980). "Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus". Nature 285: 634–641. doi:10.1038/285634a0. PMID 6248789.
External links
- Deoxyribodipyrimidine endonucleosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Chemoprevention of nonmelanoma skin cancer.
- Soltani-Arabshahi R, Tristani-Firouzi P.SourceDepartment of Dermatology, University of Utah, Salt Lake City, Utah.
- Facial plastic surgery : FPS.Facial Plast Surg.2013 Oct;29(5):373-83. doi: 10.1055/s-0033-1353377. Epub 2013 Sep 13.
- Chemoprevention is suitable for patients who are at high risk of development of numerous or invasive nonmelanoma skin cancers (NMSCs). Various substances have been studied as potential chemopreventive agents for NMSC. Oral retinoids have been proven to be effective in the suppression of new squamous
- PMID 24037930
- The excision of 3' penultimate errors by DNA polymerase I and its role in endonuclease V-mediated DNA repair.
- Lee CC, Yang YC, Goodman SD, Lin CJ, Chen YA, Wang YT, Cheng WC, Lin LI, Fang WH.SourceDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, 100-02, Taiwan, ROC.
- DNA repair.DNA Repair (Amst).2013 Sep 4. pii: S1568-7864(13)00187-0. doi: 10.1016/j.dnarep.2013.08.003. [Epub ahead of print]
- Deamination of adenine can occur spontaneously under physiological conditions, and is enhanced by exposure of DNA to ionizing radiation, UV light, nitrous acid, or heat, generating the highly mutagenic lesion of deoxyinosine in DNA. Such DNA lesions tends to generate A:T to G:C transition mutations
- PMID 24012058
- Endonuclease V: an unusual enzyme for repair of DNA deamination.
- Cao W.SourceDepartment of Genetics and Biochemistry, South Carolina Experiment Station, Clemson University, Room 049 Life Science Building, 190 Collings Street, Clemson, SC, 29634, USA, wgc@clemson.edu.
- Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2013 Sep;70(17):3145-56. doi: 10.1007/s00018-012-1222-z. Epub 2012 Dec 20.
- Endonuclease V (endo V) was first discovered as the fifth endonuclease in Escherichia coli in 1977 and later rediscovered as a deoxyinosine 3' endonuclease. Decades of biochemical and genetic investigations have accumulated rich information on its role as a DNA repair enzyme for the removal of deami
- PMID 23263163
Japanese Journal
- Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA
- Takahashi Daisuke,Sato Koichi,Hirayama Emiko [他]
- The journal of biochemistry 158(3), 263-270, 2015-09
- NAID 40020593603
- Development of a practical NF1 genetic testing method through the pilot analysis of five Japanese families with neurofibromatosis type 1
- Okumura Akiko,Ozaki Mamoru,Niida Yo
- Brain and Development 37(7), 677-689, 2015-08-01
- … Methods: Our original method, CEL endonuclease mediated heteroduplex incision with polyacrylamide gel electrophoresis and silver staining (CHIPS) was optimized for NF1 mutation screening, and reverse transcription polymerase chain reaction (RT-PCR) was performed to determine the effect of transcription. …
- NAID 120005593951
- DNAミスマッチ修復系におけるDNA切断活性の制御機構
Related Links
- アプリケーション DNAのUV損傷1および修復の研究(単一細胞のDNA損傷研究²など) 転写された配列のUV損傷特異的修復の検出 2,3 UV突然変異のホットスポットの検出 6,7 T4 Endonuclease VにはN-グリコシラーゼおよび脱プリン・脱 ...
- 特徴 組換え体から単離 10X反応バッファー付属 Description: エンドヌクレアーゼ Vは、デオキシイノシンを認識する修復酵素である。デオキシイノシンとは、E. coliのDNAにあるデオキシアデノシンの脱アミノ反応の産物としてみられる。
★リンクテーブル★
[★]
- 英
- endonuclease V
- 関
- ピリミジンダイマー特異的エンドヌクレアーゼ
[★]
- 関
- endonuclease V
[★]
[★]
エンドヌクレアーゼ、・リヌクレオチド内部加水分解酵素
[★]