WordNet

the 9th letter of the Roman alphabet (同)i
a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes

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1. 光線角化症の治療 treatment of actinic keratosis
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Lin WY, Wilson JH, Lin Y.SourceVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
DNA repair.DNA Repair (Amst).2013 Jul;12(7):480-7. doi: 10.1016/j.dnarep.2013.04.024. Epub 2013 May 23.
Double-strand breaks (DSBs), a common type of DNA lesion, occur daily in human cells as a result of both endogenous and exogenous damaging agents. DSBs are repaired in two general ways: by the homology-dependent, error-free pathways of homologous recombination (HR) and by the homology-independent, e
PMID 23707303

Yasui A.SourceDivision of Dynamic Proteome, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980-8575, Japan.
Cold Spring Harbor perspectives in biology.Cold Spring Harb Perspect Biol.2013 Jun 1;5(6). pii: a012617. doi: 10.1101/cshperspect.a012617.
Alternative excision repair (AER) is a category of excision repair initiated by a single nick, made by an endonuclease, near the site of DNA damage, and followed by excision of the damaged DNA, repair synthesis, and ligation. The ultraviolet (UV) damage endonuclease in fungi and bacteria introduces
PMID 23645854

Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.

Mohapatra S, Yannone SM, Lee SH, Hromas RA, Akopiants K, Menon V, Ramsden DA, Povirk LF.SourceDepartment of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States.
DNA repair.DNA Repair (Amst).2013 Jun 1;12(6):422-32. doi: 10.1016/j.dnarep.2013.03.005. Epub 2013 Apr 18.
Both Metnase and Artemis possess endonuclease activities that trim 3' overhangs of duplex DNA. To assess the potential of these enzymes for facilitating resolution of damaged ends during double-strand break rejoining, substrates bearing a variety of normal and structurally modified 3' overhangs were
PMID 23602515

3'-Blocking Damage of DNA as a Mutagenic Lesion Caused by Hydrogen Peroxide in Escherichia coli

Takemoto Tadashi,Zhang Qiu-Mei,Matsumoto Yukiko [他],MITO SEIJI,IZUMI TADAHIDE,IKEHATA HIRONOBU,YONEI SHUJI
Journal of radiation research 39(2), 137-144, 1998-06
… AP sites and 3'-blocking damage are repairable by exonuclease III and endonuclease IV in Escherichia coli. … coli, which are deficient in exonuclease III and endonuclease IV, were highly sensitive to lethal and mutagenic effects of H_2O_2 , compared with the wild-type strains. … The nfo-186 gene product, Nfo186, retained normal AP endonuclease activity but could not remove 3'-blocking damage from DNA. …
NAID 110002328146