- 関
- eIF-2 kinase
WordNet
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
UpToDate Contents
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- 1. 消失性白質疾患（Vanishing white matter disease） vanishing white matter disease
- 2. 成人における肺静脈閉塞症の疫学、病因、臨床評価および診断 epidemiology pathogenesis clinical evaluation and diagnosis of pulmonary veno occlusive disease in adults
- 3. ホスホリラーゼbキナーゼ欠損症 phosphorylase b kinase deficiency
- 4. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症 phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency
- 5. リウマチ性疾患のマネージメントに用いる生物学的製剤とキナーゼ阻害薬の概要 overview of biologic agents and kinase inhibitors in the rheumatic diseases
English Journal
- Small molecule modulators of eukaryotic initiation factor 2α kinases, the key regulators of protein synthesis.
- Joshi M, Kulkarni A, Pal JK.SourceBioinformatics Center, University of Pune, Pune - 411007, Maharashtra, India. Electronic address: manali@bioinfo.net.in.
- Biochimie.Biochimie.2013 Nov;95(11):1980-90. doi: 10.1016/j.biochi.2013.07.030. Epub 2013 Aug 11.
- Eukaryotic initiation factor 2 alpha kinases (eIF-2α kinases) are key mediators of stress response in cells. In mammalian cells, there are four eIF-2α kinases, namely HRI (Heme-Regulated Inhibitor), PKR (RNA-dependent Protein Kinase), PERK (PKR-like ER Kinase) and GCN2 (General Control Non-derepre
- PMID 23939221
- Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.
- Joassard OR, Amirouche A, Gallot YS, Desgeorges MM, Castells J, Durieux AC, Berthon P, Freyssenet DG.SourceLaboratoire de Physiologie de l'Exercice, Université de Lyon, F-42023 Saint-Etienne, France.
- The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2013 Nov;45(11):2444-55. doi: 10.1016/j.biocel.2013.07.019. Epub 2013 Aug 2.
- Administration of β2-agonists triggers skeletal muscle anabolism and hypertrophy. We investigated the time course of the molecular events responsible for rat skeletal muscle hypertrophy in response to 1, 3 and 10 days of formoterol administration (i.p. 2000μg/kg/day). A marked hypertrophy of rat t
- PMID 23916784
- Human Leptin Protein Induces Proliferation of A549 Cells via Inhibition of PKR-Like ER Kinase and Activating Transcription Factor-6 Mediated Apoptosis.
- Lai Q, Sun Y.SourceDepartment of Thoracic Surgery, General Hospital of Zaozhuang Mining Group, Qi lian shan Road 12, Shandong, Zaozhuang 277000, China. laiqunzz@yeah.net.
- Yonsei medical journal.Yonsei Med J.2013 Nov 1;54(6):1407-15. doi: 10.3349/ymj.2013.54.6.1407.
- Purpose: To investigate the anti-apoptotic mechanism of leptin in non-small cell lung cancer. Materials and Methods: The influences of leptin on apoptosis were investigated, analyzing the mechanism that triggers growth of A549 cells. The effects of leptin on cell proliferation were examined by XTT a
- PMID 24142645
Japanese Journal
- Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis
- Akazawa Yuko,Isomoto Hajime,Matsushima Kayoko,Kanda Tsutomu,Minami Hitomi,Yamaghchi Naoyuki,Taura Naota,Shiozawa Ken,Ohnita Ken,Takeshima Fuminao,Nakano Masayuki,Moss Joel,Hirayama Toshiya,Nakao Kazuhiko
- PLoS ONE 8(12), e82322, 2013-12-13
- … Phosphorylation of eukaryotic initiation factor 2 (eIF2)-alpha, which is known to occur downstream of the ER stress sensor PKR-like ERlocalized eIF2-alpha kinase (PERK) and to regulate CHOP expression, was also observed following incubation with VacA in the presence of ammonium chloride. …
- NAID 120005385428
- Cadmium induces ER stress and apoptosis in renal proximal tubular cells: protection by salubrinal
- KOMOIKE Yuta,MATSUOKA Masato
- 日本毒性学会学術年会 39.2(0), AP-32, 2012
- … Upon ER stress, double-stranded RNA-activated protein kinase-like ER kinase, an ER-resident transmembrane protein, oligomerizes and phosphorylates eukaryotic translation initiation factor 2 subunit α (eIF2α) at Ser51. … Salubrinal, a selective inhibitor of eIF2α dephosphorylation, has been shown to protect cells from ER stress-induced apoptosis. …
- NAID 130005009191
- Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models
- Miyashita Taishi,Toyoda Yasuyuki,Tsuneyama Koichi,Fukami Tatsuki,Nakajima Miki,Yokoi Tsuyoshi
- The Journal of Toxicological Sciences 37(5), 931-942, 2012
- … TAM increased the extracellular signal-regulated kinase (ERK) phosphorylation, which is related to the proliferation and regeneration of liver and to decreased DGAT2 gene expression. … Furthermore, a decrease in eukaryotic translational initiation factor (eIF2α), which is involved in apoptosis, was observed in both models. …
- NAID 130004447006
Related Links
- 1. Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Teske BF ...
- Article The EMBO Journal (2001) 20, 6909 - 6918 doi:10.1093/emboj/20.23.6909 Heme-regulated eIF2 kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency An-Ping Han 1, Channing Yu ...
Related Pictures
★リンクテーブル★
| リンク元 | 「真核生物翻訳開始因子2キナーゼ」「eIF2キナーゼ」 |
| 関連記事 | 「eIF2」「kinase」「eIF」 |
「真核生物翻訳開始因子2キナーゼ」
「eIF2キナーゼ」
「eIF2」
- 関
- eIF-2、eIF-2 alpha、eIF-2alpha、eukaryotic initiation factor-2、eukaryotic translation initiation factor 2
「kinase」
[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase