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Small molecule modulators of eukaryotic initiation factor 2α kinases, the key regulators of protein synthesis.

Joshi M, Kulkarni A, Pal JK.SourceBioinformatics Center, University of Pune, Pune - 411007, Maharashtra, India. Electronic address: manali@bioinfo.net.in.
Biochimie.Biochimie.2013 Nov;95(11):1980-90. doi: 10.1016/j.biochi.2013.07.030. Epub 2013 Aug 11.
Eukaryotic initiation factor 2 alpha kinases (eIF-2α kinases) are key mediators of stress response in cells. In mammalian cells, there are four eIF-2α kinases, namely HRI (Heme-Regulated Inhibitor), PKR (RNA-dependent Protein Kinase), PERK (PKR-like ER Kinase) and GCN2 (General Control Non-derepre
PMID 23939221

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.

Joassard OR, Amirouche A, Gallot YS, Desgeorges MM, Castells J, Durieux AC, Berthon P, Freyssenet DG.SourceLaboratoire de Physiologie de l'Exercice, Université de Lyon, F-42023 Saint-Etienne, France.
The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2013 Nov;45(11):2444-55. doi: 10.1016/j.biocel.2013.07.019. Epub 2013 Aug 2.
Administration of β2-agonists triggers skeletal muscle anabolism and hypertrophy. We investigated the time course of the molecular events responsible for rat skeletal muscle hypertrophy in response to 1, 3 and 10 days of formoterol administration (i.p. 2000μg/kg/day). A marked hypertrophy of rat t
PMID 23916784

Human Leptin Protein Induces Proliferation of A549 Cells via Inhibition of PKR-Like ER Kinase and Activating Transcription Factor-6 Mediated Apoptosis.

Lai Q, Sun Y.SourceDepartment of Thoracic Surgery, General Hospital of Zaozhuang Mining Group, Qi lian shan Road 12, Shandong, Zaozhuang 277000, China. laiqunzz@yeah.net.
Yonsei medical journal.Yonsei Med J.2013 Nov 1;54(6):1407-15. doi: 10.3349/ymj.2013.54.6.1407.
Purpose: To investigate the anti-apoptotic mechanism of leptin in non-small cell lung cancer. Materials and Methods: The influences of leptin on apoptosis were investigated, analyzing the mechanism that triggers growth of A549 cells. The effects of leptin on cell proliferation were examined by XTT a
PMID 24142645

Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis

Akazawa Yuko,Isomoto Hajime,Matsushima Kayoko,Kanda Tsutomu,Minami Hitomi,Yamaghchi Naoyuki,Taura Naota,Shiozawa Ken,Ohnita Ken,Takeshima Fuminao,Nakano Masayuki,Moss Joel,Hirayama Toshiya,Nakao Kazuhiko
PLoS ONE 8(12), e82322, 2013-12-13
… Phosphorylation of eukaryotic initiation factor 2 (eIF2)-alpha, which is known to occur downstream of the ER stress sensor PKR-like ERlocalized eIF2-alpha kinase (PERK) and to regulate CHOP expression, was also observed following incubation with VacA in the presence of ammonium chloride. …
NAID 120005385428

Cadmium induces ER stress and apoptosis in renal proximal tubular cells: protection by salubrinal

KOMOIKE Yuta,MATSUOKA Masato
日本毒性学会学術年会 39.2(0), AP-32, 2012
… Upon ER stress, double-stranded RNA-activated protein kinase-like ER kinase, an ER-resident transmembrane protein, oligomerizes and phosphorylates eukaryotic translation initiation factor 2 subunit α (eIF2α) at Ser51. … Salubrinal, a selective inhibitor of eIF2α dephosphorylation, has been shown to protect cells from ER stress-induced apoptosis. …
NAID 130005009191

Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models

Miyashita Taishi,Toyoda Yasuyuki,Tsuneyama Koichi,Fukami Tatsuki,Nakajima Miki,Yokoi Tsuyoshi
The Journal of Toxicological Sciences 37(5), 931-942, 2012
… TAM increased the extracellular signal-regulated kinase (ERK) phosphorylation, which is related to the proliferation and regeneration of liver and to decreased DGAT2 gene expression. … Furthermore, a decrease in eukaryotic translational initiation factor (eIF2α), which is involved in apoptosis, was observed in both models. …
NAID 130004447006