骨髄異形成症候群
- 関
- MDS、myelodysplastic syndrome
WordNet
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
PrepTutorEJDIC
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
UpToDate Contents
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English Journal
- E-Cadherin Is a Specific Marker for Erythroid Differentiation and Has Utility, in Combination With CD117 and CD34, for Enumerating Myeloblasts in Hematopoietic Neoplasms.
- Ohgami RS1, Chisholm KM, Ma L, Arber DA.Author information 1Dept of Pathology, Stanford University Medical Center, 300 Pasteur Dr, Rm L235, Stanford, CA 94305; rohgami@stanford.edu.AbstractObjectives E-cadherin, epithelial calcium-dependent cell adhesion protein, has been identified as a marker of immature erythroid precursors in recent years. However, the specificity of E-cadherin in bone marrow specimens for erythroblasts vs myeloblasts or other early hematopoietic precursors in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has not been fully elucidated. Methods We analyzed 105 cases of AML and MDS to evaluate the specificity of E-cadherin. Results Of 84 cases of AML, including cases with megakaryocytic, erythroid, monocytic, and granulocytic differentiation, all five acute erythroleukemia cases were positive, as well as one case of megakaryoblastic leukemia that showed coexpression of glycophorin A. In addition, we demonstrate that a panel of three markers, E-cadherin, CD117, and CD34, is effective in identifying lineage-specific myeloblasts in cases of MDS where left-shifted erythroid hyperplasia may complicate morphologic assessment of myeloblasts. Conclusions In marrow specimens, E-cadherin is a useful marker for erythroid differentation.
- American journal of clinical pathology.Am J Clin Pathol.2014 May;141(5):656-64. doi: 10.1309/AJCP8M4QQTAZPGRP.
- Objectives E-cadherin, epithelial calcium-dependent cell adhesion protein, has been identified as a marker of immature erythroid precursors in recent years. However, the specificity of E-cadherin in bone marrow specimens for erythroblasts vs myeloblasts or other early hematopoietic precursors in acu
- PMID 24713736
- Real-life experience with azacitidine in myelodysplastic syndromes according to IPSS cytogenetic profile.
- Breccia M1, Voso MT, Maurillo L, Niscola P, Fianchi L, Aloe Spiriti MA, Buccisano F, Latagliata R, Pelliccia S, Fenu S, Tendas A, Alimena G.
- American journal of hematology.Am J Hematol.2014 May;89(5):565. doi: 10.1002/ajh.23677. Epub 2014 Feb 28.
- PMID 24458879
- Impact of comorbidities by ACE-27 in the revised-IPSS for patients with myelodysplastic syndromes.
- Daver N1, Naqvi K, Jabbour E, Kadia T, Dinardo C, Cardenas-Turanzas M, Pierce S, Nguyen KT, Bueso-Ramos C, Kantarjian H, Garcia-Manero G.Author information 1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.AbstractComorbidities significantly affect the prognosis and outcomes of patients with hematological malignancies. We have previously reported the impact of comorbidities on the International Prognostic Scoring System (IPSS) score. The aim of this study was to determine whether comorbidities continued to have a significant impact when patients were reclassified according to the Revised-IPSS (IPSS-R). The medical records of 600 consecutive myelodysplastic syndrome patients who presented to MD Anderson Cancer Center between January 2002 and June 2004 were reviewed. The Adult Comorbidity Evaluation-27 (ACE-27) was used to assess the severity of comorbid conditions. Four hundred and two (67%) patients were male. Median age at presentation was 66.6 years (17-94). Mean duration of follow-up was 54 months (1-100). Five hundred and two (84%) patients died, and 54 (9%) patients underwent stem cell transplantation. Overall median survival was 16.8 months (1-100). Median survival by IPSS-R was 47, 34, 21, 16, and 6 months for patients in very low, low, intermediate, high, and very high-risk groups, respectively (P < 0.001). The ACE-27 comorbidity score significantly impacted the median survival of patients in the intermediate (P < 0.001), high (P = 0.045), and very high (P = 0.004) IPSS-R groups; but did not significantly impact the median survival in the low (P = 0.11) and very low (P = 0.49) IPSS-R groups. The ACE-27 comorbidity score significantly impacted the median survival of patients ≤65 years (P < 0.001) but did not significantly impact those >65 years (P = 0.18). Assessment of comorbidity may enhance the prognostic ability of the IPSS-R. Am. J. Hematol. 89:509-516, 2014. © 2014 Wiley Periodicals, Inc.
- American journal of hematology.Am J Hematol.2014 May;89(5):509-16. doi: 10.1002/ajh.23675. Epub 2014 Feb 21.
- Comorbidities significantly affect the prognosis and outcomes of patients with hematological malignancies. We have previously reported the impact of comorbidities on the International Prognostic Scoring System (IPSS) score. The aim of this study was to determine whether comorbidities continued to ha
- PMID 24458781
Japanese Journal
- Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities.
- Dysmyelopoietic Syndromeの臨床経過,特に蛋白同化ステロイドの影響について
- いわゆるdysmyelopoietic syndromeのin vitroコロニ-(CFU-cおよびCFU-e)形成とその病態 (Hemopoietic Dysplasia(第20回日本臨床血液学会総会円卓討議)) -- (CFU-c)
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