薬物送達、ドラッグデリバリー

WordNet

utter (an exclamation, noise, etc.); "The students delivered a cry of joy"
carry out or perform; "deliver an attack", "deliver a blow"; "The boxer drove home a solid left" (同)drive_home
throw or hurl from the mound to the batter, as in baseball; "The pitcher delivered the ball" (同)pitch
deliver (a speech, oration, or idea); "The commencement speaker presented a forceful speech that impressed the students" (同)present
save from sins (同)redeem, save
bring to a destination, make a delivery; "our local super market delivers"
the act of delivering or distributing something (as goods or mail); "his reluctant delivery of bad news" (同)bringing
the voluntary transfer of something (title or possession) from one party to another (同)livery, legal transfer
the act of delivering a child (同)obstetrical delivery
the event of giving birth; "she had a difficult delivery"
use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic

PrepTutorEJDIC

(人・場所に)〈手紙・荷物など〉'を'『配達する』,届ける;〈伝言など〉'を'伝える《+『名』+『to』+『名』》 / (…に)〈打撃・攻撃など〉'を'『加える』;〈球〉'を'投げる《+『名』+『to』+『名』》 / 〈意見など〉'を'『述べる』,〈判決など〉'を'申し渡す / (…から)〈人〉'を'『朽う』,解放する《+『名』+『from』+『名』》 / (…に)…'を'引き渡す《+『名』+『to』+『名』》 / 〈子〉'を'分娩(ぶんべん)させる;〈妊婦〉‘に'分娩させる
〈U〉〈C〉(…への)(手紙・荷物などの)『配達』,便;配達品《+『for』+『名』》 / 〈U〉《文》(…からの)釈放,解放《+『from』+『名』》 / 〈U〉〈C〉分娩(ぶんべん),出産 / 〈U〉〈C〉話しぶり,弁舌 / 〈U〉(野球の)投球[ぶり],(テニスなどの)打ち方
『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/29 13:31:30」(JST)

wiki en

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect.^[1] It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.^[2]

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms.^[3] Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes.^[4]^[5] Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action.^[6] Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

References

M. N. V. Ravi Kumar (2008), Handbook of Particulate Drug Delivery (2-Volume Set), American Scientific Publishers. ISBN 1-58883-123-X

^ http://www.reference.md/files/D016/mD016503.html
^ http://medical-dictionary.thefreedictionary.com/drug+delivery
^ Wang, NX.; von Recum, HA (2011). "Affinity-Based Drug Delivery". Macromol Biosci 11: 321–332. doi:10.1002/mabi.201000206.
^ "Definition". Retrieved 2008-05-27.
^ "Definition". Retrieved 2008-05-27. ^{[dead link]}
^ Bertrand N, Leroux JC. (2011). "The journey of a drug carrier in the body: an anatomo-physiological perspective". Journal of Controlled Release 161 (2): 152–63. doi:10.1016/j.jconrel.2011.09.098. PMID 22001607.

External links

Article in Chemical and Engineering News

UpToDate Contents

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1. 早産リスクのある女性における出産前のステロイドの使用 antenatal use of corticosteroids in women at risk for preterm delivery
2. 陣痛および分娩に対する硬膜外・脊椎麻酔：薬 neuraxial analgesia and anesthesia for labor and delivery drugs
3. 陣痛および出産への備え preparation for labor and childbirth
4. 出産センター birth centers
5. 妊娠中および授乳中のリウマチ性疾患における抗炎症剤および免疫抑制剤の使用 use of antiinflammatory and immunosuppressive drugs in rheumatic diseases during pregnancy and lactation

English Journal

Biocompatible and target specific hydrophobically modified glycol chitosan nanoparticles.

Yin W1, Li W2, Rubenstein DA3, Meng Y2.
Biointerphases.Biointerphases.2016 Dec 28;11(4):04B301. doi: 10.1116/1.4948265.
Cardiovascular disease is the leading cause of death in the United States. Atherosclerosis is a major cause for cardiovascular diseases. Drugs that treat atherosclerosis usually act nonspecifically. To enhance drug delivery specificity, the authors developed a hydrophobically modified glycol chitosa
PMID 27126597

Role of pH-responsiveness in the design of chitosan-based cancer nanotherapeutics: A review.

Suarato G1, Li W1, Meng Y1.
Biointerphases.Biointerphases.2016 Dec 25;11(4):04B201. doi: 10.1116/1.4944661.
There is a continuous demand for sensitive and efficient cancer drug delivery systems that, when administered at low concentrations, are capable of detecting early-stage pathological conditions and increasing patient survival without adverse side effects. Recent developments in the design of chitosa
PMID 27016506

Lateral flow based immunobiosensors for detection of food contaminants.

Raeisossadati MJ1, Danesh NM2, Borna F3, Gholamzad M4, Ramezani M5, Abnous K6, Taghdisi SM7.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Dec 15;86:235-46. doi: 10.1016/j.bios.2016.06.061. Epub 2016 Jun 21.
Safety of food is of great concern these days due to various contaminations including toxins, infectious agents and chemical contaminants. Therefore, there is a need to develop promising and user's friendly method to monitor food safety. Lateral flow tests are new, simple and rapid alternative for d
PMID 27376194

Japanese Journal

S/O技術を利用した経皮薬物送達システム (特集エマルションの新しい潮流)

後藤雅宏
オレオサイエンス 12(8), 327-331, 2012-08
NAID 40019395753

Mitochondrial-targeted DNA delivery using a DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes

Yamada Yuma,Kawamura Eriko,Harashima Hideyoshi
Journal of Nanoparticle Research 14(8), 1013, 2012-08
… A number of mitochondrial drug delivery systems have been reported to date. … However, reports of mitochondrial-targeted DNA delivery are limited. … We report herein on the mitochondrial delivery of oligo DNA as a model therapeutic using a Dual Function (DF)-MITO-Porter, an innovative nano carrier designed for mitochondrial delivery. …
NAID 120004689034