遠位直尿細管
WordNet
- not homosexual
- a poker hand with 5 consecutive cards (regardless of suit)
- successive (without a break); "sick for five straight days" (同)consecutive
- characterized by honesty and fairness; "straight dealing"; "a square deal" (同)square
- erect in posture; "sit straight"; "stood defiantly with unbowed back" (同)unbent, unbowed
- (of hair) having no waves or curls; "her naturally straight hair hung long and silky"
- following a correct or logical method; "straight reasoning"
- free from curves or angles; "a straight line"
- having no deviations; "straight lines"; "straight roads across the desert"; "straight teeth"; "straight shoulders"
- in a straight line; in a direct course; "the road runs straight"
- in keeping with the facts; "set the record straight"; "made sure the facts were straight in the report"
- neatly arranged; not disorderly; "the room is straight now"
- situated farthest from point of attachment or origin, as of a limb or bone
- directed away from the midline or mesial plane of the body
- a small tube
PrepTutorEJDIC
- 『まっすぐな』,一直線の / (毛髪などが)まっすぐな / (背などが,曲らずに)『直立した』,まっすぐな / 《補語にのみ用いて》『整理した』,きちんとした / 真実を言う,率直な,正直な / 連続した / 《米》(ある政党に)徹底した,ベッタリの,きっすいの / (比較変化なし)『まっすぐに』,一直線に;『直立して』,垂直に / 『直ちに』,回り道をしないで / 率直に,端的に / 《the~》まっすぐ,一直線;直線コース / (カードゲームで)ポーカーの5枚続き,ストレート
- 中心から遠い,末梢(まっしょう)[部]の,末端[部]の
- 小管,細管
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/23 06:43:05」(JST)
[Wiki en表示]
| Ascending limb of loop of henil |
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Scheme of renal tubule and its vascular supply. (Labeled at center left.)
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Nephron ion flow diagram
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| Details |
| Latin |
tubulus rectus distalis, pars recta tubuli distalis |
| Identifiers |
| Gray's |
p.1223 |
Dorlands
/Elsevier |
t_22/12830078 |
| FMA |
17717 |
| Anatomical terminology |
The ascending limb of loop of Henle is a segment of the nephron in the kidney divided into a thin and thick ascending limb (also known as distal straight tubule).
Contents
- 1 Structure
- 2 Function
- 2.1 Thin ascending limb
- 2.2 Thick ascending limb
- 3 Clinical significance
- 4 See also
- 5 References
- 6 External links
Structure
The ascending limb of the loop of Henle is a direct continuation from the descending limb of loop of Henle, and one of the structures in the nephron of the kidney. The ascending limb has a thin and a thick segment. The ascending limb drains urine into the distal convoluted tubule.
The thin ascending limb is found in the medulla of the kidney, and the thick ascending limb can be divided into a part that is in the renal medulla and a part that is in the renal cortex. The ascending limb is much thicker than the descending limb.
Histology
As in the descending limb, the epithelium is simple squamous epithelium. [1]
Function
Thin ascending limb
The thin ascending limb is impermeable to water and ions, except sodium and chloride which cross by diffusion.
Thick ascending limb
Functionally, the parts of the ascending limb in the medulla and cortex are very similar.[citation needed]
The medullary ascending limb remains impermeable to water. Sodium (Na+), potassium (K+) and chloride (Cl−) ions are reabsorbed by active transport. K+ is passively transported along its concentration gradient through a K+ leak channel in the apical aspect of the cells, back into the lumen of the ascending limb. This K+ "leak" generates a positive electrochemical potential difference in the lumen. This drives more paracellular reabsorption of Na+, as well as other cations such as magnesium (Mg2+) and importantly calcium Ca2+ due to charge repulsion.
This is also the part of the tubule that generates Tamm-Horsfall protein. The function of this protein is not well understood, but is responsible for creating urinary casts.
Clinical significance
The thick ascending limb is the site of action of Loop diuretics such as furosemide block the K+/Na+/2Cl− co-transporter.
See also
- Descending limb of loop of Henle
References
This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)
- ^ Pawlina, Wojciech and Ross, Michael. Histology: A text and Atlas. 5th ed. N.p: Clipping,2006. 663+.Print.
External links
- Physiology: 7/7ch07/7ch07p11 - Essentials of Human Physiology
- Histology image: 15804loa – Histology Learning System at Boston University
- Overview at vet.cornell.edu
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Anatomy of the urinary system
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| Kidneys |
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Layers
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- Fascia
- Capsule
- Cortex
- Medulla
- sinus
- pyramids
- medullary interstitium
- Lobe
- Cortical lobule
- Medullary ray
- Nephron
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Circulation
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- Arteries
- Renal artery
- segmental
- interlobar
- arcuate
- interlobular
- afferent
- Veins
- Renal vein
- Peritubular capillaries
- Vasa recta
- arcuate
- interlobar
- efferent
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Nephron
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Renal corpuscle
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- Glomerulus
- Bowman's capsule
- Glomerular basement membrane
- Podocyte
- Filtration slits
- Mesangium
- Intraglomerular mesangial cell
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Renal tubule
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- Proximal convoluted tubule
- Loop of Henle
- Descending
- Thin ascending
- Thick ascending
- Distal convoluted tubule
- Connecting tubule
- Tubular fluid
- Renal papilla
- Minor calyx
- Major calyx
- Renal pelvis
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Juxtaglomerular apparatus
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- Macula densa
- Juxtaglomerular cells
- Mesangium
- Extraglomerular mesangial cell
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| Ureters |
- Orifice of ureter
- Ureteropelvic junction
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| Bladder |
- Apex
- Uvula
- Neck
- Median umbilical ligament
- Muscular layer
- Mucosa
- Submucosa
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| Urethra |
- Urethral sphincters
- External sphincter
- Internal sphincter
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Index of the urinary system
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| Description |
- Anatomy
- Physiology
- Development
- Cells
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| Disease |
- Electrolyte and acid-base
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
- Urine tests
- Blood tests
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| Treatment |
- Procedures
- Drugs
- Intravenous fluids
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UpToDate Contents
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English Journal
- Morphological and molecular investigations of the holocephalan elephant fish nephron: the existence of a countercurrent-like configuration and two separate diluting segments in the distal tubule.
- Kakumura K1,2, Takabe S3, Takagi W3, Hasegawa K3, Konno N4, Bell JD5, Toop T6, Donald JA6, Kaneko T7, Hyodo S3.
- Cell and tissue research.Cell Tissue Res.2015 Dec;362(3):677-88. doi: 10.1007/s00441-015-2234-4. Epub 2015 Jul 17.
- In marine cartilaginous fish, reabsorption of filtered urea by the kidney is essential for retaining a large amount of urea in their body. However, the mechanism for urea reabsorption is poorly understood due to the complexity of the kidney. To address this problem, we focused on elephant fish (Call
- PMID 26183720
- The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish.
- Zhang J1, Yuan S1, Vasilyev A2, Amin Arnaout M3.
- Mechanisms of development.Mech Dev.2015 Nov;138P3:328-335. doi: 10.1016/j.mod.2015.08.001. Epub 2015 Aug 4.
- The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight tubule (PST) segments. The distal segment consists of the distal-early (DE) and distal-late (DL) se
- PMID 26248207
- A mathematical model of the rat nephron: glucose transport.
- Weinstein AM1.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 May 15;308(10):F1098-118. doi: 10.1152/ajprenal.00505.2014. Epub 2015 Feb 18.
- Mathematical models of the proximal tubule (PT), loop of Henle (LOH), and distal nephron have been combined to simulate transport by rat renal tubules. The ensemble is composed of 24,000 superficial (SF) nephrons and 12,000 juxtamedullary (JM) nephrons in 5 classes (according to LOH length); all coa
- PMID 25694480
Japanese Journal
- Localization of Calcitonin Receptor mRNA in Rat Kidney : an In Situ Hybridization Study
- Ishii Aiko,Nakamura Misa,Nakamura Atsushi,Kimura Masaaki,Kakudo Kennichi
- Acta histochemica et cytochemica = Official Journal of the Japan Society of Histochemistry and Cytochemistry 37(4), 259-265, 2004
- … The intense signal was observed in the straight tubule of the cortex and the outer stripe of the outer medulla, but not in the inner medulla. … A less intense signal was observed in the convoluted and collecting tubules, glomeruli, and renal tubule of the inner stripe of the outer medulla. … Although CTR expression in the proximal straight tubule was suggested based on the physiological evidence, CTR localization was not proven. …
- NAID 110003144387
- Nephron Distribution of Total Low Km Cyclic AMP Phosphodiesterase in Mouse, Rat and Rabbit Kidney.
- Kusano Eiji,Yoshida Izumi,Takeda Shigeyuki,Homma Sumiko,Yusufi Ahad N.K.,Dousa Thomas P.,Asano Yasushi
- The Tohoku Journal of Experimental Medicine 193(3), 207-220, 2001
- … We assayed total low Km cAMP PDE in microdissected tubule segments, using 10−6 M (3H)-cAMP as a substrate. … Proximal convoluted tubule, proximal straight tubule, medullary thick ascending limb of Henle's loop (mTAL), and outer medullary collecting duct (OMCD) had intermediated activity. …
- NAID 130004459103
- 腎におけるＬ‐セレクチンリガンドの発現とその白血球浸潤への関与
- 川島 博人,李 永菲,宮坂 昌之
- 炎症 18(6), 419-424, 1998
- … Immuno-precipitation analysis with LEC-IgG revealed that a proteoglycan-like molecule from a renal tubule-derived cell line specifically bound to L-selectin. … Histochemical examination confirmed that versican is localized in the distal straight tubules of the rat kidney where L-selectin ligands are detected. …
- NAID 130003856490
★リンクテーブル★
[★]
- 英
- distal straight tubule, DST
- 関
- 遠位尿細管
[★]
- 関
- centrifugal、distalis、distally、distant、efferent、end、extremity、terminal、terminally
[★]
- 関
- canaliculi、canaliculus、kidney tubule、renal tubular、renal tubule、tubular、uriniferous tubule
[★]
- 関
- linear、normal