関: disease tolerance、innate immunity、natural immunity、natural resistance

WordNet

any mechanical force that tends to retard or oppose motion
the capacity of an organism to defend itself against harmful environmental agents; "these trees are widely planted because of their resistance to salt and smog"
the action of opposing something that you disapprove or disagree with; "he encountered a general feeling of resistance from many citizens"; "despite opposition from the newspapers he went ahead" (同)opposition
(psychiatry) an unwillingness to bring repressed feelings into conscious awareness
group action in opposition to those in power
the military action of resisting the enemys advance; "the enemy offered little resistance"
the degree of unresponsiveness of a disease-causing microorganism to antibiotics or other drugs (as in penicillin-resistant bacteria)
an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

〈U〉〈C〉(…に)『抵抗』(『反抗』)『すること』;(…を)『こらえること』《+『to』(『against』)+『名』(do『ing』)》 / 〈U〉(病気などに対する)『抵抗力』《+『against』(『to』)+『名』》 / 〈U〉〈C〉(またresistance movement)(権力・圧制に対する)抵抗運動,レジスタンス / 〈U〉(空気の)抵抗;(電気の)抵抗
(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/30 11:21:23」(JST)

wiki en

There are a number of lines of defence against pests (that, those animals that cause damage to the plants we grow) and diseases in the O, principal among these being the practice of good husbandry, creating healthy soil and ensuring high standards of garden hygiene. But no matter how diverse and healthy the garden eco-system may be, there will always be a degree of disease and pest presence. In many ways, some level of pathogen population in the garden can be not only acceptable but desirable as they are indicative of a generally healthful and diverse environment, and add to the overall robustness of the system as an immunity to such detrimental influences will build up, particularly in a balanced polycultural regime. Indeed, most of the plants we grow will tend to be selected because they are trouble free, and those that are more susceptible to attack will have fallen by the wayside over time. However, most farmers find it unacceptable that the food crops they grow are damaged by pests.

For these crops there has been considerable research and selective breeding carried out in order to find cultivars that are resistant or immune to pest and disease damage. Breeding for plant disease resistance generally has involved finding suitable genetic material amongst existing stocks or in the wild, which is then incorporated into commercial varieties.

Example: The apple

In the case of apples, in which research is being carried out in order to develop resistance to diseases such as apple scab (Venturia inaequalis), powdery mildew (Podosphaera leucotricha), orchard fireblight (Erwinia amylovora), woolly apple aphid (Eriosoma lanigerum) and collar rot (Phytophthora cactorum), the main sources of resistant material used in breeding programmes such as those being run by East Malling Research Station in England or Hortresearch in New Zealand are major gene resistances derived from crab-apples. The Vf gene for black spot resistance^{[citation needed]} is derived from the ornamental crab-apple species Malus floribunda. Most black spot resistant cultivars developed around the world carry this gene, but there are some selections that carry the Vr (from M. pumila) or Vm (from M. micromalus) gene. Major gene resistances to powdery mildew are derived from M. robusta (Pl1) and M. zumi (Pl2), and the apple cultivar Northern Spy has a long-standing reputation for its major gene resistance to woolly apple aphid. Since early this century this resistance has been used to develop woolly aphid resistant rootstocks such as MM.106 and M.793. Much later it was shown that the cultivar was also very resistant to collar rot and a useful breeding parent for this resistance.

Resistance and immunity

Some plants can tolerate the presence of large numbers of insects without being severely affected. This is not very satisfactory however as insects will still cause damage, and in fact further breeding and population expansion of the pest species is supported. Other varieties are less attractive to pests, but this can be difficult to sustain or demonstrate.
The most valuable form of resistance is where the pest cannot survive as well on one variety as on another. In some cases this can actually make the plants immune to attack, as is the case with the lettuces Avoncrisp and Avondefiance which were bred at the Institute of Horticultural Research, Wellesbourne during the 1960s, which are fully resistant to lettuce root aphid (Pemphigus bursarius).

Trade-off of breeding for resistance

Sometimes however there can be a trade-off, for those varieties which have increased immunity or resistance may be lacking in other qualities such as flavour, yield or quality. Celery resistant to the Fusarium fungus (Fusarium oxysporum spp.) may not succumb to this disease, but may also be unacceptably short, ribby and low yielding.
Further, a cultivar that is resistant to one disease may be more susceptible to another that is equally important. A lettuce cultivar that is resistant to mosaic virus may be sensitive to corky root disease, whilst another that resists corky root may be vulnerable to downy mildew (Brim lactic).
Another drawback to resistance is that depending on the host pathogen system, resistance is sometimes not long lasting as new pathogen strains quickly develop, and further research and breeding is constantly needed.

Availability of resistant varieties

Resistant varieties are not available for all crops. For several of the most damaging plant diseases, such as Potato blight (Phytophthora infestans) and white rot (Sclerotic cepivorum) of the Allium family, no acceptable resistant cultivars are yet available. In addition, commercial seed companies and plant breeders rarely invest resources into developing resistant cultivars for more minor or speciality crops, which often tend to be those of greater interest to the organic grower.

In general it is probably fair to say that resistance will not fully guarantee total crop protection, but choosing resistant varieties should rather be considered as a part of an overall Integrated pest management strategy, especially against virus diseases. In particular they can be especially useful where the threat from specific pests and diseases is high.

Table of resistant crops

The table below illustrates a number of pest and disease resistant vegetable crop varieties, although should not be considered comprehensive.

Crop	Variety	Comments
French Bean	Aigullion	Resistant to bean mosaic virus and anthracnose
	Hildora	Tolerant of bean mosaic virus
	Maxi	Tolerant of bean mosaic virus
	Nektar Queen	Resistant to bean mosaic virus
	Farba	Resistant to bean mosaic virus
	Hilda	Resistant to bean mosaic virus
Broad Bean	Futura	Tolerant of chocolate spot
Brussels sprouts	Cavalier	Resistant to light leaf spot
	Braveheart F1	Resistant to powdery mildew and light leaf spot
Cabbage	Stonehead F1	Resistant to mildew
Calabrese	Emperor F1	Highly tolerant of black rot and downy mildew
	Sampson F1	Highly resistant to black rot and downy mildew
Carrot	Fly Away F1	Bred for resistance to carrot fly
	Newmarket	Good resistance to splitting
Cucumber	Bush Champion F1	Resistant to cucumber mosaic virus
	Marketmore	Resistant to cucumber mosaic virus
	Burpless Tasty Green F1	Resistant to mildew and tolerant of heat
	Slice King F1	Resistant to downy and powdery mildew, gummosis and angular leaf spot
	Cumlaude F1	Tolerant of powdery mildew
	Media F1	Tolerant of powdery mildew
Leek	Swiss Giant, Zermatt	Moderate rust resistance
	Alvitta	Rust Tolerant
	Conora	Good resistance to rust
Lettuce	Alexandria	Highly resistant to downy mildew and bolting
	Lisbusa	Resistant to downy mildew, tolerant of mosaic virus, root aphid and tipburn
	Sylvestra	Resistant to downy mildew and aphids
	Little Gem	Resistant to root aphid
	Barcelona	Resistant to aphids and mildew
	Iglo	Resistant to downey mildew
	Revolution	Resistant to mildew and bolting
	Smile	Resistant to aphids, mildew, tipburn and bolting
Parsnip	Avonreister	Very good resistance to canker
	Gladiator F1	High resistance to canker
	Tender and True	Good canker resistance
Pea	Ambassador	Resistant to powdery mildew, entation virus and fusarium wilt
	Cavalier	Good resistance to powdery mildew.
	Greenshaft	Resistant to downy mildew and fusarium wilt
	Rondo	Resistant to fusarium wilt
Potato (first early)	Colleen	Good resistance to blight and scab
	Premiere	Resistant to blight and spraing
	Pentland Javelin	Good all round disease resistance, including golden eelworm and scab
	Swift	Resistant to golden eelworm and tolerant to blackleg
Potato (second early)	Cosmos	Resistant to blight and common scab
	Osprey	Very resistant to scab and eelworm
Potato (maincrop)	Harmony	Very resistant to scab and partially resistant to white and golden eelworm
	Milva	Blight resistant
	Remarka	Good all around disease resistance
	Admiral	Good resistance to blight and scab
	Cara	Blight resistant
	Valor	Good overall disease resistance combined with high eelworm and blight resistance
Pepper	Bell Boy F1	Mosaic virus resistant
	Mandy F1	Highly resistant to mosaic virus
Sweetcorn	Golden sweet F1	Highly resistant to smut
Tomato	Alicante	Good resistance to greenback and mildew
	Libra F1	Resistant to fusarium crown and root rot
	Shirley F1	Resistant to fusarium, cladosporium and TMV

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We report the sensitive detection of C-reactive protein (CRP), a biomarker for cardiac disease, using a carbon nanofiber based biosensor platform. Vertically aligned carbon nanofibers were grown using plasma enhanced chemical vapor deposition to fabricate nanoelectrode arrays in a 3×3 configuration
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γ-Aminobutyric acid induces resistance against Penicillium expansum by priming of defence responses in pear fruit.

Yu C1, Zeng L1, Sheng K1, Chen F1, Zhou T1, Zheng X1, Yu T2.
Food chemistry.Food Chem.2014 Sep 15;159:29-37. doi: 10.1016/j.foodchem.2014.03.011. Epub 2014 Mar 13.
The results from this study showed that treatment with γ-aminobutyric acid (GABA), at 100-1000μg/ml, induced strong resistance against blue mould rot caused by Penicillium expansum in pear fruit. Moreover, the activities of five defence-related enzymes (including chitinase, β-1,3-glucanase, pheny
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Biocide and antibiotic susceptibility of Salmonella isolates obtained before and after cleaning at six Danish pig slaughterhouses.

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Japanese Journal

アレルギー性結膜疾患の治療

高村悦子
東京女子医科大学雑誌 82(E1), E8-E14, 2012-01-31
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Clinical Characteristics of Tertiary Hospital Patients from Whom Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Strains were Isolated

Yamada Koichi,Yanagihara Katsunori,Araki Nobuko,Harada Yosuke,Morinaga Yoshitomo,Akamatsu Norihiko,Matsuda Junichi,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Hasegawa Hiroo,Kohno Shigeru,Kamihira Shimeru
Internal Medicine 51(1), 51-57, 2012-01-01
… Risk factors for Acb complex infection include being over 60 years of age, chronic liver disease, and the use of firstgeneration cephalosporins prior to isolation. … The appropriate usage of antibiotics should be continued for the prevention of drug resistance in Acb complex. …
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Pulmonary hypertension associated with veno-occlusive disease in systemic sclerosis: Insight into the mechanism of resistance to vasodilator

Tada Hayato,Konno Tetsuo,Aizu Motohiko,Yokawa Junichiro,Tsubokawa Toshinari,Fujii Hiroshi,Hayashi Kenshi,Uchiyama Katsuharu,Matsumura Masami,Kawano Mitsuhiro,Kawashiri Masa-aki,Yamagishi Masakazu
Journal of Cardiology Cases xx(xx), xxxx-xxxx, 2012
… We report a case with pulmonary veno-occlusive disease (PVOD) associated with systemic sclerosis which exhibits strong resistance to pulmonary vasodilator. … We suggest that prevalence of veno-occlusive type of disease could be one of the major mechanisms of less responsive or even refractory to pulmonary vasodilator therapies in patients with PAH associated with connective tissue disease. …
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