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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/30 16:23:45」(JST)

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Difluocortolone valerate (also Nerisone cream/oily cream/ointment, Neriderm ointment, Japanese ジフルコルトロン (Jifurucorutoron^?) is a corticosteroid rated Class 2 "potent" (100-150 times) in the New Zealand topical steroid system. Chemically, it is a corticosteroid esterified with valeric acid. It is commonly used topically in dermatology. The brand name is Nerisone; its creams come in potencies of 0.1% and 0.3%.

References

^ Chemlink Diflucortolone valerate

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English Journal

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations.

Eroğlu I1, Azizoğlu E, Ozyazıcı M, Nenni M, Gürer Orhan H, Ozbal S, Tekmen I, Ertam I, Unal I, Ozer O.
Drug delivery.Drug Deliv.2014 Sep 26:1-12. [Epub ahead of print]
Abstract Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal
PMID 25259424

Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate - a case report & review of the literature.

Haviv R1, Capua M2, Amir J1, Harel L1.
Pediatric rheumatology online journal.Pediatr Rheumatol Online J.2014 Oct 10;12:46. doi: 10.1186/1546-0096-12-46. eCollection 2014.
Cutaneous Polyarteritis Nodosa (cPAN) was first described in 1931. cPAN is considered a rare disease, its true incidence is unknown. The age of onset is diverse. Most studies have shown no significant gender predominance. cPAN presents with distinct skin findings, such as a maculopapular rash, subcu
PMID 25328491

Rapid relief of intertrigo-associated pruritus due to Candida albicans with isoconazole nitrate and diflucortolone valerate combination therapy.

Veraldi S.
Mycoses.Mycoses.2013 May;56 Suppl 1:41-3. doi: 10.1111/myc.12058.
A 43-year-old male, with intertrigo due to Candida albicans located at the inguinal folds and accompanied by severe pruritus, was treated with topical 1% isoconazole nitrate and 0.1% diflucortolone valerate (2 applications/day for 7 days). An improvement of pruritus was reported 2 days after the beg
PMID 23574026

Japanese Journal

尋常性乾癬に対する活性型ビタミンD_3軟膏治療における吉草酸ジフルコルトロン軟膏の併用効果

戸倉新樹,森智子,伊豆邦夫,瀧川雅浩
西日本皮膚科 = The Nishinihon journal of dermatology 66(2), 188-191, 2004-04-01
NAID 10019000514

合成副腎皮質ステロイドMethylprednisolone aceponateの抗炎症作用

生駒幸弘 [他],山下雅世,紙谷清,中川英彦
日本薬理学雑誌 98(5), 409-417, 1991
… In the case of dermal application of the drugs to croton oil-induced ear edema in rats and picryl chlorideinduced delayed type hypersensitivity in mice, the anti-inflammatory effect of methylprednisolone aceponate (MPA) was slightly weaker than those of clobetasol 17-propionate and diflucortolone 21-valerate, but stronger than those of hydrocortisone 17-butyrate and hydrocortisone 17-butyrate 21propionate. …
NAID 130000758814

高速液体クロマトグラフィーによる軟こう中の副じん皮質ホルモン及びパラベンの同時定量

前田有美恵 [他],小和田和宏,山本政利,佐野智子,増井俊夫,中澤裕之
分析化学 37(12), 648-653, 1988-12-05
HPLCにより,軟こう中の11種類の副じん皮質ホルモン及び4種類のパラベンを一斉分析する方法を確立した.試料の前処理として,軟こう中の基剤を除去するためにディスポーザブルのSep-Pakシリカゲルカートリッジを用いたクリーンアップを行った.HPLCの条件は,カラム:Inertsil ODS-2,移動相:水/メタノール系,検出波長:UV 240nm(副じん皮質ホルモンの極大吸収付近)とそれぞれ設定す …
NAID 110002909751

「ジフルコルトロン」

Difluocortolone valerate
	IUPAC name (6α,11β,16α)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
	Other names Afusona; Diflucortolone 21-valerate
Identifiers
CAS number	59198-70-8
PubChem	91670
ChemSpider	82773
ChEMBL	CHEMBL65702
Jmol-3D images	Image 1
	SMILES O=C(OCC(=O)[C@@H]3[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C)CCCC ;
	InChI InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 ; Key: HHJIUUAMYGBVSD-YTFFSALGSA-N InChI=1/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1; Key: HHJIUUAMYGBVSD-YTFFSALGBY ;
Properties
Molecular formula	C27H36F2O5
Molar mass	478.57 g mol−1
Melting point	220 °C (428 °F; 493 K)
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references