ジフルコルトロン
- 関
- diflucortolone valerate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/22 20:11:32」(JST)
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Diflucortolone
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Clinical data |
Synonyms |
Difluocortolone |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
ATC code |
- D07AC06 (WHO)
D07XC04 (WHO) (combinations)
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Identifiers |
CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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KEGG |
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ECHA InfoCard |
100.018.203 |
Chemical and physical data |
Formula |
C22H28F2O4 |
Molar mass |
394.452 g/mol |
3D model (JSmol) |
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SMILES
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C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C)F
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InChI
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InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
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Key:OGPWIDANBSLJPC-RFPWEZLHSA-N
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(verify) |
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Diflucortolone (INN), or difluocortolone, is a corticosteroid.
See also
References
Glucocorticoids and antiglucocorticoids (H02)
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Glucocorticoids |
Natural |
- Cortisone
- Cortodoxone (cortexolone, 11-deoxycortisol)
- Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone)
- Hydrocortisone (cortisol)#
- Prebediolone acetate
- Pregnenolone
- Pregnenolone acetate
- Pregnenolone succinate
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Synthetic |
- Cortisol-like and related (16-unsubstituted): Chloroprednisone
- Cloprednol
- Difluprednate
- Fludrocortisone
- Flugestone acetate (flurogestone acetate)
- Fluocinolone
- Fluorometholone
- Fluperolone
- Fluprednisolone
- Loteprednol
- Medrysone
- Methylprednisolone
- Methylprednisolone esters
- Prednicarbate
- Prednisolone
- Prednisone
- Tixocortol
- Methasones and related (16-substituted): Alclometasone
- Beclometasone
- Betamethasone
- Clobetasol
- Clobetasone
- Clocortolone
- Cortivazol
- Desoximetasone
- Dexamethasone
- Diflorasone
- Diflucortolone
- Fluclorolone
- Flumetasone
- Fluocortin
- Fluocortolone
- Fluprednidene acetate
- Fluticasone
- Fluticasone furoate
- Fluticasone propionate
- Halometasone
- Meprednisone
- Mometasone
- Paramethasone
- Prednylidene
- Rimexolone
- Triamcinolone
- Ulobetasol (halobetasol)
- Cyclic ketals (16,17-cyclized): Amcinonide
- Budesonide
- Ciclesonide
- Deflazacort
- Desonide
- Fluclorolone acetonide (flucloronide)
- Fludroxycortide (flurandrenolone, flurandrenolide)
- Flunisolide
- Fluocinolone acetonide
- Fluocinonide
- Formocortal (fluoroformylone)
- Halcinonide
- Triamcinolone acetonide
- Triamcinolone acetonide esters
|
|
Antiglucocorticoids |
- Antagonists: Aglepristone
- Ketoconazole
- Mifepristone
- Ulipristal acetate
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Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
|
Glucocorticoid receptor modulators
|
GR |
Agonists |
- Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone
- 5α-Dihydrocorticosterone
- 9α-Fluorocortisone (alfluorone)
- 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
- 11-Dehydrocorticosterone acetate
- 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
- 11-Deoxycortisol (cortodoxone, cortexolone)
- Cortifen (cortiphen, kortifen)
- Cortodoxone acetate
- 21-Deoxycortisol
- Δ7-Prednisolone
- Δ7-Prednisolone 21-acetate
- Amebucort
- Chloroprednisone
- Cloprednol
- Corticosterone
- Corticosterone acetate
- Corticosterone benzoate
- Cortisol (hydrocortisone)
- Benzodrocortisone (hydrocortisone benzoate)
- Hydrocortamate (hydrocortisone diethylaminoacetate)
- Hydrocortisone esters
- Cortisone
- Deprodone
- Dichlorisone
- Dichlorisone acetate
- Dichlorisone diacetate
- Difluprednate
- Endrisone (endrysone)
- Etiprednol
- Etiprednol dicloacetate (etiprednol dichloroacetate)
- Fludrocortisone (fludrocortone)
- Fluorometholone
- Fluperolone
- Fluprednisolone
- Halopredone
- Halopredone acetate (halopredone diacetate)
- Isoflupredone (9α-fluoroprednisolone)
- Loteprednol
- Mazipredone (depersolone)
- Medrysone
- Methylprednisolone
- Methylprednisolone esters
- Prebediolone
- Prednisolone
- Prednazate
- Prednazoline
- Prednicarbate (prednisolone ethylcarbonate propionate)
- Prednimustine
- Prednisolamate (prednisolone diethylaminoacetate)
- Prednisolone esters
- Prednisone
- Pregnenolone
- Pregnenolone acetate
- Pregnenolone succinate (pregnenolone hemisuccinate)
- Resocortol
- Tipredane
- Tixocortol
- Butixocort (tixocortol butyrate)
- Tixocortol pivalate
- Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone
- Alclometasone
- Alclometasone dipropionate
- Amelometasone
- Beclometasone (beclomethasone)
- Betamethasone (betametasone)
- Betamethasone esters
- Cortobenzolone (betamethasone salicylate)
- Ciclometasone (ciclomethasone, cyclomethasone)
- Clobetasol
- Clobetasone
- Clocortolone
- Cloticasone
- Cormetasone (cormethasone)
- Descinolone
- Desoximetasone (desoxymethasone)
- Dexamethasone (dexametasone)
- Diflorasone
- Diflucortolone
- Diflucortolone pivalate
- Diflucortolone valerate
- Dimesone
- Doxibetasol (doxybetasol)
- Fluclorolone
- Flumetasone (flumethasone)
- Flumetasone acetate
- Flumetasone pivalate
- Fluocinolone
- Fluocortin
- Fluocortin butyl (fluocortin butylate)
- Fluocortolone
- Fluprednidene (fluprednylidene)
- Fluticasone
- Fluticasone furoate
- Fluticasone propionate
- Halocortolone
- Halometasone
- Icometasone
- Icometasone enbutate (icometasone butyrate acetate)
- Isoprednidene
- Locicortolone (locicortone)
- Locicortolone dicibate (locicortone dicibate)
- Meclorisone
- Meprednisone (methylprednisone)
- Meprednisone acetate
- Meprednisone hydrogen succinate (methylprednisone hemisuccinate)
- Mometasone
- Paramethasone
- Paramethasone acetate
- Paramethasone disodium phosphate
- Paramethasone phosphate
- Prednylidene
- Prednylidene diethylaminoacetate
- Rimexolone
- Ticabesone
- Timobesone
- Triamcinolone
- Ulobetasol (halobetasol)
- Vamorolone
- Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide)
- Amcinafal (triamcinolone pentanonide)
- Amcinafide (triamcinolone acetophenide)
- Amcinonide (triamcinolone acetate cyclopentanonide)
- Budesonide
- Ciclesonide
- Cicortonide
- Deflazacort (azacort)
- Descinolone acetonide
- Desonide (hydroxyprednisolone acetonide)
- Desonide disodium phosphate
- Desonide pivalate
- Dexbudesonide
- Drocinonide
- Fluazacort
- Fluclorolone acetonide (flucloronide)
- Fludroxycortide (flurandrenolone, flurandrenolide)
- Flumoxonide
- Flunisolide
- Fluocinolone acetonide
- Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
- Fluocinonide (fluocinolide, fluocinolone acetonide acetate)
- Procinonide (fluocinolone acetonide propionate)
- Formocortal
- Halcinonide
- Itrocinonide
- Rofleponide
- Tralonide
- Triamcinolone acetonide
- Flupamesone (triamcinolone acetonide metembonate)
- Triamcinolone acetonide esters
- Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)
- Triclonide
- Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol
- Cortivazol
- Domoprednate
- Naflocort
- Nicocortonide
- Nivacortol (nivazol)
- Oxisopred
- RU-28362
- Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate
- 17α-Hydroxyprogesterone
- Chlormadinone acetate
- Cyproterone
- Cyproterone acetate
- Delmadinone acetate
- Flugestone
- Flugestone acetate (flurogestone acetate)
- Fluoxymesterone
- Gestodene
- Medrogestone
- Medroxyprogesterone acetate
- Megestrol acetate
- Metribolone
- Norgestomet
- Osaterone acetate
- Progesterone
- Promegestone
- Quingestrone
- Segesterone acetate (nestorone)
- Tetrahydrogestrinone
- Nonsteroidal glucocorticoids: AZD-5423
- GSK-9027
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Mixed
(SEGRMs) |
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
Antagonists |
- 7α-Hydroxy-DHEA
- 17α-Methylprogesterone
- Aglepristone
- Asoprisnil
- Asoprisnil ecamate
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- ORG-34116
- ORG-34517 (SCH-900636)
- ORG-34850
- Pregnenolone 16α-carbonitrile
- Relacorilant (CORT-125134)
- RTI 3021–012
- RTI 3021–022
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
|
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- See also
- Receptor/signaling modulators
- Glucocorticoids and antiglucocorticoids
- Mineralocorticoid receptor modulators
- List of corticosteroids
|
English Journal
- The association of isoconazole-diflucortolone in the treatment of pediatric tinea corporis.
- Veraldi S1, Schianchi R2, Pontini P1, Gorani A1.
- The Journal of dermatological treatment.J Dermatolog Treat.2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19.
- PMID 28753055
- Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate.
- Abdel-Salam FS1, Mahmoud AA2,3, Ammar HO2,3, Elkheshen SA3,4.
- Journal of liposome research.J Liposome Res.2017 Mar;27(1):41-55. doi: 10.3109/08982104.2016.1149866. Epub 2016 Mar 9.
- PMID 26956098
- Effective topical delivery systems for corticosteroids: dermatological and histological evaluations.
- Eroğlu İ1, Azizoğlu E1, Özyazıcı M1, Nenni M2, Gürer Orhan H2, Özbal S3, Tekmen I3, Ertam İ4, Ünal İ4, Özer Ö1.
- Drug delivery.Drug Deliv.2016 Jun;23(5):1502-13. doi: 10.3109/10717544.2014.960981. Epub 2014 Sep 26.
- PMID 25259424
Japanese Journal
- 膀胱全摘・回腸瘻造設術後に発症した Peristomal Pyoderma Gangrenosum の1例 : 107報告例の検討
- 西日本皮膚科 = The Nishinihon journal of dermatology 70(3), 257-260, 2008-06-01
- NAID 10024943652
- 尋常性乾癬に対するカルシポトリオール軟膏とステロイド外用薬併用治療とステロイド外用単独療法との有効性比較 : カルシポトリオール・吉草酸ジフルコルトロン軟膏外用併用療法と吉草酸ジフルコルトロン軟膏単独外用療法との比較試験
- 西日本皮膚科 = The Nishinihon journal of dermatology 68(1), 76-81, 2006-02-01
- NAID 10018351175
- 尋常性乾癬に対する活性型ビタミンD_3軟膏治療における吉草酸ジフルコルトロン軟膏の併用効果
- 西日本皮膚科 = The Nishinihon journal of dermatology 66(2), 188-191, 2004-04-01
- NAID 10019000514
Related Links
- diflucortolone /di·flu·cor·to·lone/ (di″floo-kor´tah-lōn″) a synthetic corticosteroid used topically as the valerate salt for the relief of inflammation and pruritus in corticosteroid-responsive dermatoses. diflucortolone [diflo o kor′tählōn] a ...
- Diflucortolone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Diflucortolone is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on ...
★リンクテーブル★
[★]
- 英
- diflucortolone
- 化
- 吉草酸ジフルコルトロン, diflucortolone valerate
- 商
- アフゾナ、アルゾナ、テクスメテン、ネイサート、ネリコルト、ネリザ、ネリゾナ、ネリダロン、ネリプロクト、ユートロン
- 関
- 鎮痛,鎮痒,収歛,消炎剤
[★]
ジフルコルトロン, diflucortolone。吉草酸ジフルコルトロン