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1. 小児に対する手術室外での鎮静処置に使用する薬剤 pharmacologic agents for pediatric procedural sedation outside of the operating room
2. 重症患者における鎮静鎮痛剤：特性、投与レジメン、および副作用 sedative analgesic medications in critically ill patients properties dosage regimens and adverse effects
3. 小児に対する手術室外での鎮静処置に使用する薬剤の選択 selection of medications for pediatric procedural sedation outside of the operating room
4. 重症患者における鎮静鎮痛剤：選択、開始、維持、および離脱 sedative analgesic medications in critically ill patients selection initiation maintenance and withdrawal
5. 非心臓手術施行時の肥満患者に対する麻酔 anesthesia for the obese patient undergoing non cardiac surgery

The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension.

Friesen RH, Nichols CS, Twite MD, Cardwell KA, Pan Z, Pietra B, Miyamoto SD, Auerbach SR, Darst JR, Ivy DD.SourceDepartment of Anesthesiology, Children's Hospital Colorado, University of Colorado, 13123 E. 16th Ave., Aurora, CO 80045. robert.friesen@childrenscolorado.or.
Anesthesia and analgesia.Anesth Analg.2013 Oct;117(4):953-9. doi: 10.1213/ANE.0b013e3182a15aa6. Epub 2013 Aug 19.
BACKGROUND: Dexmedetomidine, an α-2 receptor agonist, is widely used in children with cardiac disease. Significant hemodynamic responses, including systemic and pulmonary vasoconstriction, have been reported after dexmedetomidine administration. Our primary goal of this prospective, observational s
PMID 23960035

Pain, agitation, delirium, and neuromuscular blockade: a review of basic pharmacology, assessment, and monitoring.

Altshuler J, Spoelhof B.SourceDepartment of Pharmacy, Memorial Hermann-Texas Medical Center, Houston, Texas.
Critical care nursing quarterly.Crit Care Nurs Q.2013 Oct-Dec;36(4):356-69. doi: 10.1097/CNQ.0b013e3182a10dbf.
Agitation, pain, and delirium are focal points for targeted pharmacologic therapy in the intensive care unit. Understanding how to treat these essential entities necessitates fundamental understanding of the pharmacology of sedation, analgesia, and antipsychotics. Monitoring the effectiveness of the
PMID 24002426

Suppression of phagosome proteolysis and Matrigel migration with the α2-adrenergic receptor agonist dexmedetomidine in murine dendritic cells.

Ueshima H, Inada T, Shingu K.SourceDepartment of Anesthesiology, Kansai Medical University , Osaka , Japan.
Immunopharmacology and immunotoxicology.Immunopharmacol Immunotoxicol.2013 Oct;35(5):558-66. doi: 10.3109/08923973.2013.822509. Epub 2013 Aug 8.
Abstract Dexmedetomidine is a highly-selective α2-adrenergic receptor agonist used for sedation of critically ill patients in an intensive care setting. Dendritic cells (DCs) in peripheral tissues sense certain foreign antigens and ingest and process them, while migrating to the regional lymph node
PMID 23927488

Effects of dexmedetomidine on cerebrovascular circulation and intracranial pressure in anesthetized rabbits

Ando Kayoko,Shibata Hiroki,Momota Yoshihiro
Journal of Osaka Dental University 48(2), 111-116, 2014-10
… Dexmedetomidine hydrochloride (Dex) was administered to rabbits to investigate its effect on mean arterial pressure (MAP), regional cerebral blood flow (r-CBF), and intracranial pressure (ICP). …
NAID 110009865344

SEDATION WITH DEXMEDETOMIDINE HYDROCHLORIDE DURING ENDOSCOPIC SUBMUCOSAL DISSECTION OF GASTRIC CANCER

TAKIMOTO KENGO,UEDA TOMOHIRO,SHIMAMOTO FUKUTARO,KOJIMA YUSUKE,FUJINAGA YOSUKE,KASHIWA ATUFUMI,YAMAUCHI HIROAKI,MATSUYAMA KIICHI,TOYONAGA TAKASHI,YOSHIKAWA TOSHIKAZU
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 23(2), 176-181, 2011-04-01
NAID 10029312945