deoxyadenosine

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WordNet

1. a nucleoside component of DNA; composed of adenosine and deoxyribose

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/30 17:45:41」(JST)

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Deoxyadenosine
Identifiers
CAS number	958-09-8 Y
PubChem	636
ChemSpider	13135 Y
UNII	P582C98ULC Y
MeSH	2'-deoxyadenosine
ChEBI	CHEBI:17256 Y
ChEMBL	CHEMBL416340 N
Jmol-3D images	Image 1
SMILES n2c1c(ncnc1n(c2)[C@@H]3O[C@@H]([C@@H](O)C3)CO)N
InChI InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 Y Key: OLXZPDWKRNYJJZ-RRKCRQDMSA-N Y InChI=1/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 Key: OLXZPDWKRNYJJZ-RRKCRQDMBK
Properties
Molecular formula	C10H13N5O3
Molar mass	251.24192
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Deoxyadenosine is a deoxyribonucleoside. It is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2' position of its ribose sugar moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with deoxythymidine (T) in double-stranded DNA. In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease(ADA-SCID).

See also

• Deoxyribonucleotide
• Cordycepin (3'-deoxyadenosine)
• Severe combined immunodeficiency

References

Anthony J. F., Susan R., Sean B, John Doebley(2011). Introduction to Genetic Analysis, 10th Edition. NY: W . H. Freeman and Company. ISBN 1-4641-0661

UpToDate Contents

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• 1. アデノシンデアミナーゼ欠損症：病因、臨床症状、および診断 adenosine deaminase deficiency pathogenesis clinical manifestations and diagnosis
• 2. アデノシンデアミナーゼ欠損症：治療 adenosine deaminase deficiency treatment
• 3. ハーブ含有アリストロキン酸（AA）誘発性腎症 nephropathy induced by aristolochic acid aa containing herbs
• 4. プリンヌクレオシドホスホリラーゼ欠損症 purine nucleoside phosphorylase deficiency
• 5. 卵細胞質内精子注入法 intracytoplasmic sperm injection

English Journal

• 3'-Deoxyadenosine (CordyCepin) Produces A Rapid And Robust Antidepressant Effect Via Enhancing Prefrontal Ampa Receptor Signaling Pathway.

• Li B1, Hou Y1, Zhu M1, Bao H1, Nie J1, Zhang GY2, Shan L2, Yao Y2, Du K3, Yang H1, Li M4, Zheng B1, Xu X5, Xiao C1, Du J6.
• The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2015 Oct 6. pii: pyv112. doi: 10.1093/ijnp/pyv112. [Epub ahead of print]
• BACKGROUND: The development of rapid and safe antidepressant for the treatment of major depression is in urgent demand. Converging evidence suggests that glutamatergic signaling seems to play important roles in the pathophysiology of depression.METHODS: We studied the antidepressant effect of 3'-deo
• PMID 26443809

• 4'-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus.

• Takamatsu Y1, Tanaka Y2, Kohgo S3,4, Murakami S2, Singh K5, Das D1, Venzon DJ6, Amano M7, Higashi-Kuwata N3,7, Aoki M1,7,8, Delino NS1, Hayashi S2, Takahashi S9, Sukenaga Y3, Haraguchi K4, Sarafianos SG5, Maeda K1,3, Mitsuya H1,3,7.
• Hepatology (Baltimore, Md.).Hepatology.2015 Oct;62(4):1024-36. doi: 10.1002/hep.27962. Epub 2015 Aug 25.
• Certain nucleoside/nucleotide reverse transcriptase (RT) inhibitors (NRTIs) are effective against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). However, both viruses often acquire NRTI resistance, making it crucial to develop more-potent agents that offer profound viral su
• PMID 26122273

• Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii.

• Giroux X1, MacNeill SA2.
• FEMS microbiology letters.FEMS Microbiol Lett.2015 Sep 28. pii: fnv181. [Epub ahead of print]
• DNA ligases play an essential role in many aspects of DNA metabolism in all three domains of life. The haloarchaeal organism Haloferax volcanii encodes both ATP- and NAD+-dependent DNA ligase enzymes designated LigA and LigN, respectively. Neither LigA nor LigN alone is required for cell viability b
• PMID 26420852

Japanese Journal

• Formation of 8-S-[L]-Cysteinyladenosine from 8-Bromoadenosine and Cysteine

• Chemical and pharmaceutical bulletin 66(2), 184-187, 2018-02
• NAID 40021446593

• Formation of 8-<i>S</i>-L-Cysteinyladenosine from 8-Bromoadenosine and Cysteine

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 66(2), 184-187, 2018
• NAID 130006328066

• プロダクトイノベーション 夢のエイズ薬? EFdA (4'-C-Ethynyl-2-fluoro-2'-deoxyadenosine)の創製 : 新しい概念による抗ウイルスヌクレオシド薬の創製研究

• 化学と生物 : 日本農芸化学会会誌 : 生命・食・環境 55(12), 833-840, 2017-12
• NAID 40021410942

Related Links

• 2'-Deoxyadenosine 16373-93-6 | 東京化成工業株式会社

[2'-Deoxyadenosine] [16373-93-6] | 価格や在庫、物性値などの詳細情報ページです。 ... ・川口の在庫は即日，つくばの在庫は2〜3日以内の出荷となります。・詳細につきましては，お手数ですが営業部までお問い合わせください。

• Deoxyadenosine | Define Deoxyadenosine at Dictionary.com

deoxyadenosine de·ox·y·a·den·o·sine (dē-ŏk'sē-ə-děn'ə-sēn') n. One of the four principal nucleosides of DNA, composed of adenine and deoxyribose.

Related Pictures

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★リンクテーブル★

リンク元	「dA」「デオキシアデノシン」
拡張検索	「deoxyadenosine monophosphate」「dideoxyadenosine」「chlorodeoxyadenosine」

「dA」

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• デオキシアデノシン

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deoxyadenosine

「デオキシアデノシン」

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英

deoxyadenosine、dA

「deoxyadenosine monophosphate」

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デオキシアデノシン一リン酸、デオキシアデニル酸

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dAMP

「dideoxyadenosine」

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ジデオキシアデノシン

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ddA

「chlorodeoxyadenosine」

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クロロデオキシアデノシン