クロロデオキシアデノシン
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English Journal
- Cytotoxicity of chemotherapeutic agents in glyceraldehyde-3-phosphate dehydrogenase-depleted human lung carcinoma A549 cells with the accelerated senescence phenotype.
- Phadke M, Krynetskaia N, Krynetskiy E.SourceDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA.
- Anti-cancer drugs.Anticancer Drugs.2013 Apr;24(4):366-74. doi: 10.1097/CAD.0b013e32835e3378.
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a central role in glycolysis. Because cancer cells rely on aerobic glycolysis rather than oxidative phosphorylation, GAPDH-depleting agents have a therapeutic potential to impede cancer cell proliferation. Knockdown of GAPDH by RNA interference
- PMID 23377192
- The role of clofarabine in acute myeloid leukemia.
- Ghanem H, Kantarjian H, Ohanian M, Jabbour E.SourceDepartment of Leukemia , The University of Texas M. D. Anderson Cancer Center, Houston, TX , USA.
- Leukemia & lymphoma.Leuk Lymphoma.2013 Apr;54(4):688-98. doi: 10.3109/10428194.2012.726722. Epub 2012 Sep 28.
- Abstract Clofarabine is a second-generation purine nucleoside analog that has been synthesized to overcome the limitations and incorporate the best qualities of fludarabine and cladribine. Clofarabine acts by inhibiting ribonucleotide reductase and DNA polymerase, thereby depleting the amount of int
- PMID 22957815
- Mechanisms of action of the anti-VEGF monoclonal antibody bevacizumab on chronic lymphocytic leukemia cells.
- Bogusz J, Majchrzak A, Mędra A, Cebula-Obrzut B, Robak T, Smolewski P.SourceDepartment of Experimental Hematology, Department of Hematology, Medical University of Lodz, Poland.
- Postȩpy higieny i medycyny doświadczalnej (Online).Postepy Hig Med Dosw (Online).2013 Mar 1;67(0):107-18.
- Introduction: Chronic lymphocytic leukemia (CLL) remains incurable; therefore searching for new therapeutic strategies in this disease is necessary. An important mechanism of tumor development is neoangiogenesis. A potent antiangiogenic factor, bevacizumab (Avastin, AVA), has been poorly explored in
- PMID 23475487
Japanese Journal
- Spontaneous remission of 2-chlorodeoxyadenosine (2-CdA)-related secondary myelodysplastic syndrome in a patient with refractory Langerhans cell histiocytosis
- Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine : a nationwide survey in Japan
- 単クローン性IgMの増加を伴ったMALTリンパ腫の一症例
Related Links
- Chlorodeoxyadenosine - Medical Terms is a service who provides descriptions and explanations of health related terms ... Broader Terms antineoplastic, deoxyadenosine, immunosuppressive Facts (generated by robot; please edit if ...
- 2-CdA is mostly used to treat hairy cell leukemia, chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphomas ... Generic name: Cladribine Trade names: Leustatin TM Other names: 2-CdA, 2-Chlorodeoxyadenosine Chemocare ...